General Information of the Compound
Compound ID
CP0449603
Compound Name
(2Z)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-3-(2-methoxyphenyl)prop-2-enamide
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Structure
Formula
C26H32N2O2
Molecular Weight
404.554
Canonical SMILES
COc1ccccc1\C=C/C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
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InChI
InChI=1S/C26H32N2O2/c1-30-24-10-5-3-8-22(24)11-12-25(29)27-17-6-18-28-19-15-26(16-20-28)14-13-21-7-2-4-9-23(21)26/h2-5,7-12H,6,13-20H2,1H3,(H,27,29)/b12-11-
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InChIKey
XWZAXTMSNMGCNP-QXMHVHEDSA-N
Physicochemical Property
logP
4.1947
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
41.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44406970
ChEMBL ID
CHEMBL437128
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS