General Information of the Compound
Compound ID
CP0445059
Compound Name
8-[(4-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
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Structure
Formula
C26H26ClN3O
Molecular Weight
431.967
Canonical SMILES
Clc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
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InChI
InChI=1S/C26H26ClN3O/c27-22-13-11-21(12-14-22)24(20-7-3-1-4-8-20)29-17-15-26(16-18-29)25(31)28-19-30(26)23-9-5-2-6-10-23/h1-14,24H,15-19H2,(H,28,31)
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InChIKey
JOQDUMOMWHMJQQ-UHFFFAOYSA-N
Physicochemical Property
logP
4.8579
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44438967
ChEMBL ID
CHEMBL241080
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 24805 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3529 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5081 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 140 nM
   TI
   LI
   LO
   TS