General Information of the Compound
Compound ID
CP0433736
Compound Name
1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one
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Structure
Formula
C32H42N4O4
Molecular Weight
546.712
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3c(C)noc3C)c2=O)C(C)C)c1
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InChI
InChI=1S/C32H42N4O4/c1-21(2)30(39-31-19-26(38-6)12-11-22(31)3)15-18-34-16-13-25(14-17-34)36-29-10-8-7-9-28(29)35(32(36)37)20-27-23(4)33-40-24(27)5/h7-12,19,21,25,30H,13-18,20H2,1-6H3
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InChIKey
DNWBVIHRXCWTCQ-UHFFFAOYSA-N
Physicochemical Property
logP
5.90376
Rotatable Bonds
10
Heavy Atom Count
40
Polar Areas
74.66
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44451517
ChEMBL ID
CHEMBL259120
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 56.23 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.548 nM
   TI
   LI
   LO
   TS