General Information of the Compound
Compound ID
CP0423871
Compound Name
2-[(2,6-difluorophenyl)methyl]-N,N-dimethyl-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
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Structure
Formula
C23H28F2N2O2S
Molecular Weight
434.552
Canonical SMILES
CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1c(F)cccc1F
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InChI
InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)17(14-18-19(24)4-3-5-20(18)25)15-27-10-8-23(9-11-27)21-16(6-12-29-23)7-13-30-21/h3-5,7,13,17H,6,8-12,14-15H2,1-2H3
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InChIKey
LGAFQVJAALNXTN-UHFFFAOYSA-N
Physicochemical Property
logP
3.8372
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
32.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 60154193
SID: 144085118
ChEMBL ID
CHEMBL2088044
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 400 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 400 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 400 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10 nM
   TI
   LI
   LO
   TS