General Information of the Compound
Compound ID
CP0392311
Compound Name
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
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Structure
Formula
C25H32ClN3O3
Molecular Weight
458.002
Canonical SMILES
CC(C)C(Oc1cc(C)ccc1Cl)C(O)CN1CCC(CC1)n1c2ccccc2[nH]c1=O
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InChI
InChI=1S/C25H32ClN3O3/c1-16(2)24(32-23-14-17(3)8-9-19(23)26)22(30)15-28-12-10-18(11-13-28)29-21-7-5-4-6-20(21)27-25(29)31/h4-9,14,16,18,22,24,30H,10-13,15H2,1-3H3,(H,27,31)
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InChIKey
BOWNRQWYUOTCCD-UHFFFAOYSA-N
Physicochemical Property
logP
4.39282
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
70.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44391156
ChEMBL ID
CHEMBL182144
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 88 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 108 nM
   TI
   LI
   LO
   TS