General Information of the Compound
Compound ID
CP0874932
Compound Name
exo-6-[8-[Bis(2-chlorophenyl)-methyl]-8-azabicyclo[3.2.1]oct-3-yl]-3-pyridinol
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Formula
C25H24Cl2N2O
Molecular Weight
439.386
Canonical SMILES
Oc1ccc([C@H]2C[C@H]3CC[C@@H](C2)N3C(c2ccccc2Cl)c2ccccc2Cl)nc1
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InChI
InChI=1S/C25H24Cl2N2O/c26-22-7-3-1-5-20(22)25(21-6-2-4-8-23(21)27)29-17-9-10-18(29)14-16(13-17)24-12-11-19(30)15-28-24/h1-8,11-12,15-18,25,30H,9-10,13-14H2/t16-,17+,18-
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InChIKey
ROMUGJLHDLJNCR-BCDXTJNWSA-N
Physicochemical Property
logP
6.594
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
36.36
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 85282549
ChEMBL ID
CHEMBL3084655
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 234 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 24 nM
   TI
   LI
   LO
   TS