General Information of the Compound
Compound ID
CP0449598
Compound Name
tert-butyl N-[1-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylcarbamoyl)cyclohexyl]carbamate
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Structure
Formula
C28H43N3O3
Molecular Weight
469.67
Canonical SMILES
CC(C)(C)OC(=O)NC1(CCCCC1)C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
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InChI
InChI=1S/C28H43N3O3/c1-26(2,3)34-25(33)30-28(13-7-4-8-14-28)24(32)29-18-9-19-31-20-16-27(17-21-31)15-12-22-10-5-6-11-23(22)27/h5-6,10-11H,4,7-9,12-21H2,1-3H3,(H,29,32)(H,30,33)
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InChIKey
HQTWMYBMGBATLF-UHFFFAOYSA-N
Physicochemical Property
logP
4.7003
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
70.67
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44407145
ChEMBL ID
CHEMBL381508
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS