General Information of the Compound
Compound ID
CP0391686
Compound Name
3-ethyl-1-[1-(1H-indol-4-ylmethyl)piperidin-4-yl]-3H-indol-2-one
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Structure
Formula
C24H27N3O
Molecular Weight
373.5
Canonical SMILES
CCC1C(=O)N(C2CCN(Cc3cccc4[nH]ccc34)CC2)c2ccccc12
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InChI
InChI=1S/C24H27N3O/c1-2-19-21-7-3-4-9-23(21)27(24(19)28)18-11-14-26(15-12-18)16-17-6-5-8-22-20(17)10-13-25-22/h3-10,13,18-19,25H,2,11-12,14-16H2,1H3
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InChIKey
IHHKRBWQSBPVHH-UHFFFAOYSA-N
Physicochemical Property
logP
4.6727
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
39.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90655975
ChEMBL ID
CHEMBL3262548
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 12.82 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 23.4 nM
   TI
   LI
   LO
   TS
2
Ki = 10.6 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
2
Ki = 11.1 nM
   TI
   LI
   LO
   TS