General Information of the Compound
Compound ID
CP0127782
Compound Name
2-[exo-8-[Bis(2-chlorophenyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl]-1-piperidineacetonitrile
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Structure
Formula
C27H31Cl2N3
Molecular Weight
468.472
Canonical SMILES
Clc1ccccc1C(N1[C@H]2CC[C@H]1CC(C2)C1CCCCN1CC#N)c1ccccc1Cl
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InChI
InChI=1S/C27H31Cl2N3/c28-24-9-3-1-7-22(24)27(23-8-2-4-10-25(23)29)32-20-12-13-21(32)18-19(17-20)26-11-5-6-15-31(26)16-14-30/h1-4,7-10,19-21,26-27H,5-6,11-13,15-18H2/t20-,21-,26?/m0/s1
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InChIKey
OGIJRHBALHRLTO-IPEYFGQDSA-N
Physicochemical Property
logP
6.70388
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
30.27
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45268153
ChEMBL ID
CHEMBL561115
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 309 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
Ki = 3 nM
   TI
   LI
   LO
   TS