General Information of the Compound
Compound ID
CP0816827
Compound Name
(+/-)-methyl 3-(5-chloro-6-(4-ethylpiperazin-1-yl)-1H-benzo[d]imidazol-2-ylthio)-3-methylcyclopentylcarbamate
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Structure
Formula
C21H30ClN5O2S
Molecular Weight
452.024
Canonical SMILES
CCN1CCN(c2cc3[nH]c(SC4(C)CCC(NC(=O)OC)C4)nc3cc2Cl)CC1
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InChI
InChI=1S/C21H30ClN5O2S/c1-4-26-7-9-27(10-8-26)18-12-17-16(11-15(18)22)24-19(25-17)30-21(2)6-5-14(13-21)23-20(28)29-3/h11-12,14H,4-10,13H2,1-3H3,(H,23,28)(H,24,25)
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InChIKey
CDOAKUQOANRBJU-UHFFFAOYSA-N
Physicochemical Property
logP
4.1175
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
73.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574053
ChEMBL ID
CHEMBL467473
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 16 nM
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS