General Information of the Compound
Compound ID
CP0869822
Compound Name
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(6-fluoropyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
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Formula
C28H28Cl2FN3O
Molecular Weight
512.456
Canonical SMILES
CC(=O)NC[C@@]1(c2cccc(F)n2)C[C@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
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InChI
InChI=1S/C28H28Cl2FN3O/c1-18(35)32-17-28(25-11-6-12-26(31)33-25)15-19-13-14-20(16-28)34(19)27(21-7-2-4-9-23(21)29)22-8-3-5-10-24(22)30/h2-12,19-20,27H,13-17H2,1H3,(H,32,35)/t19-,20+,28-
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InChIKey
ZERPWCGFRBPSIK-JXHXNGGNSA-N
Physicochemical Property
logP
6.3178
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
45.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3349256
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1284 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 24 nM
   TI
   LI
   LO
   TS