General Information of the Compound
Compound ID
CP0859623
Compound Name
(rel)-(3-benzyl-8-(bis(2-chlorophenyl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)methanamine
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Formula
C28H30Cl2N2
Molecular Weight
465.468
Canonical SMILES
NC[C@@]1(Cc2ccccc2)C[C@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
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InChI
InChI=1S/C28H30Cl2N2/c29-25-12-6-4-10-23(25)27(24-11-5-7-13-26(24)30)32-21-14-15-22(32)18-28(17-21,19-31)16-20-8-2-1-3-9-20/h1-13,21-22,27H,14-19,31H2/t21-,22+,28+
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InChIKey
QRAJWIFPCXGNCX-BWSICMMHSA-N
Physicochemical Property
logP
6.8974
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
29.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3349286
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1336 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 11 nM
   TI
   LI
   LO
   TS