General Information of the Compound
Compound ID
CP0449596
Compound Name
benzyl (4R)-4-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylcarbamoyl)-1,3-oxazolidine-3-carboxylate
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Structure
Formula
C28H35N3O4
Molecular Weight
477.605
Canonical SMILES
O=C(NCCCN1CCC2(CCc3ccccc23)CC1)[C@H]1COCN1C(=O)OCc1ccccc1
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InChI
InChI=1S/C28H35N3O4/c32-26(25-20-34-21-31(25)27(33)35-19-22-7-2-1-3-8-22)29-15-6-16-30-17-13-28(14-18-30)12-11-23-9-4-5-10-24(23)28/h1-5,7-10,25H,6,11-21H2,(H,29,32)/t25-/m1/s1
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InChIKey
QUXMHGWVQZPUGP-RUZDIDTESA-N
Physicochemical Property
logP
3.4678
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
71.11
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44407084
ChEMBL ID
CHEMBL380786
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 131 nM
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