General Information of the Compound
Compound ID
CP0375817
Compound Name
2-benzyl-N,N-dimethyl-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
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Structure
Formula
C23H30N2O2S
Molecular Weight
398.572
Canonical SMILES
CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1
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InChI
InChI=1S/C23H30N2O2S/c1-24(2)22(26)20(16-18-6-4-3-5-7-18)17-25-12-10-23(11-13-25)21-19(8-14-27-23)9-15-28-21/h3-7,9,15,20H,8,10-14,16-17H2,1-2H3
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InChIKey
UUPXLXYQUQZBHW-UHFFFAOYSA-N
Physicochemical Property
logP
3.559
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
32.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 60154190
SID: 144085115
ChEMBL ID
CHEMBL2088040
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 9.4 nM
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   LI
   LO
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