General Information of the Compound
Compound ID
CP0491352
Compound Name
8-[(2,6-dichlorophenyl)methyl]-1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
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Structure
Formula
C26H32Cl2N4O
Molecular Weight
487.475
Canonical SMILES
Clc1cccc(Cl)c1CN1CCC2(CC1)N(CN(CCN1CCCC1)C2=O)c1ccccc1
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InChI
InChI=1S/C26H32Cl2N4O/c27-23-9-6-10-24(28)22(23)19-30-15-11-26(12-16-30)25(33)31(18-17-29-13-4-5-14-29)20-32(26)21-7-2-1-3-8-21/h1-3,6-10H,4-5,11-20H2
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InChIKey
PAUCBEYUHQSRSV-UHFFFAOYSA-N
Physicochemical Property
logP
4.7301
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
30.03
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10323169
SID: 15332660
ChEMBL ID
CHEMBL473904
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 538 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 15 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 37 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2.3 nM
   TI
   LI
   LO
   TS