General Information of the Compound
Compound ID
CP0392310
Compound Name
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-butyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
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Structure
Formula
C23H28ClN3O3
Molecular Weight
429.948
Canonical SMILES
CC(Oc1cc(C)ccc1Cl)C(O)CN1CCC(CC1)n1c2ccccc2[nH]c1=O
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InChI
InChI=1S/C23H28ClN3O3/c1-15-7-8-18(24)22(13-15)30-16(2)21(28)14-26-11-9-17(10-12-26)27-20-6-4-3-5-19(20)25-23(27)29/h3-8,13,16-17,21,28H,9-12,14H2,1-2H3,(H,25,29)
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InChIKey
TXNHLEQUNFKGIN-UHFFFAOYSA-N
Physicochemical Property
logP
3.75672
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
70.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44391099
ChEMBL ID
CHEMBL183603
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 118 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 838 nM
   TI
   LI
   LO
   TS