General Information of the Compound
Compound ID
CP0371610
Compound Name
2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-N,N-dimethyl-acetamide
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Structure
Formula
C30H42N4O4
Molecular Weight
522.69
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CC(=O)N(C)C)c2=O)C(C)C)c1
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InChI
InChI=1S/C30H42N4O4/c1-21(2)27(38-28-19-24(37-6)12-11-22(28)3)15-18-32-16-13-23(14-17-32)34-26-10-8-7-9-25(26)33(30(34)36)20-29(35)31(4)5/h7-12,19,21,23,27H,13-18,20H2,1-6H3
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InChIKey
JJPNRJDIOHTAQZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.33882
Rotatable Bonds
10
Heavy Atom Count
38
Polar Areas
68.94
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437613
ChEMBL ID
CHEMBL392548
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 188 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 358 nM
   TI
   LI
   LO
   TS
2
Ki = 22 nM
   TI
   LI
   LO
   TS