General Information of the Compound
Compound ID
CP0485583
Compound Name
CHEMBL4465668
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Formula
C24H39Cl2N3
Molecular Weight
440.503
Canonical SMILES
Cl.Cl.CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CCN)c2ccccc12
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InChI
InChI=1S/C24H37N3.2ClH/c1-18(2)19-7-9-21(10-8-19)26-15-12-22(13-16-26)27-17-20(11-14-25)23-5-3-4-6-24(23)27;;/h3-6,17-19,21-22H,7-16,25H2,1-2H3;2*1H/t19-,21+;;
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InChIKey
DGBPMRFUIBNOCA-XWOHEVPJSA-N
Physicochemical Property
logP
5.8378
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
34.19
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4465668
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2750 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 437 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 139 nM
   TI
   LI
   LO
   TS
2
Ki = 2.27 nM
   TI
   LI
   LO
   TS