General Information of the Compound
Compound ID
CP0922733
Compound Name
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(5-(piperidin-1-yl)pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
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Formula
C33H38Cl2N4O
Molecular Weight
577.6
Canonical SMILES
CC(=O)NC[C@@]1(c2ccc(N3CCCCC3)cn2)C[C@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
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InChI
InChI=1S/C33H38Cl2N4O/c1-23(40)37-22-33(31-16-15-26(21-36-31)38-17-7-2-8-18-38)19-24-13-14-25(20-33)39(24)32(27-9-3-5-11-29(27)34)28-10-4-6-12-30(28)35/h3-6,9-12,15-16,21,24-25,32H,2,7-8,13-14,17-20,22H2,1H3,(H,37,40)/t24-,25+,33-
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InChIKey
DNTGCBURADJXRN-NJDHVWSQSA-N
Physicochemical Property
logP
7.169
Rotatable Bonds
7
Heavy Atom Count
40
Polar Areas
48.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3349271
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 99 nM
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