General Information of the Compound
Compound ID
CP0436580
Compound Name
1-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)cyclopentane-1-carboxamide
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Structure
Formula
C28H36N2O
Molecular Weight
416.609
Canonical SMILES
O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1(CCCC1)c1ccccc1
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InChI
InChI=1S/C28H36N2O/c31-26(28(14-6-7-15-28)24-10-2-1-3-11-24)29-19-8-20-30-21-17-27(18-22-30)16-13-23-9-4-5-12-25(23)27/h1-5,9-12H,6-8,13-22H2,(H,29,31)
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InChIKey
OQTRBKFDOSHNIO-UHFFFAOYSA-N
Physicochemical Property
logP
4.9847
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
32.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11661648
SID: 16765325
ChEMBL ID
CHEMBL201964
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS