General Information of the Compound
Compound ID
CP0432390
Compound Name
8-(bis(2-chlorophenyl)methyl)-3-phenyl-3-(1H-1,2,4-triazol-3-yl)-8-azabicyclo[3.2.1]octane
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Structure
Formula
C28H26Cl2N4
Molecular Weight
489.45
Canonical SMILES
Clc1ccccc1C(N1C2CCC1CC(C2)(c1nnc[nH]1)c1ccccc1)c1ccccc1Cl
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InChI
InChI=1S/C28H26Cl2N4/c29-24-12-6-4-10-22(24)26(23-11-5-7-13-25(23)30)34-20-14-15-21(34)17-28(16-20,27-31-18-32-33-27)19-8-2-1-3-9-19/h1-13,18,20-21,26H,14-17H2,(H,31,32,33)
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InChIKey
QZRGMVAIBSBSTK-UHFFFAOYSA-N
Physicochemical Property
logP
6.814
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
44.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574790
ChEMBL ID
CHEMBL513660
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5.3 nM
   TI
   LI
   LO
   TS