General Information of the Compound
Compound ID
CP0777561
Compound Name
exo-8-[Bis(2-chlorophenyl)methyl]-3-(5-oxazolyl)-8-azabicyclo-[3.2.1]octane
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Formula
C23H22Cl2N2O
Molecular Weight
413.348
Canonical SMILES
Clc1ccccc1C(c1ccccc1Cl)N1[C@@H]2CC[C@H]1C[C@@H](c1cnco1)C2
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InChI
InChI=1S/C23H22Cl2N2O/c24-20-7-3-1-5-18(20)23(19-6-2-4-8-21(19)25)27-16-9-10-17(27)12-15(11-16)22-13-26-14-28-22/h1-8,13-17,23H,9-12H2/t15-,16+,17-
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InChIKey
JOBGGLJPDFQHDJ-BJWYYQGGSA-N
Physicochemical Property
logP
6.4814
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
29.27
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 85282544
ChEMBL ID
CHEMBL3084657
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 272 nM
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   LI
   LO
   TS