General Information of the Compound
Compound ID
CP0731080
Compound Name
(+/-)-1-(4-(2-(tert-butylthio)-5-chloro-1H-benzo[d]imidazol-6-yl)-3-methylpiperazin-1-yl)propan-2-one
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Structure
Formula
C19H27ClN4OS
Molecular Weight
394.972
Canonical SMILES
CC(=O)CN1CCN(c2cc3[nH]c(SC(C)(C)C)nc3cc2Cl)C(C)C1
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InChI
InChI=1S/C19H27ClN4OS/c1-12-10-23(11-13(2)25)6-7-24(12)17-9-16-15(8-14(17)20)21-18(22-16)26-19(3,4)5/h8-9,12H,6-7,10-11H2,1-5H3,(H,21,22)
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InChIKey
MIXYMKFBPWKETL-UHFFFAOYSA-N
Physicochemical Property
logP
4.2064
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
52.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574003
ChEMBL ID
CHEMBL466631
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 38 nM
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS