General Information of the Compound
Compound ID
CP0399272
Compound Name
8-(bis(2-chlorophenyl)methyl)-3-(fluoromethyl)-3-phenyl-8-azabicyclo[3.2.1]octane
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Structure
Formula
C27H26Cl2FN
Molecular Weight
454.416
Canonical SMILES
FCC1(CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
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InChI
InChI=1S/C27H26Cl2FN/c28-24-12-6-4-10-22(24)26(23-11-5-7-13-25(23)29)31-20-14-15-21(31)17-27(16-20,18-30)19-8-2-1-3-9-19/h1-13,20-21,26H,14-18H2
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InChIKey
AEHBDXWWYVXDOD-UHFFFAOYSA-N
Physicochemical Property
logP
7.6171
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
3.24
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574706
ChEMBL ID
CHEMBL506803
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3151 nM
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