| Compound ID |
Compound Name |
Compound Formula |
|
CP0417737
|
8-(2-Thioxo-7(3-allyl)-2-(2-furyl)thiazole[4,3-e]1,2,4-triazolo[1, 5-c]pyrimidine
Show/Hide
|
C13H9N5OS2
|
2
|
| 1 |
Activity = 0.081 nM
|
|
|
| 2 |
Ki = 0.016 nM
|
|
|
|
CP0504228
|
8-(2-Thioxo-7(3-propyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C13H11N5OS2
|
2
|
| 1 |
Activity = 0.1 nM
|
|
|
| 2 |
Ki = 0.38 nM
|
|
|
|
CP0522050
|
8-(2-Thioxo-7(3-butyl)-2-(2-furyl),thiazolo,[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C14H13N5OS2
|
2
|
| 1 |
Activity = 0.11 nM
|
|
|
| 2 |
Ki = 0.12 nM
|
|
|
|
CP0054097
|
2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C18H15N7O
|
6
|
| 1 |
Activity = 0.25 nM
|
|
|
| 2 |
Activity = 0.55 nM
|
|
|
| 3 |
IC50 = 40 nM
|
|
|
| 4 |
Ki = 1.1 nM
|
|
|
| 5 |
Ki = 1.23 nM
|
|
|
| 6 |
Ki = 4.3 nM
|
|
|
|
CP0475062
|
4-[(E)-(4-bromophenyl)methylideneamino]-3-phenyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C17H10BrN3S2
|
2
|
| 1 |
Activity = 0.56 nM
|
|
|
| 2 |
Activity = 0.65 nM
|
|
|
|
CP0039348
|
(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C12H16N6O4
|
7
|
| 1 |
Activity = 0.75 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
| 3 |
Ki = 2.2 nM
|
|
|
| 4 |
Ki = 20 nM
|
|
|
| 5 |
Ki = 35 nM
|
|
|
| 6 |
Ki = 60 nM
|
|
|
| 7 |
Ki = 124 nM
|
|
|
|
CP0381655
|
2-Amino-4-(3-trifluoromethoxy-phenyl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C17H10F3N3O2
|
1
|
| 1 |
Activity = 260 nM
|
|
|
|
CP0444815
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[3,4-bis(phenylmethoxy)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C31H31N7O6
|
2
|
| 1 |
EC50 = 0.64 nM
|
|
|
| 2 |
Ki = 1.8 nM
|
|
|
|
CP0435782
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(2-butyl-5-chloro-1H-imidazol-4-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C18H24ClN9O4
|
2
|
| 1 |
EC50 = 1.1 nM
|
|
|
| 2 |
Ki = 18 nM
|
|
|
|
CP0518339
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[2-methyl-3-(4-propan-2-ylphenyl)propylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C23H31N7O4
|
2
|
| 1 |
EC50 = 1.38 nM
|
|
|
| 2 |
Ki = 6.3 nM
|
|
|
|
CP0469503
|
N-[4-[6-amino-5-cyano-2-[[6-[3-[4-[2-(diethylamino)ethyl]piperazin-1-yl]-3-oxopropyl]pyridin-2-yl]methylsulfanyl]pyrimidin-4-yl]phenyl]acetamide
Show/Hide
|
C32H41N9O2S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
|
CP0455803
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-[(4-fluorophenyl)methoxy]phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C24H24FN7O5
|
2
|
| 1 |
EC50 = 4.05 nM
|
|
|
| 2 |
Ki = 5.5 nM
|
|
|
|
CP0523174
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(cyclopentylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C16H23N7O4
|
2
|
| 1 |
EC50 = 4.34 nM
|
|
|
| 2 |
Ki = 4.1 nM
|
|
|
|
CP0533208
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(2-chloropyridin-3-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C16H17ClN8O4
|
2
|
| 1 |
EC50 = 4.6 nM
|
|
|
| 2 |
Ki = 8.7 nM
|
|
|
|
CP0520198
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(quinolin-6-ylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H20N8O4
|
2
|
| 1 |
EC50 = 5.52 nM
|
|
|
| 2 |
Ki = 6.5 nM
|
|
|
|
CP0455802
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-phenylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C23H23N7O4
|
2
|
| 1 |
EC50 = 5.7 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0489545
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(1H-pyrrol-2-ylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C15H18N8O4
|
2
|
| 1 |
EC50 = 8.52 nM
|
|
|
| 2 |
Ki = 8.3 nM
|
|
|
|
CP0518452
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(2E,4E)-deca-2,4-dienylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H29N7O4
|
2
|
| 1 |
EC50 = 10.15 nM
|
|
|
| 2 |
Ki = 17.5 nM
|
|
|
|
CP0489544
|
4-[(E)-[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]hydrazinylidene]methyl]benzonitrile
Show/Hide
|
C18H18N8O4
|
2
|
| 1 |
EC50 = 15.28 nM
|
|
|
| 2 |
Ki = 8.5 nM
|
|
|
|
CP0455804
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H24N8O4
|
2
|
| 1 |
EC50 = 17.86 nM
|
|
|
| 2 |
Ki = 6.4 nM
|
|
|
|
CP0964764
|
4-(2-(7-amino-2-(4,5-dihydrofuran-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol
Show/Hide
|
C16H17N7O2
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0571545
|
2-amino-8-[2-[4-(2-fluoro-4-methoxyphenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C24H26FN7O3
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0577558
|
2-amino-8-[2-[4-(3-fluoro-5-methoxypyridin-2-yl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H25FN8O3
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0519052
|
US8796284, 1
Show/Hide
|
C10H8BrN7
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0572048
|
5-[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C15H12N6O2
|
1
|
| 1 |
IC50 = 5.72 nM
|
|
|
|
CP0571542
|
2-amino-8-[2-[(2S)-4-(2-fluoro-4-methoxyphenyl)-2-methylpiperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H28FN7O3
|
3
|
| 1 |
IC50 = 6.6 nM
|
|
|
| 2 |
IC50 = 8.3 nM
|
|
|
| 3 |
IC50 = 179.6 nM
|
|
|
|
CP0578576
|
2-amino-8-[2-[(2S)-4-(4-methoxyphenyl)-2-methylpiperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H29N7O3
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0573884
|
2-amino-8-[2-[4-[2-fluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C26H30FN7O4
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0528052
|
2-amino-8-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H23F2N7O2
|
1
|
| 1 |
IC50 = 8.5 nM
|
|
|
|
CP0571546
|
2-amino-8-[2-[4-[2,3-difluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C26H29F2N7O4
|
1
|
| 1 |
IC50 = 9.3 nM
|
|
|
|
CP0962180
|
1-amino-N-(pyridin-2-ylmethyl)benzo[4,5]imidazo[1,2-a]pyrazine-3-carboxamide dihydrchloride
Show/Hide
|
C17H16Cl2N6O
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0579701
|
2-amino-8-[2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H24FN7O2
|
1
|
| 1 |
IC50 = 11.7 nM
|
|
|
|
CP0170975
|
5-Butyl-8-(2-chloro-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C16H15ClN6
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0575044
|
2-amino-8-[2-[4-[4-(difluoromethoxy)-2-fluorophenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C24H24F3N7O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0528051
|
2-amino-8-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C24H27N7O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0171066
|
5,8-Diphenyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C18H12N6
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0534013
|
2-amino-8-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C26H31N7O4
|
1
|
| 1 |
IC50 = 23.8 nM
|
|
|
|
CP0576802
|
2-amino-8-[2-[4-(6-methoxypyridin-3-yl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H26N8O3
|
1
|
| 1 |
IC50 = 29.5 nM
|
|
|
|
CP0538800
|
2-amino-8-[2-[(3R)-4-(4-methoxyphenyl)-3-methylpiperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H29N7O3
|
1
|
| 1 |
IC50 = 37.5 nM
|
|
|
|
CP0573104
|
2-amino-8-[2-[4-(3-methoxyphenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C24H27N7O3
|
1
|
| 1 |
IC50 = 45.5 nM
|
|
|
|
CP0646059
|
5-Butyl-8-methyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C11H14N6
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0720062
|
8-Benzyl-5-butyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H18N6
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0286394
|
N-[2-[(5,6-dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl]acetamide
Show/Hide
|
C18H21N5O
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0549972
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-(4-phenylpiperazin-1-yl)ethyl]pteridin-7-one
Show/Hide
|
C23H25N7O2
|
1
|
| 1 |
IC50 = 49.2 nM
|
|
|
|
CP0163764
|
5-Butyl-8-(3-chloro-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C16H15ClN6
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0577554
|
2-amino-8-[2-[4-(3-fluorophenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H24FN7O2
|
1
|
| 1 |
IC50 = 57.5 nM
|
|
|
|
CP0104551
|
4-(5-Butyl-3H-[1,2,4]triazolo[5,1-i]purin-8-yl)-phenol
Show/Hide
|
C16H16N6O
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0571544
|
2-amino-8-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H24FN7O2
|
1
|
| 1 |
IC50 = 58.8 nM
|
|
|
|
CP0551514
|
2-amino-8-[2-[4-[4-(difluoromethoxy)phenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C24H25F2N7O3
|
1
|
| 1 |
IC50 = 63.7 nM
|
|
|
|
CP0186843
|
5-Butyl-8-(3-methoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H18N6O
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0545457
|
1-amino-N-(pyridin-2-ylmethyl)pyrazino[1,2-a]benzimidazole-3-carboxamide
Show/Hide
|
C17H14N6O
|
1
|
| 1 |
IC50 = 69.9 nM
|
|
|
|
CP0466568
|
2,7-bis(furan-2-yl)-1,3-benzoxazol-5-amine
Show/Hide
|
C15H10N2O3
|
1
|
| 1 |
IC50 = 70.6 nM
|
|
|
|
CP0163517
|
5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C16H16N6
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0053494
|
4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol
Show/Hide
|
C16H15N7O2
|
6
|
| 1 |
IC50 = 80.8 nM
|
|
|
| 2 |
Kd = 0.5012 nM
|
|
|
| 3 |
Ki = 0.1 nM
|
|
|
| 4 |
Ki = 0.4 nM
|
|
|
| 5 |
Ki = 1.995 nM
|
|
|
| 6 |
Ki = 64 nM
|
|
|
|
CP0532874
|
CPI-444
Show/Hide
|
C20H21N7O3
|
2
|
| 1 |
IC50 = 86.5 nM
|
|
|
| 2 |
IC50 = 3353 nM
|
|
|
|
CP0574695
|
2-amino-8-[2-[4-(2-chloro-4-fluorophenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H23ClFN7O2
|
1
|
| 1 |
IC50 = 86.5 nM
|
|
|
|
CP0231050
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]-2-(4-methylsulfonylphenyl)acetamide
Show/Hide
|
C23H22N6O3S
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0079106
|
8-Phenyl-5-propyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C15H14N6
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0538799
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-[4-(trifluoromethoxy)phenyl]piperazin-1-yl]ethyl]pteridin-7-one
Show/Hide
|
C24H24F3N7O3
|
1
|
| 1 |
IC50 = 120.2 nM
|
|
|
|
CP0492267
|
5-Butyl-2-(2-chloro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H15ClN6
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0857945
|
3-(4-(2-(6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-8,9-dihydro-7H-purin-2-ylamino)ethyl)phenyl)propanoic acid
Show/Hide
|
C23H31N7O6
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
Ki = 79 nM
|
|
|
|
CP0570360
|
1-amino-N-(pyridin-3-ylmethyl)pyrazino[1,2-a]benzimidazole-3-carboxamide
Show/Hide
|
C17H14N6O
|
1
|
| 1 |
IC50 = 171.6 nM
|
|
|
|
CP0549974
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]pteridin-7-one
Show/Hide
|
C24H24F3N7O2
|
1
|
| 1 |
IC50 = 175.9 nM
|
|
|
|
CP0298635
|
5-Butyl-8-p-tolyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H18N6
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0195839
|
5-Butyl-8-m-tolyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H18N6
|
1
|
| 1 |
IC50 = 188 nM
|
|
|
|
CP0488154
|
5-Butyl-2-phenyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H16N6
|
2
|
| 1 |
IC50 = 190 nM
|
|
|
| 2 |
IC50 > 190 nM
|
|
|
|
CP0229698
|
5-Pentyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H18N6
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0488672
|
2-amino-4-(5-methylfuran-2-yl)-8-(2-phenylethyl)pteridin-7-one
Show/Hide
|
C19H17N5O2
|
1
|
| 1 |
IC50 = 208 nM
|
|
|
|
CP0330211
|
5-Butyl-8-furan-2-yl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C14H14N6O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0575723
|
2-amino-8-[2-[4-(5-methoxypyridin-2-yl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C23H26N8O3
|
1
|
| 1 |
IC50 = 213 nM
|
|
|
|
CP0574696
|
2-amino-8-[2-[(3S)-4-(4-methoxyphenyl)-3-methylpiperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H29N7O3
|
1
|
| 1 |
IC50 = 223.6 nM
|
|
|
|
CP0561740
|
N-[7-amino-2-(furan-2-yl)-1,3-benzoxazol-5-yl]-2-piperidin-1-ylacetamide
Show/Hide
|
C18H20N4O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0397724
|
US9133197, 3
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
IC50 = 260 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0058033
|
1,3-dipropyl-8-cyclopentylxanthine
Show/Hide
|
C16H24N4O2
|
4
|
| 1 |
IC50 = 261 nM
|
|
|
| 2 |
Ki = 56 nM
|
|
|
| 3 |
Ki = 129 nM
|
|
|
| 4 |
Ki = 130 nM
|
|
|
|
CP0573103
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-(1-phenylpiperidin-4-yl)ethyl]pteridin-7-one
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 279 nM
|
|
|
|
CP0573885
|
2-amino-8-[2-[(2R)-4-(4-methoxyphenyl)-2-methylpiperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H29N7O3
|
1
|
| 1 |
IC50 = 296.1 nM
|
|
|
|
CP0564551
|
US10988455, Example 1(xcv)
Show/Hide
|
C15H11ClFN5
|
1
|
| 1 |
IC50 = 298.8 nM
|
|
|
|
CP0409696
|
5-Ethyl-2-phenyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C14H12N6
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0035888
|
5-Ethyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C14H12N6
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0576801
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-(4-phenylpiperidin-1-yl)ethyl]pteridin-7-one
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 387.8 nM
|
|
|
|
CP0404529
|
US9133197, 4
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
IC50 = 420 nM
|
|
|
| 2 |
Ki = 7.5 nM
|
|
|
|
CP0028721
|
2-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C12H16N8
|
3
|
| 1 |
IC50 = 430 nM
|
|
|
| 2 |
Ki = 6.6 nM
|
|
|
| 3 |
Ki = 10.7 nM
|
|
|
|
CP0124553
|
4-[6-amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-ol
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
IC50 = 450 nM
|
|
|
| 2 |
Ki = 8.4 nM
|
|
|
|
CP0579700
|
2-amino-8-[(3-methoxyphenyl)methyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C19H17N5O3
|
1
|
| 1 |
IC50 = 475.7 nM
|
|
|
|
CP0542972
|
2-amino-8-benzyl-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C18H15N5O2
|
1
|
| 1 |
IC50 = 481.7 nM
|
|
|
|
CP0536610
|
N-[2,7-bis(furan-2-yl)-1,3-benzoxazol-5-yl]-2-piperidin-1-ylacetamide
Show/Hide
|
C22H21N3O4
|
1
|
| 1 |
IC50 = 486 nM
|
|
|
|
CP0571543
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]pteridin-7-one
Show/Hide
|
C24H24F3N7O2
|
1
|
| 1 |
IC50 = 502.8 nM
|
|
|
|
CP0044678
|
5-Butyl-8-(4-fluoro-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C16H15FN6
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0056273
|
5-Methyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C13H10N6
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0571547
|
2-amino-8-[2-[3-(4-methoxyphenyl)-3,8-diazabicyclo[3.2.1]octan-8-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C26H29N7O3
|
1
|
| 1 |
IC50 = 554.7 nM
|
|
|
|
CP0573105
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-(4-phenoxyphenyl)piperazin-1-yl]ethyl]pteridin-7-one
Show/Hide
|
C29H29N7O3
|
1
|
| 1 |
IC50 = 604.8 nM
|
|
|
|
CP0551513
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-[2-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]pteridin-7-one
Show/Hide
|
C24H24F3N7O2
|
1
|
| 1 |
IC50 = 612.6 nM
|
|
|
|
CP0564552
|
1-amino-N-(2-pyridin-2-ylethyl)pyrazino[1,2-a]benzimidazole-3-carboxamide
Show/Hide
|
C18H16N6O
|
1
|
| 1 |
IC50 = 646.8 nM
|
|
|
|
CP0579642
|
2-amino-4-(5-methylfuran-2-yl)-8-(3-phenylpropyl)pteridin-7-one
Show/Hide
|
C20H19N5O2
|
1
|
| 1 |
IC50 = 712 nM
|
|
|
|
CP0551523
|
2-amino-8-[2-[4-(4-methoxyphenyl)-1,4-diazepan-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H29N7O3
|
1
|
| 1 |
IC50 = 715.8 nM
|
|
|
|
CP0181915
|
1-[2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-ethyl]-imidazolidin-2-one
Show/Hide
|
C19H22N6O
|
1
|
| 1 |
IC50 = 725 nM
|
|
|
|
CP0527672
|
5-Butyl-2-(3-chloro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H15ClN6
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
|
CP0059697
|
5-Butyl-8-pyridin-3-yl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C15H15N7
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0577553
|
2-amino-4-(5-methylfuran-2-yl)-8-(4-phenylbutyl)pteridin-7-one
Show/Hide
|
C21H21N5O2
|
1
|
| 1 |
IC50 = 979.8 nM
|
|
|
|
CP0056974
|
4-[6-amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-one
Show/Hide
|
C12H14N8O
|
2
|
| 1 |
IC50 = 990 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0069838
|
(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
Show/Hide
|
C26H26N6O4
|
3
|
| 1 |
IC50 = 1000 nM
|
|
|
| 2 |
Ki = 500 nM
|
|
|
| 3 |
Ki = 503 nM
|
|
|
|
CP0577870
|
2-amino-8-(cyclopropylmethyl)-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C15H15N5O2
|
1
|
| 1 |
IC50 = 1010 nM
|
|
|
|
CP0577869
|
2-amino-8-[(2-methoxyphenyl)methyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C19H17N5O3
|
1
|
| 1 |
IC50 = 1016 nM
|
|
|
|
CP0549971
|
2-amino-9-benzyl-6-(5-methylfuran-2-yl)-7H-purin-8-one
Show/Hide
|
C17H15N5O2
|
1
|
| 1 |
IC50 = 1030 nM
|
|
|
|
CP0564553
|
1-amino-N-(pyridin-4-ylmethyl)pyrazino[1,2-a]benzimidazole-3-carboxamide
Show/Hide
|
C17H14N6O
|
1
|
| 1 |
IC50 = 1059 nM
|
|
|
|
CP0106716
|
5-Butyl-8-(4-methoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H18N6O
|
2
|
| 1 |
IC50 = 1600 nM
|
|
|
| 2 |
Ki = 892 nM
|
|
|
|
CP0111380
|
4-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanol
Show/Hide
|
C20H24N4O
|
1
|
| 1 |
IC50 = 1618 nM
|
|
|
|
CP0573883
|
2-amino-8-(cyclohexylmethyl)-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C18H21N5O2
|
1
|
| 1 |
IC50 = 1877 nM
|
|
|
|
CP0101157
|
(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-4-ylmethyl-amine
Show/Hide
|
C20H19N5
|
1
|
| 1 |
IC50 = 2010 nM
|
|
|
|
CP0532875
|
2-amino-8-[2-[(2S,5R)-4-(4-methoxyphenyl)-2,5-dimethylpiperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C26H31N7O3
|
1
|
| 1 |
IC50 = 2022 nM
|
|
|
|
CP0101857
|
US9133197, 1
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
IC50 = 2100 nM
|
|
|
| 2 |
Ki = 53 nM
|
|
|
|
CP0181977
|
(R)-3-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-azepan-2-one
Show/Hide
|
C20H23N5O
|
1
|
| 1 |
IC50 = 2108 nM
|
|
|
|
CP0579661
|
2-amino-8-(furan-2-ylmethyl)-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C16H13N5O3
|
1
|
| 1 |
IC50 = 2171 nM
|
|
|
|
CP0214627
|
US9133197, 5
Show/Hide
|
C12H16N8O
|
2
|
| 1 |
IC50 = 2300 nM
|
|
|
| 2 |
Ki = 22 nM
|
|
|
|
CP0371451
|
5-Butyl-8-(3,4,5-trimethoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C19H22N6O3
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0306273
|
5-Butyl-8-(4-chloro-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C16H15ClN6
|
2
|
| 1 |
IC50 = 2600 nM
|
|
|
| 2 |
IC50 > 2600 nM
|
|
|
|
CP0432913
|
5-Butyl-2-(4-methoxy-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H18N6O
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0134270
|
(S)-2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-methyl-pentan-1-ol
Show/Hide
|
C20H26N4O
|
1
|
| 1 |
IC50 = 2684 nM
|
|
|
|
CP0451750
|
5-Butyl-2-(4-ethoxy-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C18H20N6O
|
1
|
| 1 |
IC50 = 2700 nM
|
|
|
|
CP0573894
|
2-amino-9-benzyl-7-methyl-6-(5-methylfuran-2-yl)purin-8-one
Show/Hide
|
C18H17N5O2
|
1
|
| 1 |
IC50 = 2835 nM
|
|
|
|
CP0185297
|
(1R,2R)-2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-indan-1-ol
Show/Hide
|
C23H22N4O
|
1
|
| 1 |
IC50 = 3218 nM
|
|
|
|
CP0259454
|
8-(4-Bromo-phenyl)-5-butyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C16H15BrN6
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
|
CP0376796
|
3-amino-6-chloro-N-(diaminomethylidene)-5-[2-(4-ethoxyphenyl)ethylamino]pyrazine-2-carboxamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C18H21ClF3N7O4
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0037138
|
5-Butyl-8-(4-ethoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C18H20N6O
|
2
|
| 1 |
IC50 = 3800 nM
|
|
|
| 2 |
Ki = 572 nM
|
|
|
|
CP0575720
|
2-amino-8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C24H27N7O3
|
1
|
| 1 |
IC50 = 3810.5 nM
|
|
|
|
CP0183338
|
(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-((R)-1-phenyl-ethyl)-amine
Show/Hide
|
C22H22N4
|
1
|
| 1 |
IC50 = 3876 nM
|
|
|
|
CP0403271
|
3-amino-6-chloro-N-(diaminomethylidene)-5-[2-(4-methoxyphenyl)ethylamino]pyrazine-2-carboxamide;hydrochloride
Show/Hide
|
C15H19Cl2N7O2
|
1
|
| 1 |
IC50 = 4400 nM
|
|
|
|
CP0110087
|
CAS_1794
Show/Hide
|
C12H18ClN7O
|
1
|
| 1 |
IC50 = 5100 nM
|
|
|
|
CP0399729
|
4-(5-Butyl-[1,2,4]triazolo[1,5-c]quinazolin-2-yl)-phenol
Show/Hide
|
C19H18N4O
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0386463
|
3-amino-5-[2-(1,3-benzodioxol-5-yl)ethylamino]-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride
Show/Hide
|
C15H17Cl2N7O3
|
1
|
| 1 |
IC50 = 5600 nM
|
|
|
|
CP0045100
|
5-Hexyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C18H20N6
|
1
|
| 1 |
IC50 = 7800 nM
|
|
|
|
CP0445460
|
3-amino-6-chloro-N-(diaminomethylidene)-5-[2-(3-methoxyphenyl)ethylamino]pyrazine-2-carboxamide;hydrochloride
Show/Hide
|
C15H19Cl2N7O2
|
1
|
| 1 |
IC50 = 8100 nM
|
|
|
|
CP0306274
|
5-Butyl-8-(4-trifluoromethyl-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H15F3N6
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki = 31 nM
|
|
|
|
CP0337596
|
8-Biphenyl-4-yl-5-butyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C22H20N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0372284
|
5-Butyl-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H18N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0373629
|
2-Biphenyl-4-yl-5-butyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C22H20N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0374666
|
5-Butyl-2-(4-fluoro-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17FN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0375149
|
5-Butyl-9-chloro-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0376682
|
2-(4-Bromo-phenyl)-5-butyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17BrN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0383677
|
5-Butyl-8-chloro-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0383693
|
5-Butyl-9-chloro-2-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H16Cl2N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0399680
|
5-(8-Biphenyl-4-yl-3H-[1,2,4]triazolo[5,1-i]purin-5-yl)-pentanoic acid
Show/Hide
|
C23H20N6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0399696
|
5-Butyl-2-p-tolyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H18N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0399728
|
5-Butyl-2-(4-fluoro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H15FN6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0403741
|
5-Butyl-9-chloro-2-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C20H19ClN4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0405939
|
5-Butyl-2-(4-propyl-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C19H22N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0409161
|
5-Butyl-2-(4-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C20H17F3N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0409500
|
2-(4-Bromo-phenyl)-5-butyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H15BrN6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0415011
|
5-Butyl-2-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C21H22N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0447720
|
5-Butyl-2-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0447721
|
8-Biphenyl-4-yl-5-(2-methoxy-ethyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C21H18N6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0448274
|
3-(8-Biphenyl-4-yl-3H-[1,2,4]triazolo[5,1-i]purin-5-yl)-propionic acid
Show/Hide
|
C21H16N6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0453503
|
5-Butyl-8-chloro-2-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H16Cl2N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0461870
|
5-Butyl-2-(4-trifluoromethyl-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H15F3N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0467086
|
5-Butyl-8-chloro-2-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C20H19ClN4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0471941
|
5-Butyl-2-(4-chloro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H15ClN6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0488144
|
4-[8-(4-Chloro-phenyl)-3H-[1,2,4]triazolo[5,1-i]purin-5-yl]-butyric acid
Show/Hide
|
C16H13ClN6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0492838
|
5-Butyl-2-p-tolyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C20H20N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0493534
|
5-Butyl-10-chloro-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0494587
|
5-Butyl-2-(4-ethyl-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C18H20N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0496700
|
5-Butyl-2-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C20H20N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0497284
|
5-Butyl-8-methyl-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C20H20N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0498250
|
2-(4-Bromo-phenyl)-5-butyl-9-chloro-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H16BrClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0502421
|
2-Biphenyl-4-yl-5-butyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C25H22N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0504196
|
5-Butyl-2-(4-tert-butyl-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C20H24N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0509127
|
4-(8-Biphenyl-4-yl-3H-[1,2,4]triazolo[5,1-i]purin-5-yl)-butyric acid
Show/Hide
|
C22H18N6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0795225
|
1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylaminocarbonyl)oxime
Show/Hide
|
C19H16N2O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0542975
|
2-amino-8-[2-[3-(4-methoxy-N-methylanilino)azetidin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C24H27N7O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0544580
|
2-amino-4-(5-methylfuran-2-yl)-8-[(1-phenylpiperidin-4-yl)methyl]pteridin-7-one
Show/Hide
|
C23H24N6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0546340
|
2-amino-4-(5-methylfuran-2-yl)-8-[[3-(trifluoromethyl)phenyl]methyl]pteridin-7-one
Show/Hide
|
C19H14F3N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0571548
|
7-benzyl-4-(5-methylfuran-2-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amine
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0571549
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-[2-(trifluoromethoxy)phenyl]piperazin-1-yl]ethyl]pteridin-7-one
Show/Hide
|
C24H24F3N7O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0571550
|
2-amino-8-[2-[[1-(4-methoxyphenyl)pyrrolidin-3-yl]-methylamino]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H29N7O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0573106
|
2-amino-8-[2-(4-cyclopentylpiperazin-1-yl)ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0573886
|
2-amino-8-benzyl-4-(5-methylfuran-2-yl)-5,7-dihydropteridin-6-one
Show/Hide
|
C18H17N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0573887
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl]ethyl]pteridin-7-one
Show/Hide
|
C24H24F3N7O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0573888
|
2-amino-8-[2-[(1S,4S)-5-(4-methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H27N7O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0574697
|
2-amino-8-[(4-methoxyphenyl)methyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C19H17N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0575725
|
2-amino-4-(5-methylfuran-2-yl)-8-[2-(4-methylpiperazin-1-yl)ethyl]pteridin-7-one
Show/Hide
|
C18H23N7O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0579644
|
2-amino-8-[2-[3-(4-methoxy-N-methylanilino)pyrrolidin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
Show/Hide
|
C25H29N7O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0447991
|
2-Phenyl-5-propyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C15H14N6
|
1
|
| 1 |
IC50 > 120 nM
|
|
|
|
CP0492338
|
5-Butyl-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C17H16N4O
|
1
|
| 1 |
IC50 > 650 nM
|
|
|
|
CP0437767
|
2-Amino-4,6-di-furan-2-yl-nicotinonitrile
Show/Hide
|
C14H9N3O2
|
2
|
| 1 |
Kd = 0.1349 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0035607
|
2-furan-2-yl-7-(2-{4-[4-(2-methoxy-ethoxy)-phenyl]-piperazin-1-yl}-ethyl)-2,7-dihydro-3H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C25H29N9O3
|
3
|
| 1 |
Kd = 0.3162 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
| 3 |
Ki = 1.585 nM
|
|
|
|
CP0482859
|
[4-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-2-nitrophenyl] 5-azidopentanoate
Show/Hide
|
C34H40N12O9
|
2
|
| 1 |
Kd = 3.15 nM
|
|
|
| 2 |
Ki = 4360 nM
|
|
|
|
CP0041258
|
(CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmethyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid
Show/Hide
|
C23H29N7O6
|
3
|
| 1 |
Kd = 4.36 nM
|
|
|
| 2 |
Ki = 27 nM
|
|
|
| 3 |
Ki = 70 nM
|
|
|
|
CP0398223
|
[4-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-2-nitrophenyl] acetate
Show/Hide
|
C31H35N9O9
|
2
|
| 1 |
Kd = 5.04 nM
|
|
|
| 2 |
Ki = 23 nM
|
|
|
|
CP0455518
|
[3-[4-amino-6-(2-hydroxyphenyl)-1,3,5-triazin-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C21H22N6O2
|
3
|
| 1 |
Kd = 12.59 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
| 3 |
Ki = 1.023 nM
|
|
|
|
CP0104008
|
N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C21H28N6O4
|
3
|
| 1 |
Kd = 19.95 nM
|
|
|
| 2 |
Ki = 18.4 nM
|
|
|
| 3 |
Ki = 25.12 nM
|
|
|
|
CP0377664
|
2-[4-amino-6-(5-fluoro-1,3-dihydroisoindol-2-yl)-1,3,5-triazin-2-yl]phenol
Show/Hide
|
C17H14FN5O
|
2
|
| 1 |
Kd = 1000 nM
|
|
|
| 2 |
Ki = 12.59 nM
|
|
|
|
CP0130086
|
8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H24N4O4
|
6
|
| 1 |
Kd = 1258.93 nM
|
|
|
| 2 |
Ki = 2.2 nM
|
|
|
| 3 |
Ki = 6 nM
|
|
|
| 4 |
Ki = 47.4 nM
|
|
|
| 5 |
Ki = 91.2 nM
|
|
|
| 6 |
Ki = 199.53 nM
|
|
|
|
CP0042654
|
1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Show/Hide
|
C7H8N4O2
|
3
|
| 1 |
Kd = 3162.28 nM
|
|
|
| 2 |
Ki = 6700 nM
|
|
|
| 3 |
Ki > 10000 nM
|
|
|
|
CP0043620
|
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Show/Hide
|
C8H10N4O2
|
3
|
| 1 |
Kd = 25118.86 nM
|
|
|
| 2 |
Ki = 5011.87 nM
|
|
|
| 3 |
Ki = 23400 nM
|
|
|
|
CP0396039
|
4-[(E)-(4-bromophenyl)methylideneamino]-3-ethyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C13H10BrN3S2
|
1
|
| 1 |
Ki = 0.01 nM
|
|
|
|
CP0508529
|
3-butyl-4-[(E)-(4-fluorophenyl)methylideneamino]-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C15H14FN3S2
|
1
|
| 1 |
Ki = 0.027 nM
|
|
|
|
CP0484715
|
4-[(E)-(4-fluorophenyl)methylideneamino]-3-propyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C14H12FN3S2
|
1
|
| 1 |
Ki = 0.03 nM
|
|
|
|
CP0373116
|
8-(2-Thioxo-7(3-m-chlorophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8ClN5OS2
|
1
|
| 1 |
Ki = 0.038 nM
|
|
|
|
CP0560047
|
5-amino-3-[2-[4-(2-fluoro-4-methoxyphenyl)piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C24H26FN9O3
|
2
|
| 1 |
Ki = 0.06 nM
|
|
|
| 2 |
Ki = 0.4 nM
|
|
|
|
CP0443841
|
4-[(E)-(4-bromophenyl)methylideneamino]-3-(2-phenylethyl)-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C19H14BrN3S2
|
1
|
| 1 |
Ki = 0.067 nM
|
|
|
|
CP0556646
|
5-amino-3-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C23H23F2N9O2
|
2
|
| 1 |
Ki = 0.07 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0496241
|
2,2'-(4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)phenylazanediyl)diethanol
Show/Hide
|
C22H24N8O3
|
1
|
| 1 |
Ki = 0.12 nM
|
|
|
|
CP0377048
|
7-(3-(4-(aminomethyl)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C20H20N8O
|
1
|
| 1 |
Ki = 0.13 nM
|
|
|
|
CP0443843
|
4-[(E)-(4-chlorophenyl)methylideneamino]-3-phenyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C17H10ClN3S2
|
1
|
| 1 |
Ki = 0.14 nM
|
|
|
|
CP0559384
|
5-amino-3-[2-[4-(6-fluoro-2-methyl-1,3-benzoxazol-5-yl)piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C25H25FN10O3
|
2
|
| 1 |
Ki = 0.15 nM
|
|
|
| 2 |
Ki = 0.4 nM
|
|
|
|
CP0470939
|
8-(2-Thioxo-7(3-p-chlorophenyl.)-2-(2-furyl)thiazolo[4,3-e]1, 2 4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8ClN5OS2
|
1
|
| 1 |
Ki = 0.152 nM
|
|
|
|
CP0116393
|
2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H17N7O
|
1
|
| 1 |
Ki = 0.18 nM
|
|
|
|
CP0847208
|
N-{4-[2-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-ethyl]-phenyl}-hydroxylamine
Show/Hide
|
C19H17N9O2
|
1
|
| 1 |
Ki = 0.18 nM
|
|
|
|
CP0460044
|
(5-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzo[d][1,3]dioxole-2,2-diyl)dimethanol
Show/Hide
|
C22H21N7O5
|
1
|
| 1 |
Ki = 0.19 nM
|
|
|
|
CP0373930
|
N-[6-(3,5-dimethoxyphenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C19H21N5O3
|
2
|
| 1 |
Ki = 0.19 nM
|
|
|
| 2 |
Ki = 0.2 nM
|
|
|
|
CP0392930
|
2-[4-[(dimethylamino)methyl]-2-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O4
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0562486
|
2-[4-[(dimethylamino)methyl]phenyl]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C25H28N6O2
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0090222
|
2-amino-8-methoxy-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C20H17N5O2
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0191496
|
2-amino-N-(quinolin-8-ylmethyl)-8-(trifluoromethoxy)quinazoline-4-carboxamide
Show/Hide
|
C20H14F3N5O2
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0475699
|
2-amino-8-methoxy-N-[(6-propan-2-ylpyridin-2-yl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C19H21N5O2
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0519547
|
2-amino-N-[(6-cyclobutylpyridin-2-yl)methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C20H21N5O2
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0519763
|
2-amino-N-[[6-[(2-fluorophenoxy)methyl]pyridin-2-yl]methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C23H20FN5O3
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0315512
|
4-(diethylamino)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methylcyclohexane-1-carboxamide
Show/Hide
|
C24H36N4O3S
|
2
|
| 1 |
Ki = 0.2 nM
|
|
|
| 2 |
Ki = 2.1 nM
|
|
|
|
CP0541174
|
5-amino-8-(furan-2-yl)-1-methyl-3-[2-[4-[4-(oxolan-3-yloxy)phenyl]piperazin-1-yl]ethyl]-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C27H31N9O4
|
2
|
| 1 |
Ki = 0.2 nM
|
|
|
| 2 |
Ki = 0.22 nM
|
|
|
|
CP0541144
|
5-amino-8-(furan-2-yl)-3-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C24H27N9O3
|
2
|
| 1 |
Ki = 0.21 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0383172
|
7-(3-(4-aminophenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H18N8O
|
1
|
| 1 |
Ki = 0.22 nM
|
|
|
|
CP0190420
|
4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1,4-dimethylcyclohexane-1-carboxamide
Show/Hide
|
C21H29N3O4S
|
2
|
| 1 |
Ki = 0.25 nM
|
|
|
| 2 |
Ki = 8.6 nM
|
|
|
|
CP0547791
|
5-amino-3-[2-[4-(4-cyclopropyloxyphenyl)piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C26H29N9O3
|
2
|
| 1 |
Ki = 0.25 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0506356
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(pyrrolidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C20H23N7O
|
1
|
| 1 |
Ki = 0.26 nM
|
|
|
|
CP0541145
|
5-amino-8-(furan-2-yl)-1-methyl-3-[2-[4-[4-(oxan-4-yloxy)phenyl]piperazin-1-yl]ethyl]-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C28H33N9O4
|
2
|
| 1 |
Ki = 0.26 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0427225
|
5-amino-3-[2-[4-[4-(difluoromethoxy)phenyl]piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C24H25F2N9O3
|
2
|
| 1 |
Ki = 0.27 nM
|
|
|
| 2 |
Ki = 1.9 nM
|
|
|
|
CP0063439
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-[[ethyl(methyl)amino]methyl]phenoxy]acetamide
Show/Hide
|
C26H30N6O3
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0360098
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-(ethylaminomethyl)phenoxy]acetamide
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0509952
|
2-[4-[(dimethylamino)methyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0516508
|
2-[4-[(dimethylamino)methyl]-3-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O4
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0396606
|
7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-7-N-methyl-2-(1,3-oxazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C21H23F2N9O
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0396607
|
7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-7-N-methyl-2-(3-methylpyrazin-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C23H26F2N10
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0434295
|
7-N-(cyclopropylmethyl)-7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C25H28F2N8O
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0392548
|
2-amino-7-fluoro-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0234129
|
A2A
Show/Hide
|
C19H26N4O4S
|
2
|
| 1 |
Ki = 0.3 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0408010
|
4-[4-[2-[5-amino-8-(furan-2-yl)-1-methyl-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl]piperazin-1-yl]benzonitrile
Show/Hide
|
C24H24N10O2
|
2
|
| 1 |
Ki = 0.3 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0293183
|
2-(furan-2-yl)-8-phenethyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C18H15N7O
|
1
|
| 1 |
Ki = 0.31 nM
|
|
|
|
CP0287391
|
5-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Show/Hide
|
C20H21F2N9O
|
1
|
| 1 |
Ki = 0.33 nM
|
|
|
|
CP0034930
|
2-[3-[(dimethylamino)methyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0400913
|
2-amino-8-methoxy-N-[[6-(trifluoromethyl)pyridin-2-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C17H14F3N5O2
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0510184
|
2-amino-N-[[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C19H21N5O3
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0408007
|
5-amino-8-(furan-2-yl)-3-[2-[4-[4-(1-methoxypropan-2-yloxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C27H33N9O4
|
2
|
| 1 |
Ki = 0.4 nM
|
|
|
| 2 |
Ki = 1.5 nM
|
|
|
|
CP0237282
|
5-amino-3-[2-[4-[3-fluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-8-(1,3-thiazol-2-yl)-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C25H29FN10O3S
|
2
|
| 1 |
Ki = 0.4 nM
|
|
|
| 2 |
Ki = 1.5 nM
|
|
|
|
CP0541175
|
4-[4-[2-[5-amino-8-(furan-2-yl)-1-methyl-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl]piperazin-1-yl]-2-fluorobenzonitrile
Show/Hide
|
C24H23FN10O2
|
2
|
| 1 |
Ki = 0.4 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0558170
|
5-amino-8-(furan-2-yl)-1-methyl-3-[2-[4-(5-methylpyridin-2-yl)piperazin-1-yl]ethyl]-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C23H26N10O2
|
2
|
| 1 |
Ki = 0.4 nM
|
|
|
| 2 |
Ki = 1.7 nM
|
|
|
|
CP0545842
|
5-amino-8-(furan-2-yl)-3-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C26H31N9O4
|
2
|
| 1 |
Ki = 0.42 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0383040
|
ethyl 2-[4-[2-[7-amino-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]phenoxy]acetate
Show/Hide
|
C22H21N7O4
|
1
|
| 1 |
Ki = 0.43 nM
|
|
|
|
CP0168564
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxypiperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C22H27N7O2
|
1
|
| 1 |
Ki = 0.44 nM
|
|
|
|
CP0399741
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(3-methoxyazetidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
Ki = 0.47 nM
|
|
|
|
CP0371800
|
2-[3-[(dimethylamino)methyl]-5-fluorophenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C25H27FN6O3
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0453415
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-fluoro-5-(pyrrolidin-1-ylmethyl)phenoxy]acetamide
Show/Hide
|
C27H29FN6O3
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0528169
|
2-[3-[2-(dimethylamino)ethyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O3
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0428626
|
7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-2-(furan-2-yl)-7-N-(2-methoxyethyl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C24H28F2N8O2
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0146190
|
2-amino-8-fluoro-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0424501
|
2-amino-8-methoxy-N-[(6-methylpyridin-2-yl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0444068
|
2-amino-N-[[6-(cyclopentyloxymethyl)pyridin-2-yl]methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C22H25N5O3
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0542826
|
5-amino-8-(furan-2-yl)-3-[2-[4-[4-(1-methoxy-2-methylpropan-2-yl)oxyphenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C28H35N9O4
|
2
|
| 1 |
Ki = 0.5 nM
|
|
|
| 2 |
Ki = 2.1 nM
|
|
|
|
CP0545838
|
5-amino-8-(furan-2-yl)-3-[2-[4-[3-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C26H31N9O4
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0386238
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(piperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H25N7O
|
1
|
| 1 |
Ki = 0.56 nM
|
|
|
|
CP0526834
|
8-(2-Thioxo-7(3-p-iodophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8IN5OS2
|
1
|
| 1 |
Ki = 0.57 nM
|
|
|
|
CP0418184
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)-N,N-bis(2-chloroethyl)benzenesulfonamide
Show/Hide
|
C22H22Cl2N8O3S
|
1
|
| 1 |
Ki = 0.59 nM
|
|
|
|
CP0059564
|
N-[2-(furan-2-yl)-6-pyrazol-1-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C13H11N5O2
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0497739
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(2-fluoro-3-methoxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H18FN5O2
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0452702
|
2-amino-N-[[6-(2-hydroxypropan-2-yl)-3-methylpyridin-2-yl]methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C20H23N5O3
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0558169
|
5-amino-3-[2-[4-[3,5-difluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C26H29F2N9O4
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0466764
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(dimethylamino)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C18H21N7O
|
1
|
| 1 |
Ki = 0.61 nM
|
|
|
|
CP0081968
|
2-(3-(aminomethyl)phenoxy)-N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C23H24N6O3
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0276174
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(2,6-dimethylpyridin-4-yl)oxyacetamide
Show/Hide
|
C23H24N6O3
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0396604
|
2-(furan-2-yl)-N7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-N7-(2-methoxyethyl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C27H36N8O4
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0494649
|
3-(5-amino-7-((2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)(methyl)amino)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzonitrile
Show/Hide
|
C28H33N9O2
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0504229
|
8-(2-Thioxo-7(3-o-iodophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8IN5OS2
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0191494
|
2-amino-8-bromo-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14BrN5O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0438359
|
5-amino-3-[2-[4-[3-fluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C26H30FN9O4
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0127357
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H26N8O
|
1
|
| 1 |
Ki = 0.71 nM
|
|
|
|
CP0439413
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-{6-[(2-methoxyethyl)(methyl)amino]pyridin-2-yl}pyrimidin-4-yl]acetamide
Show/Hide
|
C20H25N7O2
|
1
|
| 1 |
Ki = 0.72 nM
|
|
|
|
CP0294067
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)-N,N-bis(2-hydroxyethyl)benzenesulfonamide
Show/Hide
|
C22H24N8O5S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0472160
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[4-(morpholin-4-ylmethyl)phenyl]acetamide
Show/Hide
|
C27H30N6O3
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0428628
|
7-N-(cyclopropylmethyl)-2-(furan-2-yl)-7-N-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C28H36N8O3
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0519546
|
2-amino-8-methoxy-N-[(6-methoxypyridin-2-yl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C17H17N5O3
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0310128
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(morpholin-4-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
Ki = 0.83 nM
|
|
|
|
CP0405015
|
N-[2-(furan-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C18H20N6O2S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0344410
|
2-[2-[(dimethylamino)methyl]-4-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O4
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0437697
|
7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-7-N-ethyl-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C23H26F2N8O
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0541173
|
5-amino-3-[2-[4-[2,5-difluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C26H29F2N9O4
|
2
|
| 1 |
Ki = 0.9 nM
|
|
|
| 2 |
Ki = 1.2 nM
|
|
|
|
CP0427226
|
5-amino-8-(furan-2-yl)-1-methyl-3-[2-[4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazin-1-yl]ethyl]-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C21H21F3N10O2S
|
2
|
| 1 |
Ki = 0.9 nM
|
|
|
| 2 |
Ki = 1.2 nM
|
|
|
|
CP0489914
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-methoxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H19N5O2
|
2
|
| 1 |
Ki = 0.92 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0393512
|
2-(3-fluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H24FN3O4S
|
2
|
| 1 |
Ki = 0.95 nM
|
|
|
| 2 |
Ki = 2.8 nM
|
|
|
|
CP0469720
|
2-(furan-2-yl)-7-(3-(4-nitrophenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H16N8O3
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0371798
|
2-[2-[(dimethylamino)methyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0422346
|
2-[2-[(dimethylamino)methyl]-4-methylphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O3
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0169417
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]-2-(4-methoxyphenyl)acetamide
Show/Hide
|
C23H22N6O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0320317
|
2-(3,5-dimethoxyphenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C24H24N6O3
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0349896
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]-2-(4-ethoxy-3-methoxyphenyl)acetamide
Show/Hide
|
C25H26N6O3
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0492778
|
2-(4-methoxyphenyl)-N-[2-pyridin-2-yl-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C21H17N5O2S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0306029
|
7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-2-(furan-2-yl)-7-N-methyl-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C22H24F2N8O
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0434294
|
7-N-[2-(4-fluorophenyl)ethyl]-2-(furan-2-yl)-7-N-(2-methoxyethyl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C20H21FN6O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0167160
|
(S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluoro-5-(1-methylpyrrolidin-3-yloxy)phenyl)pyrimidin-4-yl)acetamide
Show/Hide
|
C22H25FN6O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0386252
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[3-fluoro-5-(1-methylpyrrolidin-3-yl)oxyphenyl]pyrimidin-4-yl]acetamide
Show/Hide
|
C22H25FN6O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0497964
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[3-(1-methylpiperidin-3-yl)oxyphenyl]pyrimidin-4-yl]acetamide
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0518230
|
2-amino-8-fluoro-N-[[6-(propan-2-yloxymethyl)pyridin-2-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C19H20FN5O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0477674
|
2-(2,6-difluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H23F2N3O4S
|
2
|
| 1 |
Ki = 1 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0447324
|
2,2'-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenylazanediyl)diethanol
Show/Hide
|
C23H26N8O3
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0495886
|
8-(2-Thioxo-7(3-phenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H9N5OS2
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0172465
|
6-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(3,5-dimethylpyrazol-1-yl)-N-pyrazin-2-ylpyrimidin-4-amine
Show/Hide
|
C22H22N8
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0090224
|
2-amino-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H15N5O
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0394429
|
4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methylcyclohexane-1-carboxamide
Show/Hide
|
C20H27N3O4S
|
2
|
| 1 |
Ki = 1.1 nM
|
|
|
| 2 |
Ki = 5.9 nM
|
|
|
|
CP0422897
|
5-amino-8-(furan-2-yl)-1-methyl-3-[2-[4-(4-methylphenyl)piperazin-1-yl]ethyl]-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C24H27N9O2
|
2
|
| 1 |
Ki = 1.1 nM
|
|
|
| 2 |
Ki = 1.4 nM
|
|
|
|
CP0393327
|
2-(furan-2-yl)-7-(3-phenylpropyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H17N7O
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0277159
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[2-(2-morpholin-4-ylethyl)phenoxy]acetamide
Show/Hide
|
C28H32N6O4
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0392932
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-(morpholin-4-ylmethyl)phenoxy]acetamide
Show/Hide
|
C27H30N6O4
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0541171
|
5-amino-3-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-8-(1,3-thiazol-2-yl)-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C25H30N10O3S
|
2
|
| 1 |
Ki = 1.2 nM
|
|
|
| 2 |
Ki = 6.4 nM
|
|
|
|
CP0446709
|
4-(2-amino-4-phenylpyrimidin-5-yl)phenol
Show/Hide
|
C16H13N3O
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0507787
|
4-(2-amino-4-phenylpyrimidin-5-yl)-2-chlorophenol
Show/Hide
|
C16H12ClN3O
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0210709
|
2-Furan-2-yl-N*5*-[3-(4-phenyl-piperazin-1-yl)-propyl]-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Show/Hide
|
C21H25N9O
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0404386
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)benzenesulfonamide
Show/Hide
|
C18H16N8O3S
|
1
|
| 1 |
Ki = 1.31 nM
|
|
|
|
CP0422356
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-fluoro-5-(morpholin-4-ylmethyl)phenoxy]acetamide
Show/Hide
|
C27H29FN6O4
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0522734
|
7-(2-(4-(2,4-difluorophenyl)piperazin-1-yl)ethylthio)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C21H21F2N7OS
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0502494
|
6-Furan-2-yl-9-naphthalen-2-ylmethyl-9H-purin-2-ylamine
Show/Hide
|
C20H15N5O
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0373887
|
2-Amino-4-thiophen-2-yl-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C14H9N3OS
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0189142
|
4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
Show/Hide
|
C15H11ClN4O
|
1
|
| 1 |
Ki = 1.413 nM
|
|
|
|
CP0406452
|
4-[(E)-(4-chlorophenyl)methylideneamino]-3-ethyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C13H10ClN3S2
|
1
|
| 1 |
Ki = 1.44 nM
|
|
|
|
CP0076042
|
(2R,3R,4S,5R)-2-[6-Amino-2-(1-benzyl-1H-pyrazol-4-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C20H21N7O4
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0394856
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-[(dimethylamino)methyl]piperidin-1-yl]acetamide
Show/Hide
|
C24H33N7O2
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0209984
|
7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C21H22F2N8O
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0428624
|
7-N-ethyl-2-(furan-2-yl)-7-N-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C26H34N8O3
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0505330
|
2-(furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethylthio)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C24H29N7O3S
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0400912
|
2-amino-N-[(6-fluoropyridin-2-yl)methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C16H14FN5O2
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0494068
|
2-[4-amino-6-[3-(4-methoxypiperidin-1-yl)phenyl]-1,3,5-triazin-2-yl]phenol
Show/Hide
|
C21H23N5O2
|
1
|
| 1 |
Ki = 1.585 nM
|
|
|
|
CP0496592
|
N-[2-(furan-2-yl)-6-pyrazol-1-ylpyrimidin-4-yl]-2-morpholin-4-ylacetamide
Show/Hide
|
C17H18N6O3
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0428623
|
2-(furan-2-yl)-7-(4-methoxyphenethylthio)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C18H17N5O2S
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0044275
|
9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine
Show/Hide
|
C13H8ClN5O
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0509954
|
2-(3-cyanophenoxy)-N-(2-(pyridin-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C21H14N6O2S
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0124552
|
3-(5-amino-7-((2-(4-(2,4-difluorophenyl)piperazin-1-yl)ethyl)(methyl)amino)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzonitrile
Show/Hide
|
C25H25F2N9
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0514731
|
2-(furan-2-yl)-N7-(4-methoxyphenethyl)-N7-methyl-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0375126
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]propanamide
Show/Hide
|
C18H20N6O2
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0431967
|
4-[(E)-(4-bromophenyl)methylideneamino]-3-propyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C14H12BrN3S2
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0456858
|
2-amino-8-fluoro-N-[(3-oxo-1,2-dihydroisoindol-4-yl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C18H14FN5O2
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0451695
|
2-(3,4-dimethoxyphenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C24H29N3O6S
|
2
|
| 1 |
Ki = 1.8 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0258378
|
8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C12H11N7O
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0514753
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(2-hydroxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0373931
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-hydroxypiperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0427854
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(furan-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C20H25N7O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0153289
|
2-(3,5-dimethoxyphenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0438887
|
2-(3,4-dimethoxyphenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0536137
|
2-[4-(dimethylamino)phenyl]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0522733
|
7-N-[2-(4-fluorophenyl)ethyl]-2-(furan-2-yl)-7-N-methyl-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C18H17FN6O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0431354
|
(S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-methylpyrrolidin-3-yloxy)phenyl)pyrimidin-4-yl)acetamide
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0431369
|
N-[6-(3-cyanophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H16N6O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0474402
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]acetamide
Show/Hide
|
C18H16F3N5O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0497962
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-hydroxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0501844
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-fluoro-5-hydroxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H16FN5O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0515542
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(2-methoxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0541909
|
N-[6-[3-(cyanomethyl)phenyl]-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C19H18N6O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0541912
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[3-(1-methylpyrrolidin-3-yl)oxyphenyl]pyrimidin-4-yl]acetamide
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0551240
|
(R)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluoro-5-(1-methylpyrrolidin-3-yloxy)phenyl)pyrimidin-4-yl)acetamide
Show/Hide
|
C22H25FN6O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0963751
|
2-amino-N-[dideuterio-[6-[dideuterio-[5-(2-methoxyethoxy)-3-pyridyl]methyl]-2-pyridyl]methyl]-8-methoxy-quinazoline-4-carboxamide
Show/Hide
|
C25H26N6O4
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0545843
|
5-amino-3-[2-[4-[4-(2-cyclopropyloxyethoxy)phenyl]piperazin-1-yl]ethyl]-8-(furan-2-yl)-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C28H33N9O4
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0504231
|
8-(2-Thioxo-7(3-p fluorophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8FN5OS2
|
1
|
| 1 |
Ki = 2.02 nM
|
|
|
|
CP0372840
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-3-(dimethylamino)propanamide
Show/Hide
|
C19H24N6O2
|
1
|
| 1 |
Ki = 2.1 nM
|
|
|
|
CP0372841
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]acetamide
Show/Hide
|
C23H31N7O2
|
1
|
| 1 |
Ki = 2.1 nM
|
|
|
|
CP0513773
|
2-(1,3-benzodioxol-5-yloxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C23H25N3O6S
|
2
|
| 1 |
Ki = 2.1 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0520074
|
4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methyl-4-propan-2-ylcyclohexane-1-carboxamide
Show/Hide
|
C23H33N3O4S
|
2
|
| 1 |
Ki = 2.1 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0392931
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-(2-morpholin-4-ylethyl)phenoxy]acetamide
Show/Hide
|
C28H32N6O4
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0272424
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H18N6O2
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0493500
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(1,4-oxazepan-4-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0105793
|
2-amino-N-(quinolin-8-ylmethyl)-8-(trifluoromethyl)quinazoline-4-carboxamide
Show/Hide
|
C20H14F3N5O
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0422562
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-3-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]propanamide
Show/Hide
|
C23H31N7O2
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0330093
|
2-(3,4-difluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H23F2N3O4S
|
2
|
| 1 |
Ki = 2.4 nM
|
|
|
| 2 |
Ki = 6.4 nM
|
|
|
|
CP0427855
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-(ethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0504304
|
2-(furan-2-yl)-N7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-N7-methyl-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C25H32N8O3
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0529755
|
2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropyl)-N-methyl-3H-imidazo[4,5-b]pyridine-5-carboxamide
Show/Hide
|
C23H26N6O3
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0222480
|
2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C13H13N7O
|
1
|
| 1 |
Ki = 2.55 nM
|
|
|
|
CP0464012
|
2-(2,4-difluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H23F2N3O4S
|
2
|
| 1 |
Ki = 2.6 nM
|
|
|
| 2 |
Ki = 7 nM
|
|
|
|
CP0521309
|
4-[(E)-(4-fluorophenyl)methylideneamino]-3-(2-phenylethyl)-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C19H14FN3S2
|
1
|
| 1 |
Ki = 2.64 nM
|
|
|
|
CP0037365
|
N-[2-(furan-2-yl)-6-pyrazol-1-ylpyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C18H21N7O2
|
2
|
| 1 |
Ki = 2.7 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0498519
|
N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H22N4O3
|
1
|
| 1 |
Ki = 2.7 nM
|
|
|
|
CP0198682
|
2-amino-8-fluoro-N-[[3-(4-pyridin-2-ylpiperazine-1-carbonyl)quinolin-8-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C29H25FN8O2
|
1
|
| 1 |
Ki = 2.7 nM
|
|
|
|
CP0434292
|
2-(furan-2-yl)-7-(4-methoxyphenethoxy)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C18H17N5O3
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0505329
|
2-(furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethoxy)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0502492
|
9-(2-Fluoro-4-trifluoromethyl-benzyl)-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C17H11F4N5O
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0510576
|
2-(2-furyl)-6-(1H-pyrazol-1-yl)pyrimidin-4-amine
Show/Hide
|
C11H9N5O
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0427857
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-{4-[(dimethylamino)methyl]piperidin-1-yl}acetamide
Show/Hide
|
C24H33N7O2
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0373932
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-hydroxypyridin-3-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C16H16N6O2
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0320318
|
2-(3,5-dimethylphenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C24H24N6O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0398978
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(3-fluoro-4-methoxyphenyl)acetamide
Show/Hide
|
C23H22FN5O3
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0472161
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methoxy-3-methylphenyl)acetamide
Show/Hide
|
C24H25N5O3
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0504303
|
7-N-ethyl-7-N-[2-(4-fluorophenyl)ethyl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C19H19FN6O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0497963
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[3-(1-ethylpyrrolidin-3-yl)oxyphenyl]pyrimidin-4-yl]acetamide
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0522742
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[3-(1-propan-2-ylpyrrolidin-3-yl)oxyphenyl]pyrimidin-4-yl]acetamide
Show/Hide
|
C24H30N6O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0528329
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-fluoro-2-methoxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H18FN5O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0373934
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[5-(morpholin-4-yl)pyridin-3-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0174914
|
3-[6-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-1-methylindazol-3-yl]imidazo[1,2-a]pyridine-6-carbonitrile
Show/Hide
|
C23H22N6O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0518263
|
US9029393, 97
Show/Hide
|
C23H24FN5O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0235404
|
2-amino-8-chloro-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14ClN5O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0463838
|
2-amino-8-methoxy-N-[(3-methoxypyridin-2-yl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C17H17N5O3
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0386165
|
[3-(4-methyl-1,3-thiazol-2-yl)-4-oxo-6-propylchromen-7-yl] acetate
Show/Hide
|
C18H17NO4S
|
2
|
| 1 |
Ki = 3.09 nM
|
|
|
| 2 |
Ki = 3.162 nM
|
|
|
|
CP0461496
|
9-(2-Benzenesulfonylmethyl-benzyl)-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C23H19N5O3S
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0386239
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[5-(2-methoxyethoxy)pyridin-3-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C19H22N6O3
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0454515
|
2-(3-cyanobenzamido)-N,N-diethyl-1-(3-methoxypropyl)-1H-benzo[d]imidazole-6-carboxamide
Show/Hide
|
C24H27N5O3
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0123308
|
2-amino-8-iodo-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14IN5O
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0424858
|
2-amino-N-[(1-ethylbenzimidazol-4-yl)methyl]-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C19H17FN6O
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0440789
|
5-amino-8-(furan-2-yl)-1-methyl-3-[2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C24H24F3N9O2
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0015755
|
9-Methyl-2-pentyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C13H18N8
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
|
CP0083160
|
2-(4-fluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H23FN4O4S
|
2
|
| 1 |
Ki = 3.4 nM
|
|
|
| 2 |
Ki = 6.5 nM
|
|
|
|
CP0073596
|
6-[2-methyl-6-(trifluoromethyl)pyridin-4-yl]-5-phenyl-1,2,4-triazin-3-amine
Show/Hide
|
C16H12F3N5
|
1
|
| 1 |
Ki = 3.467 nM
|
|
|
|
CP0487242
|
2-[4-amino-6-[(E)-2-(3-methylthiophen-2-yl)ethenyl]-1,3,5-triazin-2-yl]phenol
Show/Hide
|
C16H14N4OS
|
1
|
| 1 |
Ki = 3.467 nM
|
|
|
|
CP0507723
|
8-(2-Thioxo-7(3-ethyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C12H9N5OS2
|
1
|
| 1 |
Ki = 3.56 nM
|
|
|
|
CP0496626
|
2-(3-fluorophenoxy)-N-(2-(pyridin-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C20H14FN5O2S
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0403158
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-acetylpiperazin-1-yl)acetamide
Show/Hide
|
C22H27N7O3
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0105797
|
2-amino-6,7-difluoro-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H13F2N5O
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0384021
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4,6-dimethylpyrimidin-2-yl)oxyacetamide
Show/Hide
|
C22H23N7O3
|
1
|
| 1 |
Ki = 3.7 nM
|
|
|
|
CP0422355
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(3-fluorophenoxy)acetamide
Show/Hide
|
C22H20FN5O3
|
1
|
| 1 |
Ki = 3.7 nM
|
|
|
|
CP0433201
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
Ki = 3.7 nM
|
|
|
|
CP0422166
|
2-(furan-2-yl)-7-(4-(4-methylpiperazin-1-ylsulfonyl)phenethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C23H25N9O3S
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0433200
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-(ethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0434543
|
2-(furan-2-yl)-5-N-[2-(4-phenylpiperidin-1-yl)ethyl]-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Show/Hide
|
C21H24N8O
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0124907
|
6-(3,5-dichlorophenyl)-5-phenyl-1,2,4-triazin-3-amine
Show/Hide
|
C15H10Cl2N4
|
1
|
| 1 |
Ki = 3.981 nM
|
|
|
|
CP0408894
|
4-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester
Show/Hide
|
C22H21N7O3
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0528085
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)acetamide
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0372835
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0423772
|
(R)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-methylpyrrolidin-3-yloxy)phenyl)pyrimidin-4-yl)acetamide
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0488142
|
N-[6-(3,5-difluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H15F2N5O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0467978
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]-2-(morpholin-4-yl)acetamide
Show/Hide
|
C21H25N7O3
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0474791
|
2-(cyclopropylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H19F2N5O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0135718
|
azepan-1-yl-[3-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-1,2-benzoxazol-6-yl]methanone
Show/Hide
|
C21H19FN4O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0474486
|
US9029393, 79
Show/Hide
|
C22H22FN5O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0215618
|
4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2,6-dimethylphenol
Show/Hide
|
C17H16N4O
|
1
|
| 1 |
Ki = 4.074 nM
|
|
|
|
CP0069173
|
2-Furan-2-yl-7-[3-(4-methoxy-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C20H19N7O2
|
1
|
| 1 |
Ki = 4.1 nM
|
|
|
|
CP0437852
|
N-[6-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C20H22N6O
|
1
|
| 1 |
Ki = 4.2 nM
|
|
|
|
CP0323463
|
2-(4-fluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H24FN3O4S
|
2
|
| 1 |
Ki = 4.2 nM
|
|
|
| 2 |
Ki = 13 nM
|
|
|
|
CP0422849
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzimidamide
Show/Hide
|
C20H19N9O
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
|
CP0403160
|
2-[(3S)-3-(diethylamino)pyrrolidin-1-yl]-N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C24H33N7O2
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
|
CP0203919
|
2-amino-6-fluoro-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
|
CP0398883
|
2-amino-N-[[3-(3,4-dihydro-2H-quinoline-1-carbonyl)quinolin-8-yl]methyl]-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C29H23FN6O2
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
|
CP0229610
|
9-(2,6-Difluoro-benzyl)-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C16H11F2N5O
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0541172
|
5-amino-8-(furan-2-yl)-3-[2-[4-(6-methoxypyridin-3-yl)piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C23H26N10O3
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0124908
|
5-(4-fluorophenyl)-6-[2-methyl-6-(trifluoromethyl)pyridin-4-yl]-1,2,4-triazin-3-amine
Show/Hide
|
C16H11F4N5
|
1
|
| 1 |
Ki = 4.571 nM
|
|
|
|
CP0444164
|
2-amino-N-[[6-(hydroxymethyl)pyridin-2-yl]methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C17H17N5O3
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0422758
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzoic acid
Show/Hide
|
C20H17N7O3
|
1
|
| 1 |
Ki = 4.63 nM
|
|
|
|
CP0466883
|
9-Methyl-2-phenethyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C16H16N8
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0040740
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C17H24N6O2
|
2
|
| 1 |
Ki = 4.7 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0454674
|
4-(2-amino-4-phenylpyrimidin-5-yl)benzene-1,2-diol
Show/Hide
|
C16H13N3O2
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0451705
|
2-(3-fluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H23FN4O4S
|
2
|
| 1 |
Ki = 4.7 nM
|
|
|
| 2 |
Ki = 14 nM
|
|
|
|
CP0383255
|
N-[4-[2-[7-amino-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]phenyl]acetamide
Show/Hide
|
C20H18N8O2
|
1
|
| 1 |
Ki = 4.8 nM
|
|
|
|
CP0090223
|
2-amino-8-fluoro-N-[[3-[4-[4-(2-methoxyethoxy)phenyl]piperazine-1-carbonyl]quinolin-8-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C33H32FN7O4
|
1
|
| 1 |
Ki = 4.8 nM
|
|
|
|
CP0398961
|
N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[4-(methanesulfonamido)phenyl]acetamide
Show/Hide
|
C23H24N6O4S
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0472188
|
2-(3,5-difluorophenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C22H19F2N5O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0504997
|
2-(3,4-difluorophenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C22H19F2N5O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0526733
|
N-[6-[3-[2-(dimethylamino)ethoxy]phenyl]-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C21H26N6O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0519762
|
2-amino-8-methoxy-N-[[6-(pyridin-3-ylmethyl)pyridin-2-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C22H20N6O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0454172
|
2-dimethylamino-N-(2-furan-2-yl-6-pyrazol-1-yl-pyrimidin-4-yl)-acetamide
Show/Hide
|
C15H16N6O2
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0134247
|
2-amino-4-(1,3-benzodioxol-5-yl)-6-phenylpyrimidine-5-carbonitrile
Show/Hide
|
C18H12N4O2
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0372833
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(1-methylpiperidin-4-yl)acetamide
Show/Hide
|
C22H28N6O2
|
1
|
| 1 |
Ki = 5.4 nM
|
|
|
|
CP0531388
|
2-amino-N-benzyl-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C16H13FN4O
|
1
|
| 1 |
Ki = 5.4 nM
|
|
|
|
CP0393513
|
N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methyl-2-(4-methylphenoxy)propanamide
Show/Hide
|
C23H27N3O4S
|
2
|
| 1 |
Ki = 5.4 nM
|
|
|
| 2 |
Ki = 8.3 nM
|
|
|
|
CP0375951
|
5-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-2-carboxylic acid ethyl ester
Show/Hide
|
C23H21N7O5
|
1
|
| 1 |
Ki = 5.48 nM
|
|
|
|
CP0446629
|
6-Furan-2-yl-9-naphthalen-1-ylmethyl-9H-purin-2-ylamine
Show/Hide
|
C20H15N5O
|
1
|
| 1 |
Ki = 5.6 nM
|
|
|
|
CP0496627
|
2-[2-[(dimethylamino)methyl]-6-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O4
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0372834
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(morpholin-4-yl)acetamide
Show/Hide
|
C20H24N6O3
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0521485
|
2-(furan-2-yl)-N7-(3-(4-methoxyphenyl)propyl)-N7-methyl-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0396603
|
2-(furan-2-yl)-N7-(4-methoxyphenethyl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C18H18N6O2
|
1
|
| 1 |
Ki = 5.8 nM
|
|
|
|
CP0445403
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]propanamide
Show/Hide
|
C18H26N6O2
|
1
|
| 1 |
Ki = 5.9 nM
|
|
|
|
CP0383256
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)-N'-hydroxybenzimidamide
Show/Hide
|
C20H19N9O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0530721
|
2-(4-methoxyphenyl)-N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C21H18N4O3S
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0372836
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(1,4-oxazepan-4-yl)acetamide
Show/Hide
|
C21H26N6O3
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0437695
|
7-(2-(4-(2,4-difluorophenyl)piperazin-1-yl)ethoxy)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C21H21F2N7O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0519866
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[3-(1-methylpiperidin-4-yl)oxyphenyl]pyrimidin-4-yl]acetamide
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0509963
|
2-(cyclopropylamino)-7-(2-fluoro-6-methoxybenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H22FN5O3
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0851744
|
4-((4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)methyl)benzenesulfonic acid, ammonia salt
Show/Hide
|
C26H26N8O5S
|
1
|
| 1 |
Ki = 6.24 nM
|
|
|
|
CP0523762
|
9-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C17H12ClN5O3
|
1
|
| 1 |
Ki = 6.3 nM
|
|
|
|
CP0866817
|
2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(5-aminopentyl)acetamide
Show/Hide
|
C26H31N9O3
|
1
|
| 1 |
Ki = 6.36 nM
|
|
|
|
CP0905099
|
2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(4-aminobutyl)acetamide
Show/Hide
|
C25H29N9O3
|
1
|
| 1 |
Ki = 6.46 nM
|
|
|
|
CP0083962
|
2-amino-6,8-dichloro-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H13Cl2N5O
|
1
|
| 1 |
Ki = 6.6 nM
|
|
|
|
CP0392538
|
2-amino-8-fluoro-N-(isoquinolin-1-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
Ki = 6.7 nM
|
|
|
|
CP0490422
|
2-amino-8-fluoro-N-[(1R)-1-quinolin-8-ylethyl]quinazoline-4-carboxamide
Show/Hide
|
C20H16FN5O
|
1
|
| 1 |
Ki = 6.7 nM
|
|
|
|
CP0509953
|
2-(3-cyanophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C21H15N5O3S
|
1
|
| 1 |
Ki = 6.8 nM
|
|
|
|
CP0541656
|
6-Furan-2-yl-9-(3-phenyl-propyl)-9H-purin-2-ylamine
Show/Hide
|
C18H17N5O
|
1
|
| 1 |
Ki = 6.8 nM
|
|
|
|
CP0422829
|
2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)-N-(2-aminoethyl)acetamide
Show/Hide
|
C23H25N9O3
|
1
|
| 1 |
Ki = 6.8 nM
|
|
|
|
CP0212778
|
2-amino-8-fluoro-N-[[3-(5-phenylpentylcarbamoyl)quinolin-8-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C31H29FN6O2
|
1
|
| 1 |
Ki = 6.9 nM
|
|
|
|
CP0431366
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-methylphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0493245
|
9-(2,6-Dichloro-benzyl)-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C16H11Cl2N5O
|
1
|
| 1 |
Ki = 7.1 nM
|
|
|
|
CP0199235
|
(2R,3R,4S)-2-(6-amino-2-(hex-1-ynyl)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol
Show/Hide
|
C15H19N5O2S
|
1
|
| 1 |
Ki = 7.19 nM
|
|
|
|
CP0454679
|
2-chloro-4-[2-[(4-hydroxycyclohexyl)amino]-4-phenylpyrimidin-5-yl]phenol
Show/Hide
|
C22H22ClN3O2
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
|
CP0438935
|
N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-phenoxyacetamide
Show/Hide
|
C20H16N4O3S
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0462579
|
methyl N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]carbamate
Show/Hide
|
C17H18N6O3
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0384020
|
2-(2-fluorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C20H15FN4O3S
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0474622
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R,4S)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C18H26N6O3
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0406261
|
2-amino-8-fluoro-N-(1,2,3,4-tetrahydroquinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H18FN5O
|
1
|
| 1 |
Ki = 7.6 nM
|
|
|
|
CP0431968
|
4-[(E)-(4-bromophenyl)methylideneamino]-3-butyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C15H14BrN3S2
|
1
|
| 1 |
Ki = 7.61 nM
|
|
|
|
CP0502488
|
2-amino-6-(2-furyl)-9-(4-methoxyphenylmethyl)-9Hpurine
Show/Hide
|
C17H15N5O2
|
1
|
| 1 |
Ki = 7.7 nM
|
|
|
|
CP0472690
|
(R)-3-cyano-N-(3-(3-methoxypropyl)-6-(2-methylpiperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
Ki = 7.7 nM
|
|
|
|
CP0083961
|
2-amino-8-methylsulfanyl-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C20H17N5OS
|
1
|
| 1 |
Ki = 7.7 nM
|
|
|
|
CP0127131
|
6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine
Show/Hide
|
C16H15N5
|
1
|
| 1 |
Ki = 7.762 nM
|
|
|
|
CP0462580
|
ethyl N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]carbamate
Show/Hide
|
C18H20N6O3
|
1
|
| 1 |
Ki = 7.8 nM
|
|
|
|
CP0519764
|
2-amino-8-methoxy-N-[(5-methoxypyridin-2-yl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C17H17N5O3
|
1
|
| 1 |
Ki = 7.8 nM
|
|
|
|
CP0386240
|
N-[6-(6-aminopyridin-2-yl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C16H17N7O
|
1
|
| 1 |
Ki = 7.9 nM
|
|
|
|
CP0423771
|
N-[6-(3,5-dimethylphenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0406262
|
2-amino-8-fluoro-N-(1H-indol-7-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C18H14FN5O
|
1
|
| 1 |
Ki = 8.2 nM
|
|
|
|
CP0406260
|
2-amino-8-fluoro-N-[(3-methylphenyl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C17H15FN4O
|
1
|
| 1 |
Ki = 8.4 nM
|
|
|
|
CP0394855
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(pyrrolidin-1-yl)acetamide
Show/Hide
|
C20H24N6O2
|
1
|
| 1 |
Ki = 8.6 nM
|
|
|
|
CP0506569
|
9-(3-Fluoro-4-trifluoromethyl-benzyl)-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C17H11F4N5O
|
1
|
| 1 |
Ki = 8.7 nM
|
|
|
|
CP0095644
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C19H24N8OS
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0474613
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C17H24N6O2
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0474813
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(2-(thiophen-2-yl)ethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H21F2N5O2S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0374181
|
7-(3-(4-(allyloxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C22H21N7O2
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0377242
|
4-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-yl]-2-methyl-but-3-yn-2-ol
Show/Hide
|
C17H16FN5O
|
1
|
| 1 |
Ki = 9.1 nM
|
|
|
|
CP0257293
|
2-(3,5-dimethylpyrazol-1-yl)-6-pyrazol-1-yl-N-pyridin-2-ylpyrimidin-4-amine
Show/Hide
|
C17H16N8
|
1
|
| 1 |
Ki = 9.2 nM
|
|
|
|
CP0866827
|
2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(3-aminopropyl)acetamide
Show/Hide
|
C24H27N9O3
|
1
|
| 1 |
Ki = 9.29 nM
|
|
|
|
CP0437409
|
1-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-3-(4-methoxy-phenyl)-urea
Show/Hide
|
C21H15ClN6O3
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0437696
|
2-(furan-2-yl)-N7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C24H30N8O3
|
1
|
| 1 |
Ki = 9.5 nM
|
|
|
|
CP0108313
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]-1,3-thiazol-2-amine
Show/Hide
|
C18H23N7OS
|
1
|
| 1 |
Ki = 9.5 nM
|
|
|
|
CP0493376
|
3-cyano-N-(3-(3-methoxypropyl)-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C24H26N6O3
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0397513
|
3-butyl-4-[(E)-(4-chlorophenyl)methylideneamino]-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C15H14ClN3S2
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0566880
|
2-amino-8-fluoro-N-[[6-(hydroxymethyl)pyridin-2-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C16H14FN5O2
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0377249
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclopentanol
Show/Hide
|
C19H18FN5O
|
1
|
| 1 |
Ki = 9.8 nM
|
|
|
|
CP0440861
|
2-(4-methoxyphenyl)-N-[2-(5-methylfuran-2-yl)-6-pyrazol-1-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C21H19N5O3
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0394857
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-[(dimethylamino)methyl]piperidin-1-yl]acetamide
Show/Hide
|
C24H33N7O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0427858
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methyl-1,4-diazepan-1-yl)acetamide
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0404772
|
6-Furan-2-yl-9-(4-isopropyl-benzyl)-9H-purin-2-ylamine
Show/Hide
|
C19H19N5O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0519548
|
2-amino-N-[[6-(2-hydroxypropan-2-yl)-3-methoxypyridin-2-yl]methyl]-8-methoxyquinazoline-4-carboxamide
Show/Hide
|
C20H23N5O4
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0428220
|
2-amino-8-fluoro-N-(naphthalen-1-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C20H15FN4O
|
1
|
| 1 |
Ki = 10.1 nM
|
|
|
|
CP0441352
|
2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetic acid
Show/Hide
|
C21H19N7O4
|
1
|
| 1 |
Ki = 10.2 nM
|
|
|
|
CP0272282
|
6-(2,6-dimethylpyridin-4-yl)-5-(3-fluorophenyl)-1,2,4-triazin-3-amine
Show/Hide
|
C16H14FN5
|
1
|
| 1 |
Ki = 10.47 nM
|
|
|
|
CP0377858
|
2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)-N-(2-((2-aminoethyl)amino)ethyl)acetamide
Show/Hide
|
C25H30N10O3
|
1
|
| 1 |
Ki = 10.7 nM
|
|
|
|
CP0397512
|
3-ethyl-4-[(E)-(4-fluorophenyl)methylideneamino]-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C13H10FN3S2
|
1
|
| 1 |
Ki = 10.98 nM
|
|
|
|
CP0462263
|
1-(6-Amino-8-furan-2-yl-9-methyl-9H-purin-2-ylethynyl)-cyclohexanol
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0438934
|
2-(3-fluorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C20H15FN4O3S
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0412622
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-ethylpiperazin-1-yl)acetamide
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0436314
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]acetamide
Show/Hide
|
C23H31N7O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0502300
|
2-Amino-6-furan-2-yl-4-phenyl-nicotinonitrile
Show/Hide
|
C16H11N3O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0540555
|
(S)-3-cyano-N-(3-(3-methoxypropyl)-6-(2-methylpiperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0395521
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-3,3-dimethylbutan-1-one
Show/Hide
|
C18H24N8O2
|
1
|
| 1 |
Ki = 11.1 nM
|
|
|
|
CP0434293
|
2-(furan-2-yl)-7-(3-(4-methoxyphenyl)propyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H19N5O2
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0873015
|
2-(2-(2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethoxy)ethoxy)ethanaminium 2,2,2-trifluoroacetate
Show/Hide
|
C16H21F3N8O5
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0469282
|
2-(furan-2-yl)-7-(3-(4-propoxyphenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C22H23N7O2
|
1
|
| 1 |
Ki = 11.7 nM
|
|
|
|
CP0113085
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolylurea
Show/Hide
|
C21H20N8O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0169910
|
JMC511730 Compound 1
Show/Hide
|
C21H27N7O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0494653
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(2-oxopyrrolidin-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C15H18N6O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0439356
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[2-(morpholin-4-yl)pyridin-4-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0514727
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-2-ylmethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H20F2N6O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0045912
|
(4-(furan-2-yl)-2-(2-(thiophen-2-yl)ethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C20H16N2O2S2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0381659
|
2-Amino-4-furan-2-yl-6-thiophen-2-yl-nicotinonitrile
Show/Hide
|
C14H9N3OS
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0531867
|
2-(3-cyanobenzamido)-N-ethyl-3-(3-methoxypropyl)-N-methyl-3H-imidazo[4,5-b]pyridine-5-carboxamide
Show/Hide
|
C22H24N6O3
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0159680
|
[4-(azepane-1-carbonyl)phenyl]-(6-fluoroimidazo[1,2-a]pyridin-3-yl)methanone
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0279078
|
2-amino-8-fluoro-N-[[3-[methyl(3-pyridin-2-ylpropyl)carbamoyl]quinolin-8-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C29H26FN7O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0454853
|
2-(3,4-difluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H22F2N4O4S
|
2
|
| 1 |
Ki = 12 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0153688
|
6-Furan-2-yl-9-(3-methoxy-benzyl)-9H-purin-2-ylamine
Show/Hide
|
C17H15N5O2
|
1
|
| 1 |
Ki = 12.3 nM
|
|
|
|
CP0487244
|
2-(4-amino-6-propan-2-yl-1,3,5-triazin-2-yl)phenol
Show/Hide
|
C12H14N4O
|
1
|
| 1 |
Ki = 12.3 nM
|
|
|
|
CP0388549
|
7-(3-(4-(2-fluoroethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C21H20FN7O2
|
1
|
| 1 |
Ki = 12.4 nM
|
|
|
|
CP0383165
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-yl]-3-ethyl-pent-1-yn-3-ol
Show/Hide
|
C19H20FN5O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0402364
|
3-[6-Amino-2-(1-hydroxy-cyclohexylethynyl)-9-methyl-9H-purin-8-yl]-benzonitrile
Show/Hide
|
C21H20N6O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0497771
|
2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropyl)-N-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide
Show/Hide
|
C23H26N6O3
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0454852
|
2-(2,4-difluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H22F2N4O4S
|
2
|
| 1 |
Ki = 13 nM
|
|
|
| 2 |
Ki = 13.5 nM
|
|
|
|
CP0425756
|
2-(furan-2-yl)-7-(3-(4-isopropoxyphenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C22H23N7O2
|
1
|
| 1 |
Ki = 13.3 nM
|
|
|
|
CP0540852
|
2-amino-8-fluoro-N-[(2-methylphenyl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C17H15FN4O
|
1
|
| 1 |
Ki = 13.6 nM
|
|
|
|
CP0509956
|
2-(3-chlorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C20H15ClN4O3S
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0403153
|
N-[6-(5-methyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C20H25N7O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0468345
|
2-amino-8-fluoro-N-(2-pyridin-2-ylethyl)quinazoline-4-carboxamide
Show/Hide
|
C16H14FN5O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0477675
|
2-[3-(2-methoxyethoxy)phenoxy]-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C24H30N4O6S
|
2
|
| 1 |
Ki = 14 nM
|
|
|
| 2 |
Ki = 28 nM
|
|
|
|
CP0504416
|
7-(3-(4-(but-3-en-1-yloxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C23H23N7O2
|
1
|
| 1 |
Ki = 14.4 nM
|
|
|
|
CP0408214
|
1-[6-Amino-8-(2-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol
Show/Hide
|
C20H20FN5O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0372839
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methoxypiperidin-1-yl)acetamide
Show/Hide
|
C22H28N6O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0374544
|
N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C15H19N5O2S
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0388356
|
2-Amino-4-(5-methyl-furan-2-yl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C15H11N3O2
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0388138
|
2-amino-8-fluoro-N-(quinolin-2-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0513771
|
2-(2,6-difluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H22F2N4O4S
|
2
|
| 1 |
Ki = 15 nM
|
|
|
| 2 |
Ki = 26.5 nM
|
|
|
|
CP0878922
|
(Z)-3-(4-((1-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)-2,10,17-trioxo-3,6,9,16-tetraazaoctadecan-18-yl)oxy)styryl)-5,5-difluoro-8-(1Hpyrrol-2-yl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
Show/Hide
|
C54H57BF2N14O6
|
1
|
| 1 |
Ki = 15.1 nM
|
|
|
|
CP0566089
|
propan-2-yl 2-[6-ethyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxochromen-7-yl]oxyacetate
Show/Hide
|
C20H21NO5S
|
1
|
| 1 |
Ki = 15.14 nM
|
|
|
|
CP0233346
|
2-amino-8-fluoro-N-[(4-methoxyquinolin-8-yl)methyl]quinazoline-4-carboxamide
Show/Hide
|
C20H16FN5O2
|
1
|
| 1 |
Ki = 15.2 nM
|
|
|
|
CP0133515
|
9-(5'-Cyclopropylaminocarbonyl-4'-thio-beta-D-ribofuranosyl)-N6-(3-iodo-benzyl)adenine
Show/Hide
|
C20H21IN6O3S
|
1
|
| 1 |
Ki = 15.2 nM
|
|
|
|
CP0146269
|
6-(2,6-dimethylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
Show/Hide
|
C16H14FN5
|
1
|
| 1 |
Ki = 15.49 nM
|
|
|
|
CP0497001
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol
Show/Hide
|
C20H20FN5O
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0533395
|
2-(3-cyanobenzamido)-N,N-diethyl-3-(3-methoxypropyl)-3H-imidazo[4,5-b]pyridine-6-carboxamide
Show/Hide
|
C23H26N6O3
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0109688
|
2-(4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy)-N-(4-fluorophenyl)acetamide
Show/Hide
|
C25H26FN5O4
|
1
|
| 1 |
Ki = 16.6 nM
|
|
|
|
CP0873223
|
(4-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)methyl)cyclohexyl)methanaminium 2,2,2-trifluoroacetate
Show/Hide
|
C18H23F3N8O3
|
1
|
| 1 |
Ki = 16.9 nM
|
|
|
|
CP0403152
|
2-(4-methylpiperazin-1-yl)-N-[6-(1H-pyrazol-1-yl)-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H20N8OS
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0532296
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(4-methoxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0468993
|
3-cyano-N-(1-(3-methoxypropyl)-6-(piperidine-1-carbonyl)-1H-benzo[d]imidazol-2-yl)benzamide
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0385399
|
tert-butyl N-[2-[2-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethoxy]ethoxy]ethyl]carbamate
Show/Hide
|
C19H28N8O5
|
1
|
| 1 |
Ki = 17.8 nM
|
|
|
|
CP0422751
|
1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cycloheptanol
Show/Hide
|
C21H22FN5O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0491371
|
methyl N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]carbamate
Show/Hide
|
C17H24N6O3
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0399709
|
4-amino-2,6-diphenyl-5-pyrimidinecarbonitrile
Show/Hide
|
C17H12N4
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0541910
|
N-[6-(2,5-dimethylphenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0437768
|
2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile
Show/Hide
|
C16H11N3O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0903728
|
7-hydroxy-3-(4-methylthiazol-2-yl)-6-pentyl-4H-chromen-4-one
Show/Hide
|
C18H19NO3S
|
1
|
| 1 |
Ki = 19.95 nM
|
|
|
|
CP0435231
|
N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C15H19N5O2S
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0490423
|
2-amino-N-(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C18H15FN4O3
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0153735
|
6-Furan-2-yl-9-(4-trifluoromethyl-benzyl)-9H-purin-2-ylamine
Show/Hide
|
C17H12F3N5O
|
1
|
| 1 |
Ki = 20.5 nM
|
|
|
|
CP0388115
|
5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine
Show/Hide
|
C19H20N8O
|
1
|
| 1 |
Ki = 20.6 nM
|
|
|
|
CP0106489
|
2-Amino-4-(3-hydroxy-phenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)-pyridine-3,5-dicarbonitrile
Show/Hide
|
C17H12N6OS
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0392209
|
tert-butyl 4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazine-1-carboxylate
Show/Hide
|
C17H22N8O3
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0393555
|
2-(2-fluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H23FN4O4S
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0412862
|
N-[4-(1,3-benzodioxol-5-yl)-5-cyano-6-phenylpyrimidin-2-yl]butanamide
Show/Hide
|
C22H18N4O3
|
1
|
| 1 |
Ki = 21.3 nM
|
|
|
|
CP0073595
|
6-(3,5-dimethylphenyl)-5-phenyl-1,2,4-triazin-3-amine
Show/Hide
|
C17H16N4
|
1
|
| 1 |
Ki = 21.38 nM
|
|
|
|
CP0523761
|
9-(4-Chloro-benzyl)-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C16H12ClN5O
|
1
|
| 1 |
Ki = 21.5 nM
|
|
|
|
CP0388137
|
2-amino-N-(3,4-dihydro-2H-1,4-benzoxazin-8-ylmethyl)-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C18H16FN5O2
|
1
|
| 1 |
Ki = 21.5 nM
|
|
|
|
CP0430643
|
6-Furan-2-yl-9-(2-methoxy-benzyl)-9H-purin-2-ylamine
Show/Hide
|
C17H15N5O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0451704
|
2-[3-(2-methoxyethoxy)phenoxy]-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C25H31N3O6S
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0374955
|
7-(3-(4-(sec-butoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C23H25N7O2
|
1
|
| 1 |
Ki = 22.1 nM
|
|
|
|
CP0412861
|
2-amino-4,6-diphenylpyrimidine-5-carbonitrile
Show/Hide
|
C17H12N4
|
1
|
| 1 |
Ki = 22.7 nM
|
|
|
|
CP0903161
|
2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(6-aminohexyl)acetamide
Show/Hide
|
C27H33N9O3
|
1
|
| 1 |
Ki = 22.8 nM
|
|
|
|
CP0474623
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R,4R)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C18H26N6O3
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0498034
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(methylamino)-7H-purin-8(9H)-one
Show/Hide
|
C20H17F2N5O2
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0154687
|
N-benzyl-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C26H29N5O4
|
1
|
| 1 |
Ki = 23.8 nM
|
|
|
|
CP0388548
|
2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)ethanol
Show/Hide
|
C21H21N7O3
|
1
|
| 1 |
Ki = 23.9 nM
|
|
|
|
CP0079506
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolyl-urea
Show/Hide
|
C22H22N8O2
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0433199
|
2-(4-methylpiperazin-1-yl)-N-[6-(pyridin-2-yl)-2-(thiophen-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C20H22N6OS
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0386671
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0123210
|
2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-N-(2,2,2-trifluoroethyl)pyrimidin-4-amine
Show/Hide
|
C17H23F3N6O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0191495
|
2-amino-8-cyano-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C20H14N6O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0393514
|
N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methyl-2-[3-(trifluoromethyl)phenoxy]propanamide
Show/Hide
|
C22H23F3N4O4S
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0851743
|
(E)-N-(4-(2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)acetamido)butyl)-6-(2-(4-(2-(5,5-difluoro-7-(thiophen-2-yl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)vinyl)phenoxy)acetamido)hexanamide
Show/Hide
|
C54H55BF2N12O6S
|
1
|
| 1 |
Ki = 24.6 nM
|
|
|
|
CP0396605
|
7-N-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-7-N-methyl-2-phenyl-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C27H34N8O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0540553
|
2-(3-cyanobenzamido)-N-ethyl-3-(3-methoxypropyl)-N-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide
Show/Hide
|
C22H24N6O3
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0409344
|
2-amino-N-(1H-benzimidazol-4-ylmethyl)-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C17H13FN6O
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0394424
|
4-ethyl-4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methylcyclohexane-1-carboxamide
Show/Hide
|
C22H31N3O4S
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0851093
|
7-hydroxy-3-(4-methylthiazol-2-yl)-6-propyl-4H-chromen-4-one
Show/Hide
|
C16H15NO3S
|
1
|
| 1 |
Ki = 25.12 nM
|
|
|
|
CP0915077
|
5-methyl-3-(4-methylthiazol-2-yl)-7-(pent-4-ynyloxy)-4H-chromen-4-one
Show/Hide
|
C19H17NO3S
|
1
|
| 1 |
Ki = 25.12 nM
|
|
|
|
CP0372885
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C21H26N8O
|
1
|
| 1 |
Ki = 25.5 nM
|
|
|
|
CP0132091
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)-N-phenylacetamide
Show/Hide
|
C25H27N5O4
|
1
|
| 1 |
Ki = 25.8 nM
|
|
|
|
CP0502363
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C16H22N6O2
|
1
|
| 1 |
Ki = 25.8 nM
|
|
|
|
CP0491373
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-propylpyrrolidin-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H26N6O
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0498979
|
6-Furan-2-yl-9-(2,4,6-trifluoro-benzyl)-9H-purin-2-ylamine
Show/Hide
|
C16H10F3N5O
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0437765
|
2-Amino-4-benzo[1,3]dioxol-5-yl-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C17H11N3O3
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0415260
|
2-amino-8-fluoro-N-(isoquinolin-4-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
Ki = 26.7 nM
|
|
|
|
CP0386237
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C19H24N8OS
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0375019
|
N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-thiophen-2-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C16H20N4O2S
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0394262
|
N-[4-(1,3-benzodioxol-5-yl)-5-cyano-6-phenylpyrimidin-2-yl]cyclopentanecarboxamide
Show/Hide
|
C24H20N4O3
|
1
|
| 1 |
Ki = 27.2 nM
|
|
|
|
CP0385401
|
5-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
Show/Hide
|
C19H19BrN8O
|
1
|
| 1 |
Ki = 27.3 nM
|
|
|
|
CP0197085
|
5-(3,5-difluorophenyl)-6-(2,6-dimethylpyridin-4-yl)-1,2,4-triazin-3-amine
Show/Hide
|
C16H13F2N5
|
1
|
| 1 |
Ki = 27.54 nM
|
|
|
|
CP0474615
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C16H22N6O
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0106488
|
2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)-pyridine-3,5-dicarbonitrile
Show/Hide
|
C17H12N6OS
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0137011
|
2-((1H-imidazol-2-yl)methylthio)-6-amino-4-phenylpyridine-3,5-dicarbonitrile
Show/Hide
|
C17H12N6S
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0454851
|
2-(4-chlorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H23ClN4O4S
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0047375
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolyl-urea
Show/Hide
|
C20H18N8O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0895926
|
triethylamine hemi(5-(4-(2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetamido)butylcarbamoyl)-2-(6-amino-3-iminio-4,5-disulfonato-3H-xanthen-9-yl)benzoate)
Show/Hide
|
C58H71N13O13S2
|
1
|
| 1 |
Ki = 30.3 nM
|
|
|
|
CP0116391
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-trifluoromethyl-phenyl)-urea
Show/Hide
|
C22H19F3N8O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0514726
|
7-(2,6-difluorobenzyl)-2-(ethylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C21H19F2N5O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0469796
|
2-(furan-2-yl)-5-N-[2-(4-methylpiperazin-1-yl)ethyl]-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Show/Hide
|
C15H21N9O
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0481595
|
[5-methyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxochromen-7-yl] acetate
Show/Hide
|
C16H13NO4S
|
2
|
| 1 |
Ki = 31.62 nM
|
|
|
| 2 |
Ki = 33.88 nM
|
|
|
|
CP0895697
|
7-hydroxy-3-(2-methylthiazol-4-yl)-6-propyl-4H-chromen-4-one
Show/Hide
|
C16H15NO3S
|
1
|
| 1 |
Ki = 31.62 nM
|
|
|
|
CP0309159
|
2-Amino-4,6-di-thiophen-2-yl-nicotinonitrile
Show/Hide
|
C14H9N3S2
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0123982
|
4-chloro-N-(5-cyano-4,6-diphenylpyrimidin-2-yl)benzamide
Show/Hide
|
C24H15ClN4O
|
1
|
| 1 |
Ki = 32.9 nM
|
|
|
|
CP0514725
|
2-(cyclopropylamino)-7-(2-fluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H20FN5O2
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0277567
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-(trifluoromethyl)phenyl)urea
Show/Hide
|
C21H17F3N8O2
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0475658
|
(2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-phenylpropanoic acid
Show/Hide
|
C32H38N8O7
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0211418
|
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclobutyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C14H18N6O4
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0536292
|
US9029393, 107
Show/Hide
|
C28H26FN5O
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0563901
|
US9029393, 24
Show/Hide
|
C23H23ClFN3O2
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0255142
|
9-Benzyl-6-furan-2-yl-9H-purin-2-ylamine
Show/Hide
|
C16H13N5O
|
1
|
| 1 |
Ki = 34.9 nM
|
|
|
|
CP0524114
|
3-cyano-N-(6-(piperidine-1-carbonyl)-3-(pyridin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C26H23N7O2
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0461179
|
N-(5-cyano-4,6-diphenylpyrimidin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H18N4O
|
1
|
| 1 |
Ki = 35.3 nM
|
|
|
|
CP0509955
|
N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylphenoxy)acetamide
Show/Hide
|
C21H18N4O3S
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0510216
|
5-(2-cyclopropylpyridin-4-yl)-4-phenylpyrimidin-2-amine
Show/Hide
|
C18H16N4
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0378476
|
8-[1-[[2-oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H28F3N7O4
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0454514
|
N-[3-(2-acetamidoethyl)-6-(piperidine-1-carbonyl)imidazo[4,5-b]pyridin-2-yl]-3-cyanobenzamide
Show/Hide
|
C24H25N7O3
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0448140
|
N-[4-(furan-2-yl)-11-(3-methylbutyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenoxyacetamide
Show/Hide
|
C23H23N7O3
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0395760
|
tert-butyl N-[3-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]propyl]carbamate
Show/Hide
|
C16H22N8O3
|
1
|
| 1 |
Ki = 38.6 nM
|
|
|
|
CP0395301
|
4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzamide
Show/Hide
|
C26H28N6O5
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0404077
|
4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzoic acid (0.60CH2CL2)
Show/Hide
|
C26H27N5O6
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0392155
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-(4-chlorophenyl)ethanone
Show/Hide
|
C20H19ClN8O2
|
1
|
| 1 |
Ki = 39.1 nM
|
|
|
|
CP0258307
|
1-(4-Bromo-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H15BrN8O2
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0348520
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenyl-urea
Show/Hide
|
C19H16N8O2
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0514732
|
2-(5-chlorofuran-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethoxy)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C24H28ClN7O4
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0474617
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(pyridin-2-yloxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0397573
|
N-[4-(furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenoxyacetamide
Show/Hide
|
C26H21N7O3
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0501881
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(pyridin-4-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C16H16N6O
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0526303
|
N-butyl-2-[(3-cyanobenzoyl)amino]-3-(3-methoxypropyl)imidazo[4,5-b]pyridine-6-carboxamide
Show/Hide
|
C23H26N6O3
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0431162
|
(2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-(1H-imidazol-5-yl)propanoic acid
Show/Hide
|
C29H36N10O7
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0395523
|
tert-butyl N-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]carbamate
Show/Hide
|
C15H20N8O3
|
1
|
| 1 |
Ki = 40.9 nM
|
|
|
|
CP0373873
|
2-Amino-4-(4-hydroxy-phenyl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C16H11N3O2
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0495903
|
2-Amino-4-(4-methoxy-phenyl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C17H13N3O2
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0047377
|
1-(4-Fluoro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17FN8O2
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0853216
|
3-[3-(2-furan-2-yl-8-methy-8H-pyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl)-ureido]-N-methylpyridinium iodide
Show/Hide
|
C18H16IN9O2
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0453144
|
N-[4-(furan-2-yl)-11-(3-methylbutyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
Show/Hide
|
C27H25N7O2
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0387266
|
N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-(3-methoxyphenoxy)-2-methylpropanamide
Show/Hide
|
C22H26N4O5S
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0517820
|
2-(1,3-benzodioxol-5-yloxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C22H24N4O6S
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0494651
|
1-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxymethylpyrrolidin-1-yl)pyrimidin-4-yl]-3-isopropylurea
Show/Hide
|
C19H29N7O2
|
1
|
| 1 |
Ki = 43 nM
|
|
|
|
CP0474661
|
(4-(furan-2-yl)-2-(furan-2-ylmethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C19H14N2O3S
|
1
|
| 1 |
Ki = 43 nM
|
|
|
|
CP0476881
|
2-(4-amino-6-phenyl-1,3,5-triazin-2-yl)phenol
Show/Hide
|
C15H12N4O
|
1
|
| 1 |
Ki = 43 nM
|
|
|
|
CP0221420
|
2-(3,5-dimethylpyrazol-1-yl)-N-pyrazin-2-yl-6-pyrazol-1-ylpyrimidin-4-amine
Show/Hide
|
C16H15N9
|
1
|
| 1 |
Ki = 43 nM
|
|
|
|
CP0374953
|
7-(3-(4-ethoxyphenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C21H21N7O2
|
1
|
| 1 |
Ki = 43.9 nM
|
|
|
|
CP0388101
|
N-[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]benzamide
Show/Hide
|
C15H11N7O2
|
1
|
| 1 |
Ki = 44.1 nM
|
|
|
|
CP0458057
|
4-amino-6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidine-5-carbonitrile
Show/Hide
|
C18H12N4O2
|
1
|
| 1 |
Ki = 44.3 nM
|
|
|
|
CP0431136
|
tert-butyl N-[5-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]pentyl]carbamate
Show/Hide
|
C18H26N8O3
|
1
|
| 1 |
Ki = 44.7 nM
|
|
|
|
CP0377526
|
N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenoxyacetamide
Show/Hide
|
C27H23N7O3
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0379022
|
(2R,3R,4S)-2-(2-chloro-6-(methylamino)-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol
Show/Hide
|
C10H12ClN5O2S
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0123209
|
2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-N-pyridin-2-ylpyrimidin-4-amine
Show/Hide
|
C20H25N7O
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0392536
|
2-amino-N-(cyclohexylmethyl)-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C16H19FN4O
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0412864
|
N-(5-cyano-4,6-diphenylpyrimidin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C21H16N4O
|
1
|
| 1 |
Ki = 45.5 nM
|
|
|
|
CP0469281
|
2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)ethyl methanesulfonate
Show/Hide
|
C22H23N7O5S
|
1
|
| 1 |
Ki = 45.7 nM
|
|
|
|
CP0522732
|
2-(furan-2-yl)-N7-(4-methoxybenzyl)-N7-methyl-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Show/Hide
|
C18H18N6O2
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0445402
|
N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-pyridin-2-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C17H21N5O2
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0521990
|
2-(3-cyanobenzamido)-N-(3-methoxybenzyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxamide
Show/Hide
|
C28H27N5O4
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0485897
|
9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C8H8N8
|
1
|
| 1 |
Ki = 46.3 nM
|
|
|
|
CP0445404
|
N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-thiophen-2-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C16H20N4O2S
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0491372
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(methoxymethyl)-5-methylpyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C18H26N6O2
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0523784
|
3-cyano-N-(1-(3-methoxypropyl)-5-(piperidine-1-carbonyl)-1H-benzo[d]imidazol-2-yl)benzamide
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0526302
|
N-butyl-2-[(3-cyanobenzoyl)amino]-1-(3-methoxypropyl)benzimidazole-5-carboxamide
Show/Hide
|
C24H27N5O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0403353
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenol
Show/Hide
|
C19H17N7O2
|
2
|
| 1 |
Ki = 48 nM
|
|
|
| 2 |
Ki = 48.3 nM
|
|
|
|
CP0464383
|
N-(5-cyano-4,6-diphenylpyrimidin-2-yl)butanamide
Show/Hide
|
C21H18N4O
|
1
|
| 1 |
Ki = 48.2 nM
|
|
|
|
CP0288431
|
5-Butyl-8-(4-propoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C19H22N6O
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0311179
|
4-(5-butyl-1H-[1,2,4]triazolo[5,1-f]purin-8-yl)-N,N-dimethylaniline
Show/Hide
|
C18H21N7
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0526986
|
8-(1-(2-chlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23ClN6O2
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0461251
|
N-(5-cyano-2,6-diphenylpyrimidin-4-yl)cyclopropanecarboxamide
Show/Hide
|
C21H16N4O
|
1
|
| 1 |
Ki = 49.8 nM
|
|
|
|
CP0430162
|
2-(4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)phenylsulfonamido)acetic acid
Show/Hide
|
C20H18N8O5S
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0187298
|
1-(4-Bromo-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17BrN8O2
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0290657
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-fluoro-phenyl)-urea
Show/Hide
|
C21H19FN8O2
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0474618
|
N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-pyridin-2-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C17H21N5O2
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0474620
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]-3-methylbutanamide
Show/Hide
|
C20H30N6O2
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0529814
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-4-ylmethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H20F2N6O2
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0431165
|
(2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-5-(diaminomethylideneamino)pentanoic acid
Show/Hide
|
C29H41N11O7
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0039632
|
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C13H16N6O4
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0848683
|
6-ethyl-7-hydroxy-3-(2-methylthiazol-4-yl)-4H-chromen-4-one
Show/Hide
|
C15H13NO3S
|
1
|
| 1 |
Ki = 50.12 nM
|
|
|
|
CP0433180
|
N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C19H22N6O2S
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0461927
|
8-(1-(2-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0475504
|
3-cyano-N-(3-(3-hydroxypropyl)-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C23H24N6O3
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0477673
|
2-(4-chlorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H24ClN3O4S
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0234383
|
6-(3-chlorophenyl)-5-phenyl-1,2,4-triazin-3-amine
Show/Hide
|
C15H11ClN4
|
1
|
| 1 |
Ki = 51.29 nM
|
|
|
|
CP0904920
|
3-(4-{2-[6-Amino-9-((2R,3R,4S,5S)-5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid hydrochloride
Show/Hide
|
C23H30ClN7O6
|
1
|
| 1 |
Ki = 51.3 nM
|
|
|
|
CP0490695
|
1-Methyl-2-[1,2,3]triazol-2-yl-1H-imidazo[4,5-c]pyridin-4-ylamine
Show/Hide
|
C9H9N7
|
1
|
| 1 |
Ki = 51.6 nM
|
|
|
|
CP0395525
|
5-[4-(3-Chloro-benzyl)-piperazin-1-yl]-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine
Show/Hide
|
C19H19ClN8O
|
1
|
| 1 |
Ki = 51.8 nM
|
|
|
|
CP0485486
|
2-Hydroxymethyl-5-[6-(3-iodo-benzylamino)-2-(4-isoquinolin-1-yl-pyrazol-1-yl)-purin-9-yl]-tetrahydro-furan-3,4-diol
Show/Hide
|
C29H25IN8O4
|
1
|
| 1 |
Ki = 52 nM
|
|
|
|
CP0221296
|
2-(3,5-dimethylpyrazol-1-yl)-6-pyrazol-1-yl-N-(2,2,2-trifluoroethyl)pyrimidin-4-amine
Show/Hide
|
C14H14F3N7
|
1
|
| 1 |
Ki = 52 nM
|
|
|
|
CP0427802
|
5-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
Show/Hide
|
C19H19FN8O
|
1
|
| 1 |
Ki = 52.3 nM
|
|
|
|
CP0187299
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-trifluoromethyl-phenyl)-urea
Show/Hide
|
C20H15F3N8O2
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0420523
|
2,6-diphenyl-9H-purine
Show/Hide
|
C17H12N4
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0406628
|
8-[6-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]pyridin-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C28H29F3N6O4
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0405086
|
2-(4-methylpiperazin-1-yl)-N-[6-(1H-pyrazol-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C19H22N8O
|
1
|
| 1 |
Ki = 53.4 nM
|
|
|
|
CP0422858
|
7-(3-(4-(3-Fluoropropoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C22H22FN7O2
|
1
|
| 1 |
Ki = 53.6 nM
|
|
|
|
CP0522424
|
7-benzyl-2-(cyclopropylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0505747
|
(4-(furan-2-yl)-2-(thiophen-2-ylmethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C19H14N2O2S2
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0400898
|
2-Amino-6-phenyl-4-thiophen-2-yl-nicotinonitrile
Show/Hide
|
C16H11N3S
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0455032
|
N-(5-cyano-4,6-diphenylpyrimidin-2-yl)-2-ethylbutanamide
Show/Hide
|
C23H22N4O
|
1
|
| 1 |
Ki = 54.5 nM
|
|
|
|
CP0443842
|
4-[(E)-(4-chlorophenyl)methylideneamino]-3-propyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C14H12ClN3S2
|
1
|
| 1 |
Ki = 54.8 nM
|
|
|
|
CP0468028
|
7-(4-aminophenethyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C18H16N8O
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0454450
|
N-[4-(furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
Show/Hide
|
C30H23N7O2
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0451651
|
8-cyclopentyl-2,6-diphenyl-9H-purine
Show/Hide
|
C22H20N4
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0513772
|
N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methyl-2-(4-methylphenoxy)propanamide
Show/Hide
|
C22H26N4O4S
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0018686
|
(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide
Show/Hide
|
C18H19IN6O4
|
6
|
| 1 |
Ki = 56 nM
|
|
|
| 2 |
Ki = 93.1 nM
|
|
|
| 3 |
Ki = 510 nM
|
|
|
| 4 |
Ki = 2900 nM
|
|
|
| 5 |
Ki = 2910 nM
|
|
|
| 6 |
Ki = 6200 nM
|
|
|
|
CP0392343
|
N-[4-(furan-2-yl)-11-(3-methylbutyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C23H23N7O2
|
1
|
| 1 |
Ki = 57 nM
|
|
|
|
CP0406633
|
8-[1-[2-oxo-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H31F3N8O3
|
1
|
| 1 |
Ki = 57 nM
|
|
|
|
CP0081315
|
9-(5'-Ethylaminocarbonyl-4-thio-beta-D-ribofuranosyl)-N6-(3-iodo-benzyl)adenine
Show/Hide
|
C19H21IN6O3S
|
1
|
| 1 |
Ki = 57.6 nM
|
|
|
|
CP0388348
|
2-Amino-6-phenyl-4-(3-trifluoromethoxy-phenyl)-nicotinonitrile
Show/Hide
|
C19H12F3N3O
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0451696
|
2-(4-cyanophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C23H24N4O4S
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0439986
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-dimethylpropan-1-one
Show/Hide
|
C17H22N8O2
|
1
|
| 1 |
Ki = 58.4 nM
|
|
|
|
CP0445937
|
N-[5-(2,2-difluoro-4,6,10,12-tetramethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)pentyl]-2-[4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)phenoxy]acetamide
Show/Hide
|
C34H40BF2N7O4
|
1
|
| 1 |
Ki = 58.7 nM
|
|
|
|
CP0448990
|
N-(3-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 58.9 nM
|
|
|
|
CP0422125
|
5-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-2-carboxylic acid
Show/Hide
|
C21H17N7O5
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0427799
|
2-(furan-2-yl)-5-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
Show/Hide
|
C12H13N7O
|
1
|
| 1 |
Ki = 59.1 nM
|
|
|
|
CP0376071
|
(2S,3S,4R,5R)-5-(2-((R,S)-3-cyclohexyl-3-hydroxyprop-1-ynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H32N6O5
|
1
|
| 1 |
Ki = 59.3 nM
|
|
|
|
CP0210713
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-fluoro-phenyl)-urea
Show/Hide
|
C19H15FN8O2
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0475229
|
5-[[(benzofuran-2-yl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C20H14N8O3
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0395252
|
N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C27H23N7O2
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0431005
|
N-[4-(furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C26H21N7O2
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0378791
|
8-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23FN6O2
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0522422
|
7-(2,6-difluorobenzyl)-2-(isopropylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21F2N5O2
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0378800
|
8-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O3
|
1
|
| 1 |
Ki = 61 nM
|
|
|
|
CP0387915
|
(2-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C23H18N2O4S
|
1
|
| 1 |
Ki = 61 nM
|
|
|
|
CP0482303
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-(trifluoromethyl)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C18H18F3N7O4
|
1
|
| 1 |
Ki = 61 nM
|
|
|
|
CP0333052
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenylurea
Show/Hide
|
C20H18N8O2
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0391375
|
(2R,3R,4R)-2-(6-amino-2-hex-1-ynylpurin-9-yl)oxolane-3,4-diol
Show/Hide
|
C15H19N5O3
|
1
|
| 1 |
Ki = 63.2 nM
|
|
|
|
CP0431160
|
(2S)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-phenylpropanoic acid
Show/Hide
|
C32H38N8O7
|
1
|
| 1 |
Ki = 63.7 nM
|
|
|
|
CP0849513
|
2-[3-(2-furan-2-yl-8-methy-8H-pyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl)-ureido]-N-methylpyridinium iodide
Show/Hide
|
C18H16IN9O2
|
1
|
| 1 |
Ki = 64 nM
|
|
|
|
CP0474662
|
(2-(3,4-difluorobenzylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C21H14F2N2O2S
|
1
|
| 1 |
Ki = 64 nM
|
|
|
|
CP0550930
|
1-[6-amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-ol
Show/Hide
|
C12H16N8O
|
1
|
| 1 |
Ki = 64 nM
|
|
|
|
CP0376341
|
1-(2-Furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-pyridin-4-yl-urea
Show/Hide
|
C17H13N9O2
|
1
|
| 1 |
Ki = 65 nM
|
|
|
|
CP0108312
|
6-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(3,5-dimethylpyrazol-1-yl)-N-pyridin-2-ylpyrimidin-4-amine
Show/Hide
|
C23H23N7
|
1
|
| 1 |
Ki = 65 nM
|
|
|
|
CP0446696
|
4-[[5-(2-cyclopropylpyridin-4-yl)-4-phenylpyrimidin-2-yl]amino]cyclohexan-1-ol
Show/Hide
|
C24H26N4O
|
1
|
| 1 |
Ki = 65 nM
|
|
|
|
CP0143977
|
1-(4-Bromo-phenyl)-3-(8-butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C21H19BrN8O2
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0451652
|
2,6,8-triphenyl-9H-purine
Show/Hide
|
C23H16N4
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0464324
|
8-(1-(3-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0541941
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-3-ylmethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H20F2N6O2
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0175608
|
N-[6-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]-1,3-thiazol-2-amine
Show/Hide
|
C21H21N7S
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0392824
|
methyl 4-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-4-oxobutanoate
Show/Hide
|
C17H20N8O4
|
1
|
| 1 |
Ki = 66.2 nM
|
|
|
|
CP0501802
|
(R)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-((1-methylpyrrolidin-3-yloxy)methyl)phenyl)pyrimidin-4-yl)acetamide
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 67 nM
|
|
|
|
CP0387916
|
(4-(furan-2-yl)-2-(methylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C15H12N2O2S
|
1
|
| 1 |
Ki = 67 nM
|
|
|
|
CP0455806
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-(N-phenylanilino)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C29H28N8O4
|
1
|
| 1 |
Ki = 67 nM
|
|
|
|
CP0461563
|
6-Furan-2-yl-9-phenyl-9H-purin-2-ylamine
Show/Hide
|
C15H11N5O
|
1
|
| 1 |
Ki = 68.5 nM
|
|
|
|
CP0244328
|
2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-N-pyrazin-2-ylpyrimidin-4-amine
Show/Hide
|
C19H24N8O
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0511411
|
N-[6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-yl]cyclopropanecarboxamide
Show/Hide
|
C21H17N3O3
|
1
|
| 1 |
Ki = 69.2 nM
|
|
|
|
CP0394321
|
N-(5-cyano-2,6-diphenylpyrimidin-4-yl)butanamide
Show/Hide
|
C21H18N4O
|
1
|
| 1 |
Ki = 69.5 nM
|
|
|
|
CP0393643
|
tert-butyl N-[[4-[[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]methyl]cyclohexyl]methyl]carbamate
Show/Hide
|
C21H30N8O3
|
1
|
| 1 |
Ki = 69.7 nM
|
|
|
|
CP0453330
|
2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-(4-nitro-phenyl)-acetamide (0.43CH3OH)
Show/Hide
|
C25H26N6O6
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0464321
|
8-(1-(2,5-dichlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1Hpurine-2,6(3H,7H)-dione
Show/Hide
|
C21H22Cl2N6O2
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0464323
|
8-(1-(3-methoxybenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O3
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0375991
|
2,9-Dimethyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C9H10N8
|
1
|
| 1 |
Ki = 70.4 nM
|
|
|
|
CP0466523
|
8-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C22H28N4O4
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0537946
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(1,3-thiazol-5-ylmethylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C14H16N8O4S
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0467188
|
(2S)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-(1H-indol-3-yl)propanoic acid
Show/Hide
|
C34H39N9O7
|
1
|
| 1 |
Ki = 71.7 nM
|
|
|
|
CP0541942
|
2-(benzylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C26H21F2N5O2
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0474416
|
(2R,3R,4S)-2-(6-amino-2-((E)-hex-1-enyl)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol
Show/Hide
|
C15H21N5O2S
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0563085
|
US9029393, 132
Show/Hide
|
C20H19FN6O
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0373086
|
8-(1-benzylpyrazol-4-yl)-1-ethyl-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C18H18N6O2
|
1
|
| 1 |
Ki = 73 nM
|
|
|
|
CP0394506
|
1-(cyclopropylmethyl)-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C20H19FN6O2
|
1
|
| 1 |
Ki = 73 nM
|
|
|
|
CP0386251
|
(S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-((1-methylpyrrolidin-3-yloxy)methyl)phenyl)pyrimidin-4-yl)acetamide
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 73 nM
|
|
|
|
CP0198681
|
2-amino-N-[(4-ethoxyquinolin-8-yl)methyl]-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C21H18FN5O2
|
1
|
| 1 |
Ki = 73.2 nM
|
|
|
|
CP0497710
|
6-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-5-sulfonic acid
Show/Hide
|
C20H17N7O6S
|
1
|
| 1 |
Ki = 75 nM
|
|
|
|
CP0382463
|
3-[3-(2-furan-2-yl-8-methy-8H-pyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl)-ureido]pyridinium N-oxide
Show/Hide
|
C17H13N9O3
|
1
|
| 1 |
Ki = 75 nM
|
|
|
|
CP0459174
|
N-[2-[[2-[4-[3-[7-amino-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-10-yl]propyl]phenoxy]acetyl]amino]ethyl]hept-6-ynamide
Show/Hide
|
C30H33N9O4
|
1
|
| 1 |
Ki = 75.4 nM
|
|
|
|
CP0474814
|
2-(cyclopropylamino)-9-(3,5-dimethoxyphenyl)-7-(2-methoxybenzyl)-7H-purin-8(9H)-one
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
Ki = 76 nM
|
|
|
|
CP0387269
|
N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methyl-2-[4-(trifluoromethyl)phenoxy]propanamide
Show/Hide
|
C23H24F3N3O4S
|
1
|
| 1 |
Ki = 76 nM
|
|
|
|
CP0474619
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-piperidin-1-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C16H22N6O
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0514723
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(2-(pyridin-2-yl)ethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C26H22F2N6O2
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0425758
|
2-(furan-2-yl)-7-(3-(4-(3-phenylpropoxy)phenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C27H25N7O2
|
1
|
| 1 |
Ki = 78.9 nM
|
|
|
|
CP0455088
|
8-(1-(3-chlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23ClN6O2
|
1
|
| 1 |
Ki = 79 nM
|
|
|
|
CP0880305
|
7-(cyclopropylmethoxy)-5-methyl-3-(4-methylthiazol-2-yl)-4H-chromen-4-one
Show/Hide
|
C18H17NO3S
|
1
|
| 1 |
Ki = 79.43 nM
|
|
|
|
CP0957848
|
6-ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one
Show/Hide
|
C15H13NO3S
|
1
|
| 1 |
Ki = 79.43 nM
|
|
|
|
CP0220980
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea
Show/Hide
|
C22H22N8O3
|
1
|
| 1 |
Ki = 80 nM
|
|
|
|
CP0453784
|
8-(1-(4-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 80 nM
|
|
|
|
CP0054094
|
Binodenoson
Show/Hide
|
C17H25N7O4
|
2
|
| 1 |
Ki = 81 nM
|
|
|
| 2 |
Ki = 270 nM
|
|
|
|
CP0395969
|
N-(2,6-diphenylpyrimidin-4-yl)propanamide
Show/Hide
|
C19H17N3O
|
1
|
| 1 |
Ki = 81.9 nM
|
|
|
|
CP0466884
|
9-Methyl-2-propyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C11H14N8
|
1
|
| 1 |
Ki = 83.7 nM
|
|
|
|
CP0514626
|
US9029393, 136
Show/Hide
|
C22H21FN6O
|
1
|
| 1 |
Ki = 84 nM
|
|
|
|
CP0431159
|
methyl (2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-phenylpropanoate
Show/Hide
|
C33H40N8O7
|
1
|
| 1 |
Ki = 84.3 nM
|
|
|
|
CP0376218
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzonitrile
Show/Hide
|
C20H16N8O
|
1
|
| 1 |
Ki = 86 nM
|
|
|
|
CP0471160
|
N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-(propan-2-yloxy)pyrrolidin-1-yl]acetamide
Show/Hide
|
C23H30N6O3
|
1
|
| 1 |
Ki = 86 nM
|
|
|
|
CP0502582
|
7-(2-chlorobenzyl)-2-(cyclopropylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H20ClN5O2
|
1
|
| 1 |
Ki = 86 nM
|
|
|
|
CP0146188
|
2-amino-8-methylsulfonyl-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C20H17N5O3S
|
1
|
| 1 |
Ki = 86 nM
|
|
|
|
CP0395526
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-(4-bromophenyl)ethanone
Show/Hide
|
C20H19BrN8O2
|
1
|
| 1 |
Ki = 86.2 nM
|
|
|
|
CP0439354
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-phenylpyrimidin-4-yl]acetamide
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
Ki = 87 nM
|
|
|
|
CP0529515
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[4-(morpholin-4-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
Ki = 87 nM
|
|
|
|
CP0448575
|
methyl (2S)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-(1H-indol-3-yl)propanoate
Show/Hide
|
C35H41N9O7
|
1
|
| 1 |
Ki = 87.2 nM
|
|
|
|
CP0378799
|
8-(1-(4-chlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23ClN6O2
|
1
|
| 1 |
Ki = 88 nM
|
|
|
|
CP0400196
|
(2-(benzyl(furan-2-ylmethyl)amino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C26H20N2O3S
|
1
|
| 1 |
Ki = 88 nM
|
|
|
|
CP0400896
|
2-Amino-4-phenyl-6-thiophen-2-yl-nicotinonitrile
Show/Hide
|
C16H11N3S
|
1
|
| 1 |
Ki = 88 nM
|
|
|
|
CP0522817
|
2-(cyclopropylamino)-9-(3-fluorophenyl)-7-(2-methoxybenzyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H20FN5O2
|
1
|
| 1 |
Ki = 89 nM
|
|
|
|
CP0507788
|
(4-(furan-2-yl)-2-(isobutylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C18H18N2O2S
|
1
|
| 1 |
Ki = 89 nM
|
|
|
|
CP0880294
|
5-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)pentan-1-aminium 2,2,2-trifluoroacetate
Show/Hide
|
C15H19F3N8O3
|
1
|
| 1 |
Ki = 90.1 nM
|
|
|
|
CP0133191
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxy-phenyl)-urea
Show/Hide
|
C22H22N8O3
|
1
|
| 1 |
Ki = 91 nM
|
|
|
|
CP0374549
|
N-[6-(diethylamino)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C15H22N6O
|
1
|
| 1 |
Ki = 92 nM
|
|
|
|
CP0381648
|
2-Amino-4-(3,4-dimethoxy-phenyl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C18H15N3O3
|
1
|
| 1 |
Ki = 92 nM
|
|
|
|
CP0528635
|
3-cyano-N-(3-(3-methoxypropyl)-6-(morpholine-4-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C23H24N6O4
|
1
|
| 1 |
Ki = 92 nM
|
|
|
|
CP0395529
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-diphenylethanone
Show/Hide
|
C26H24N8O2
|
1
|
| 1 |
Ki = 92.9 nM
|
|
|
|
CP0121162
|
6-[(E)-2-(4-acetylphenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C19H19N3O3
|
1
|
| 1 |
Ki = 93.9 nM
|
|
|
|
CP0388116
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-phenylethanone
Show/Hide
|
C20H20N8O2
|
1
|
| 1 |
Ki = 94.8 nM
|
|
|
|
CP0092135
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-chloro-phenyl)-urea
Show/Hide
|
C21H19ClN8O2
|
1
|
| 1 |
Ki = 95 nM
|
|
|
|
CP0187296
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxy-phenyl)-urea
Show/Hide
|
C22H22N8O3
|
1
|
| 1 |
Ki = 95 nM
|
|
|
|
CP0437988
|
methyl 2-[4-[3-[7-amino-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-10-yl]propyl]phenoxy]acetate
Show/Hide
|
C22H21N7O4
|
1
|
| 1 |
Ki = 96 nM
|
|
|
|
CP0446695
|
4-phenyl-5-[3-(trifluoromethyl)phenyl]pyrimidin-2-amine
Show/Hide
|
C17H12F3N3
|
1
|
| 1 |
Ki = 98 nM
|
|
|
|
CP0462060
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)benzenesulfonic acid
Show/Hide
|
C18H15N7O4S
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0047382
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxyphenyl)urea
Show/Hide
|
C21H20N8O3
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0053427
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-chloro-phenyl)-urea
Show/Hide
|
C21H19ClN8O2
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0116392
|
1-(4-Bromo-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13BrN8O2
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0500972
|
8-[3-(2-Diethylaminoethoxy)phenyl]-1,3-dimethylxanthine
Show/Hide
|
C19H25N5O3
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0542913
|
1,3-Dimethyl-8-[4-methoxy-3-(2-morpholin-4-ylethoxy)-phenylxanthine
Show/Hide
|
C20H25N5O5
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0457870
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H17FN6O2
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0448576
|
(2S)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-5-(diaminomethylideneamino)pentanoic acid
Show/Hide
|
C29H41N11O7
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0395293
|
(1R,2R,3S,4R,5S)-4-(6-amino-2-hex-1-ynylpurin-9-yl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C17H21N5O2
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0887481
|
ethyl 2-(5-methyl-3-(4-methylthiazol-2-yl)-4-oxo-4H-chromen-7-yloxy)acetate
Show/Hide
|
C18H17NO5S
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0537945
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3-methoxy-4-phenylmethoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C25H27N7O6
|
1
|
| 1 |
Ki = 101 nM
|
|
|
|
CP0431083
|
5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine
Show/Hide
|
C19H19ClN8O
|
1
|
| 1 |
Ki = 102 nM
|
|
|
|
CP0563084
|
US9029393, 30
Show/Hide
|
C21H21FN4O2
|
1
|
| 1 |
Ki = 103 nM
|
|
|
|
CP0444120
|
2-Amino-6-(1H-imidazol-2-ylmethylsulfanyl)-4-(3-methoxy-phenyl)-pyridine-3,5-dicarbonitrile
Show/Hide
|
C18H14N6OS
|
1
|
| 1 |
Ki = 105 nM
|
|
|
|
CP0474663
|
(2-(1-(2-fluorobenzyl)piperidin-4-ylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C26H24FN3O2S
|
1
|
| 1 |
Ki = 105 nM
|
|
|
|
CP0515271
|
(4-(furan-2-yl)-2-(3-phenylpropylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C23H20N2O2S
|
1
|
| 1 |
Ki = 105 nM
|
|
|
|
CP0474811
|
7-(2,6-difluorobenzyl)-2-(2-methoxyethylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21F2N5O3
|
1
|
| 1 |
Ki = 106 nM
|
|
|
|
CP0466969
|
US9029393, 10
Show/Hide
|
C23H24BrN3O2
|
1
|
| 1 |
Ki = 108 nM
|
|
|
|
CP0517426
|
4-phenyl-5-pyridin-4-ylpyrimidin-2-amine
Show/Hide
|
C15H12N4
|
1
|
| 1 |
Ki = 108 nM
|
|
|
|
CP0333181
|
1-(3-Chloro-phenyl)-3-(2-furan-2-yl-8-phenethyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C25H19ClN8O2
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0333051
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolylurea
Show/Hide
|
C19H16N8O2
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0382462
|
2-[3-(2-furan-2-yl-8-methy-8H-pyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl)-ureido]pyridinium N-oxide
Show/Hide
|
C17H13N9O3
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0849514
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(pyridin-4-yl)urea hydrochloride
Show/Hide
|
C17H14ClN9O2
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0474624
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-pyrrolidin-1-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C15H20N6O
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0392915
|
(2S)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-(1H-imidazol-5-yl)propanoic acid
Show/Hide
|
C29H36N10O7
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0513474
|
(2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]butanedioic acid
Show/Hide
|
C27H34N8O9
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0079507
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-chloro-phenyl)-urea
Show/Hide
|
C21H19ClN8O2
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0502581
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(pyridin-3-ylamino)-7H-purin-8(9H)-one
Show/Hide
|
C24H18F2N6O2
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0917065
|
triethylammonium 5-(2-(2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetamido)ethylcarbamoyl)-2-(6-amino-3-iminio-4,5-disulfonato-3H-xanthen-9-yl)benzoate
Show/Hide
|
C56H67N13O13S2
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0308003
|
N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 112 nM
|
|
|
|
CP0237635
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxyphenyl)urea
Show/Hide
|
C21H20N8O3
|
1
|
| 1 |
Ki = 113 nM
|
|
|
|
CP0390404
|
2-(3,4-dimethoxyphenyl)-6-(furan-2-yl)imidazo[1,2-a]pyridin-8-amine
Show/Hide
|
C19H17N3O3
|
1
|
| 1 |
Ki = 117 nM
|
|
|
|
CP0054099
|
5,6-diphenyl-1,2,4-triazin-3-amine
Show/Hide
|
C15H12N4
|
1
|
| 1 |
Ki = 117.49 nM
|
|
|
|
CP0318841
|
8-cyclohexyl-2,6-diphenyl-9H-purine
Show/Hide
|
C23H22N4
|
1
|
| 1 |
Ki = 118 nM
|
|
|
|
CP0474621
|
N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C17H22N4O3
|
1
|
| 1 |
Ki = 119 nM
|
|
|
|
CP0376596
|
5-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzo[d][1,3]dioxole-2,2-dicarboxylic acid
Show/Hide
|
C22H17N7O7
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0847207
|
disodium 5-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-2,2-dicarboxylic acid
Show/Hide
|
C22H15N7Na2O7
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0133195
|
1-(4-Fluoro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13FN8O2
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0483654
|
1,6-Dimethyl-2-[1,2,3]triazol-2-yl-1H-imidazo[4,5-c]pyridin-4-ylamine
Show/Hide
|
C10H11N7
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0455086
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0456959
|
8-(1-(4-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23FN6O2
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0439355
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(pyridin-3-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C16H16N6O
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0446708
|
5-(3-chlorophenyl)-4-phenylpyrimidin-2-amine
Show/Hide
|
C16H12ClN3
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0333031
|
1-(2-Chloro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17ClN8O2
|
1
|
| 1 |
Ki = 121 nM
|
|
|
|
CP0259712
|
N-[4-(3,5-dimethylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
|
C22H18N4OS
|
1
|
| 1 |
Ki = 121 nM
|
|
|
|
CP0231424
|
9-(5'-Cyclobutylaminocarbonyl-4'-thio-beta-D-ribofuranosyl)-N6-(3-iodobenzyl)adenine
Show/Hide
|
C21H23IN6O3S
|
1
|
| 1 |
Ki = 122 nM
|
|
|
|
CP0468973
|
2-(3-cyanobenzamido)-3-(3-methoxypropyl)-N,N-dimethyl-3H-imidazo[4,5-b]pyridine-6-carboxamide
Show/Hide
|
C21H22N6O3
|
1
|
| 1 |
Ki = 123 nM
|
|
|
|
CP0045165
|
1-(2-(furan-2-yl)-8-phenethyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea
Show/Hide
|
C26H22N8O3
|
1
|
| 1 |
Ki = 124 nM
|
|
|
|
CP0395859
|
N-(2,6-diphenylpyrimidin-4-yl)butanamide
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
Ki = 124 nM
|
|
|
|
CP0427800
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]pentan-1-one
Show/Hide
|
C17H22N8O2
|
1
|
| 1 |
Ki = 124 nM
|
|
|
|
CP0397979
|
8-[1-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H28F3N7O3
|
1
|
| 1 |
Ki = 124 nM
|
|
|
|
CP0390571
|
5-[[(3-pyridyl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H13N9O2
|
1
|
| 1 |
Ki = 125 nM
|
|
|
|
CP0407892
|
8-(1-benzylpyrazol-4-yl)-3-methyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki = 125 nM
|
|
|
|
CP0424857
|
2-amino-8-fluoro-N-[(1S)-1-quinolin-8-ylethyl]quinazoline-4-carboxamide
Show/Hide
|
C20H16FN5O
|
1
|
| 1 |
Ki = 126 nM
|
|
|
|
CP0435534
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-phenylprop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H26N6O5
|
1
|
| 1 |
Ki = 129 nM
|
|
|
|
CP0446698
|
5-naphthalen-2-yl-4-phenylpyrimidin-2-amine
Show/Hide
|
C20H15N3
|
1
|
| 1 |
Ki = 129 nM
|
|
|
|
CP0381652
|
2-Amino-4,6-diphenyl-nicotinonitrile
Show/Hide
|
C18H13N3
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0400889
|
2-Amino-4-[3-(methyl)phenyl]-6-phenyl-3-pyridinecarbonitrile
Show/Hide
|
C19H15N3
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0431161
|
methyl (2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-(1H-indol-3-yl)propanoate
Show/Hide
|
C35H41N9O7
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0431163
|
(2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-(1H-indol-3-yl)propanoic acid
Show/Hide
|
C34H39N9O7
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0433198
|
N-[2,6-bis(1H-pyrazol-1-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C17H21N9O
|
1
|
| 1 |
Ki = 131 nM
|
|
|
|
CP0424774
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carboxylic Acid (2-dimethylamino-ethyl)-amide
Show/Hide
|
C24H38N6O3
|
1
|
| 1 |
Ki = 132 nM
|
|
|
|
CP0237628
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxy-phenyl)-urea
Show/Hide
|
C20H18N8O3
|
1
|
| 1 |
Ki = 133 nM
|
|
|
|
CP0505123
|
N-[2-(5-methylfuran-2-yl)-6-(1H-pyrazol-1-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C19H23N7O2
|
1
|
| 1 |
Ki = 135 nM
|
|
|
|
CP0512021
|
US9029393, 48
Show/Hide
|
C27H31N3O2
|
1
|
| 1 |
Ki = 138 nM
|
|
|
|
CP0373148
|
8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C19H19FN6O2
|
1
|
| 1 |
Ki = 139 nM
|
|
|
|
CP0392763
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzenesulfonic acid
Show/Hide
|
C19H17N7O4S
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0053428
|
1-[4-(furan-2-yl)-11-propyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-3-(4-methoxyphenyl)urea
Show/Hide
|
C21H20N8O3
|
2
|
| 1 |
Ki = 140 nM
|
|
|
| 2 |
Ki = 141 nM
|
|
|
|
CP0237626
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-(trifluoromethyl)phenyl)urea
Show/Hide
|
C19H13F3N8O2
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0248930
|
1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17ClN8O2
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0291712
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxy-phenyl)-urea
Show/Hide
|
C20H18N8O3
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0390573
|
5-[[(2-pyridyl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H13N9O2
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0455089
|
8-(1-(2-methoxybenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O3
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0381654
|
2-Amino-4-(4-chloro-phenyl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C16H10ClN3O
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0400895
|
2-Amino-4-(3-methyl-phenyl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C17H13N3O
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0085632
|
(E)-8-(4-Chlorostyryl)caffeine (4a)
Show/Hide
|
C16H15ClN4O2
|
1
|
| 1 |
Ki = 140.8 nM
|
|
|
|
CP0047372
|
1-(3,4-Dichloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H12Cl2N8O2
|
1
|
| 1 |
Ki = 143 nM
|
|
|
|
CP0432710
|
(R,S)-methyl 3-(3-(6-(ethylamino)-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1-hydroxyprop-2-ynyl)benzoate
Show/Hide
|
C25H28N6O7
|
1
|
| 1 |
Ki = 143 nM
|
|
|
|
CP0454511
|
3-cyano-N-(3-methyl-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C21H20N6O2
|
1
|
| 1 |
Ki = 147 nM
|
|
|
|
CP0566772
|
US9029393, 125
Show/Hide
|
C20H15N5O3
|
1
|
| 1 |
Ki = 147 nM
|
|
|
|
CP0079503
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenyl-urea
Show/Hide
|
C21H20N8O2
|
1
|
| 1 |
Ki = 148 nM
|
|
|
|
CP0464716
|
8-isopropyl-2,6-diphenyl-9H-purine
Show/Hide
|
C20H18N4
|
1
|
| 1 |
Ki = 148 nM
|
|
|
|
CP0405202
|
8-(1-benzylpyrazol-4-yl)-1-(cyclopropylmethyl)-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C20H20N6O2
|
1
|
| 1 |
Ki = 149 nM
|
|
|
|
CP0445788
|
(2S,3S,4R,5R)-5-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C17H23ClN6O3S
|
1
|
| 1 |
Ki = 149 nM
|
|
|
|
CP0291713
|
1-(2-Chloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H15ClN8O2
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0453740
|
8-(1-(4-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H23F3N6O2
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0381594
|
(2S,3S,4R,5R)-5-(2-((R,S)-3-cyclopentyl-3-hydroxyprop-1-ynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H30N6O5
|
1
|
| 1 |
Ki = 152 nM
|
|
|
|
CP0390570
|
4-[3-(2-furan-2-yl-8-methy-8H-pyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl)-ureido]pyridinium N-oxide
Show/Hide
|
C17H13N9O3
|
1
|
| 1 |
Ki = 153 nM
|
|
|
|
CP0853889
|
4-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)piperazin-1-ium 2,2,2-trifluoroacetate
Show/Hide
|
C14H15F3N8O3
|
1
|
| 1 |
Ki = 153 nM
|
|
|
|
CP0502120
|
(4-(furan-2-yl)-2-(2-methoxypropylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C18H18N2O3S
|
1
|
| 1 |
Ki = 154 nM
|
|
|
|
CP0454672
|
5-(3-methoxyphenyl)-4-phenylpyrimidin-2-amine
Show/Hide
|
C17H15N3O
|
1
|
| 1 |
Ki = 154 nM
|
|
|
|
CP0881058
|
5-[[(3-pyridyl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine hydrochloride
Show/Hide
|
C17H14ClN9O2
|
1
|
| 1 |
Ki = 155 nM
|
|
|
|
CP0461821
|
N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutanamide
Show/Hide
|
C21H21N3O
|
1
|
| 1 |
Ki = 157 nM
|
|
|
|
CP0394319
|
N-(5-cyano-4,6-diphenylpyrimidin-2-yl)-4-methylbenzamide
Show/Hide
|
C25H18N4O
|
1
|
| 1 |
Ki = 158 nM
|
|
|
|
CP0378001
|
(2-chloropurin-9-yl)-3,4-dihydroxytetrahydrothiphene-2-carboxylic acid methyl amide
Show/Hide
|
C11H13ClN6O3S
|
1
|
| 1 |
Ki = 158 nM
|
|
|
|
CP0433617
|
N-(5-cyano-4,6-diphenylpyrimidin-2-yl)cyclopentanecarboxamide
Show/Hide
|
C23H20N4O
|
1
|
| 1 |
Ki = 159 nM
|
|
|
|
CP0047376
|
1-(4-Chloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H15ClN8O2
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0133194
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxyphenyl)urea
Show/Hide
|
C19H16N8O3
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0417762
|
(4-(furan-2-yl)-2-((furan-2-ylmethyl)(methyl)amino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C20H16N2O3S
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0373872
|
2-Amino-4-[3,4-(dimethoxy)phenyl]-6-phenyl-3-pyridinecarbonitrile
Show/Hide
|
C20H17N3O2
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0395527
|
2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Show/Hide
|
C8H7N7O
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0495555
|
methyl (2S)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-phenylpropanoate
Show/Hide
|
C33H40N8O7
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0453613
|
2-amino-4-phenylpyrimidine-5-carbonitrile
Show/Hide
|
C11H8N4
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0123309
|
2-amino-8-pyrimidin-5-yl-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C23H17N7O
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0497721
|
2-amino-8-fluoro-N-(2-phenylethyl)quinazoline-4-carboxamide
Show/Hide
|
C17H15FN4O
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0467289
|
8-propyl-2,6-diphenyl-9H-purine
Show/Hide
|
C20H18N4
|
1
|
| 1 |
Ki = 167 nM
|
|
|
|
CP0408804
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexanecarboxylic acid (2-dimethylamino-ethyl)-amide
Show/Hide
|
C22H36N6O3
|
1
|
| 1 |
Ki = 168 nM
|
|
|
|
CP0433706
|
2,6-diphenylpyrimidin-4-amine
Show/Hide
|
C16H13N3
|
1
|
| 1 |
Ki = 169 nM
|
|
|
|
CP0248025
|
1,3,5-Trimethyl-6-((E)-styryl)-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H17N3O2
|
1
|
| 1 |
Ki = 170 nM
|
|
|
|
CP0555919
|
US9029393, 7
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
Ki = 171 nM
|
|
|
|
CP0563902
|
US9029393, 71
Show/Hide
|
C24H19N3O2
|
1
|
| 1 |
Ki = 171 nM
|
|
|
|
CP0444809
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3-phenylmethoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C24H25N7O5
|
1
|
| 1 |
Ki = 173 nM
|
|
|
|
CP0399847
|
3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino)-thiazol-4-yl]-benzonitrile
Show/Hide
|
C20H16N6S
|
1
|
| 1 |
Ki = 175 nM
|
|
|
|
CP0555920
|
US9029393, 85
Show/Hide
|
C23H22F3N5O
|
1
|
| 1 |
Ki = 177 nM
|
|
|
|
CP0392768
|
(2R,3R,4R)-2-[6-amino-2-[(E)-hex-1-enyl]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C15H21N5O3
|
1
|
| 1 |
Ki = 178 nM
|
|
|
|
CP0405705
|
N-(2,6-diphenylpyrimidin-4-yl)cyclobutanecarboxamide
Show/Hide
|
C21H19N3O
|
1
|
| 1 |
Ki = 179 nM
|
|
|
|
CP0493379
|
3-cyano-N-(6-(piperidine-1-carbonyl)-3-(tetrahydro-2H-pyran-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C25H26N6O3
|
1
|
| 1 |
Ki = 179 nM
|
|
|
|
CP0079480
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxyphenyl)urea
Show/Hide
|
C19H16N8O3
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0210735
|
1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13ClN8O2
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0222481
|
1-(3-Chloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H15ClN8O2
|
2
|
| 1 |
Ki = 180 nM
|
|
|
| 2 |
Ki = 185 nM
|
|
|
|
CP0871056
|
5-[[(2-pyridyl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine hydrochloride
Show/Hide
|
C17H14ClN9O2
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0392913
|
(2S)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]butanedioic acid
Show/Hide
|
C27H34N8O9
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0198142
|
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-(2,2,2-trifluoroethyl)oxolane-2-carboxamide
Show/Hide
|
C12H13F3N6O4
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0510183
|
2-amino-8-methoxy-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]quinazoline-4-carboxamide
Show/Hide
|
C19H19N5O2
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0373142
|
8-(1-benzylpyrazol-4-yl)-1-(cyclopropylmethyl)-3-ethyl-7H-purine-2,6-dione
Show/Hide
|
C21H22N6O2
|
1
|
| 1 |
Ki = 181 nM
|
|
|
|
CP0273477
|
N-(4-chlorophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C25H26ClN5O4
|
1
|
| 1 |
Ki = 187 nM
|
|
|
|
CP0518262
|
US9029393, 56
Show/Hide
|
C23H19N3O2
|
1
|
| 1 |
Ki = 188 nM
|
|
|
|
CP0385992
|
N-(2,6-diphenylpyrimidin-4-yl)cyclopropanecarboxamide
Show/Hide
|
C20H17N3O
|
1
|
| 1 |
Ki = 189 nM
|
|
|
|
CP0460956
|
9-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17ClFN5O2
|
1
|
| 1 |
Ki = 189 nM
|
|
|
|
CP0040261
|
BW-A1433
Show/Hide
|
C20H22N4O4
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0202130
|
(2R,3R,4S,5R)-2-{6-Amino-2-[4-(4-methoxy-phenyl)-pyrazol-1-yl]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C20H21N7O5
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0516551
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-methyl-1,3-oxazol-5-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C20H26N8O2
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0373886
|
2-Amino-4-(3,4-dichloro-phenyl)-6-furan-2-yl-nicotinonitrile
Show/Hide
|
C16H9Cl2N3O
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0378491
|
3-ethyl-8-[1-[[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C24H26FN7O3
|
1
|
| 1 |
Ki = 192 nM
|
|
|
|
CP0462675
|
(4-(furan-2-yl)-2-(2-methoxyethylamino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C17H16N2O3S
|
1
|
| 1 |
Ki = 195 nM
|
|
|
|
CP0393761
|
(2S,3S,4R,5R)-3,4-dihydroxy-N-methyl-5-[6-(naphthalen-2-ylmethylamino)purin-9-yl]selenolane-2-carboxamide
Show/Hide
|
C22H22N6O3Se
|
1
|
| 1 |
Ki = 195 nM
|
|
|
|
CP0432967
|
N-(2,6-diphenylpyrimidin-4-yl)cyclopentanecarboxamide
Show/Hide
|
C22H21N3O
|
1
|
| 1 |
Ki = 196 nM
|
|
|
|
CP0047373
|
1-(2-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13ClN8O2
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0378785
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C17H15FN6O2
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0037770
|
(R)-N-(3-phenyl-1H-1,2,4-triazol-5-yl)-2-(m-tolyloxy)propanamide
Show/Hide
|
C18H18N4O2
|
2
|
| 1 |
Ki = 200 nM
|
|
|
| 2 |
Ki = 1200 nM
|
|
|
|
CP0150343
|
(4,6-dimethylpyrimidin-2-ylamino)(2-(5-fluoro-1H-indol-3-yl)ethylamino)methaniminium
Show/Hide
|
C17H19FN6
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0445357
|
1-(2-methoxyphenyl)-3-(5-phenyl-1H-1,2,4-triazol-3-yl)urea
Show/Hide
|
C16H15N5O2
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0445407
|
2-methoxy-N-(5-phenyl-1H-1,2,4-triazol-3-yl)benzamide
Show/Hide
|
C16H14N4O2
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0462143
|
7-amino-2-(furan-2-yl)-4H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-one
Show/Hide
|
C8H6N6O2
|
1
|
| 1 |
Ki = 201 nM
|
|
|
|
CP0047370
|
1-(3-Chloro-phenyl)-3-[2-furan-2-yl-8-(3-phenyl-propyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-urea
Show/Hide
|
C26H21ClN8O2
|
1
|
| 1 |
Ki = 202 nM
|
|
|
|
CP0455654
|
(2S,3S,4R,5R)-5-[2-chloro-6-(2-methyl-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-thiophene-2-carboxylic acid cyclopropylamide
Show/Hide
|
C21H23ClN6O3S
|
1
|
| 1 |
Ki = 202 nM
|
|
|
|
CP0175614
|
8-(3-chlorostyryl)caffeine
Show/Hide
|
C16H15ClN4O2
|
1
|
| 1 |
Ki = 204.2 nM
|
|
|
|
CP0375020
|
(R)-1-[6-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]pyrrolidine-2-carboxylic Acid Methyl Ester
Show/Hide
|
C17H22N6O3
|
1
|
| 1 |
Ki = 205 nM
|
|
|
|
CP0514724
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-(3-(trifluoromethoxy)phenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H20F3N5O3
|
1
|
| 1 |
Ki = 206 nM
|
|
|
|
CP0376070
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(3-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 207 nM
|
|
|
|
CP0386012
|
N-(2,6-diphenylpyrimidin-4-yl)cyclohexanecarboxamide
Show/Hide
|
C23H23N3O
|
1
|
| 1 |
Ki = 208 nM
|
|
|
|
CP0477487
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-pyridin-2-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H22N8O4
|
1
|
| 1 |
Ki = 208 nM
|
|
|
|
CP0540552
|
2-(3-fluorobenzamido)-N-(3-methoxybenzyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxamide
Show/Hide
|
C27H27FN4O4
|
1
|
| 1 |
Ki = 210 nM
|
|
|
|
CP0198141
|
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-propyloxolane-2-carboxamide
Show/Hide
|
C13H18N6O4
|
1
|
| 1 |
Ki = 210 nM
|
|
|
|
CP0431086
|
[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-(4-nitrophenyl)methanone
Show/Hide
|
C19H17N9O4
|
1
|
| 1 |
Ki = 212 nM
|
|
|
|
CP0527088
|
2-(cyclopentylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
Ki = 213 nM
|
|
|
|
CP0309505
|
2-((1H-imidazol-2-yl)methylthio)-6-amino-4-(4-methoxyphenyl)pyridine-3,5-dicarbonitrile
Show/Hide
|
C18H14N6OS
|
1
|
| 1 |
Ki = 214 nM
|
|
|
|
CP0455801
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-imidazol-1-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H21N9O4
|
1
|
| 1 |
Ki = 216 nM
|
|
|
|
CP0394511
|
1-butyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C20H21FN6O2
|
1
|
| 1 |
Ki = 217 nM
|
|
|
|
CP0461654
|
8-(1-(3-phenylpropyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 220 nM
|
|
|
|
CP0483424
|
5-(1-(2-Acetamidoethyl)-1H-1,2,3-triazol-4-yl)-N-(2-(2-(4-(3-(5-amino-2-(furan-2-yl)-7Hpyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetamido)ethyl)pentanamide
Show/Hide
|
C34H41N13O5
|
1
|
| 1 |
Ki = 220 nM
|
|
|
|
CP0433705
|
N-[6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-yl]butanamide
Show/Hide
|
C21H19N3O3
|
1
|
| 1 |
Ki = 222 nM
|
|
|
|
CP0856049
|
N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylamide
Show/Hide
|
C26H28N6O5
|
1
|
| 1 |
Ki = 223 nM
|
|
|
|
CP0118650
|
(2S,3S,4R,5R)-5-(2-chloro-6-(3-iodobenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrothiophene-2-carboxamide
Show/Hide
|
C18H18ClIN6O3S
|
1
|
| 1 |
Ki = 223 nM
|
|
|
|
CP0444814
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-propoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H25N7O5
|
1
|
| 1 |
Ki = 224 nM
|
|
|
|
CP0432962
|
N-(4,6-diphenylpyrimidin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C20H17N3O
|
1
|
| 1 |
Ki = 228 nM
|
|
|
|
CP0109444
|
(2R,3R,4S)-2-(6-(3-Iodobenzylamino)-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol
Show/Hide
|
C16H16IN5O2S
|
2
|
| 1 |
Ki = 230 nM
|
|
|
| 2 |
Ki = 440 nM
|
|
|
|
CP0378789
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23FN6O2
|
1
|
| 1 |
Ki = 230 nM
|
|
|
|
CP0529709
|
1,3-Dipropyl-8-(1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C14H18N6O2
|
1
|
| 1 |
Ki = 230 nM
|
|
|
|
CP0532361
|
8-(1-(2-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H23F3N6O2
|
1
|
| 1 |
Ki = 230 nM
|
|
|
|
CP0405203
|
1-ethyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C18H17FN6O2
|
1
|
| 1 |
Ki = 231 nM
|
|
|
|
CP0535810
|
3-cyano-N-(6-(piperidine-1-carbonyl)-3-(pyridin-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C26H23N7O2
|
1
|
| 1 |
Ki = 233 nM
|
|
|
|
CP0391195
|
1-(cyclopropylmethyl)-3-ethyl-8-(1H-pyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C14H16N6O2
|
1
|
| 1 |
Ki = 234 nM
|
|
|
|
CP0407886
|
1-ethyl-3-methyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C19H17F3N6O2
|
1
|
| 1 |
Ki = 234 nM
|
|
|
|
CP0397722
|
2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-(4-trifluoromethyl-phenyl)-acetamide
Show/Hide
|
C26H26F3N5O4
|
1
|
| 1 |
Ki = 238 nM
|
|
|
|
CP0339399
|
(2S,3S,4R,5R)-5-[2-chloro-6-[(3-chlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H18Cl2N6O3Se
|
1
|
| 1 |
Ki = 238 nM
|
|
|
|
CP0519959
|
2-(3,4-dimethoxyphenyl)-6-(furan-2-yl)imidazo[1,2-a]pyridine
Show/Hide
|
C19H16N2O3
|
1
|
| 1 |
Ki = 238 nM
|
|
|
|
CP0445455
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(quinolin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C23H22N8O5
|
1
|
| 1 |
Ki = 239 nM
|
|
|
|
CP0444812
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(5-bromopyridin-2-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C16H17BrN8O4
|
1
|
| 1 |
Ki = 239 nM
|
|
|
|
CP0415261
|
2-amino-N-[(4-butoxyquinolin-8-yl)methyl]-8-fluoroquinazoline-4-carboxamide
Show/Hide
|
C23H22FN5O2
|
1
|
| 1 |
Ki = 245 nM
|
|
|
|
CP0309227
|
6-[(E)-2-(4-methoxyphenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H19N3O3
|
1
|
| 1 |
Ki = 246.6 nM
|
|
|
|
CP0485720
|
8-(1-benzylpyrazol-4-yl)-1-butyl-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 247 nM
|
|
|
|
CP0441668
|
4-(3-(8-ethyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C19H16N8O5S
|
1
|
| 1 |
Ki = 249 nM
|
|
|
|
CP0446699
|
5-(3-chloro-4-methoxyphenyl)-4-phenylpyrimidin-2-amine
Show/Hide
|
C17H14ClN3O
|
1
|
| 1 |
Ki = 251 nM
|
|
|
|
CP0553388
|
US9029393, 129
Show/Hide
|
C23H24N4O2
|
1
|
| 1 |
Ki = 256 nM
|
|
|
|
CP0511564
|
7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-2-(2-morpholinoethylamino)-7H-purin-8(9H)-one
Show/Hide
|
C25H26F2N6O3
|
1
|
| 1 |
Ki = 259 nM
|
|
|
|
CP0142276
|
6-[(E)-2-(4-chlorophenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H16ClN3O2
|
1
|
| 1 |
Ki = 260 nM
|
|
|
|
CP0375018
|
2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxymethylpyrrolidin-1-yl)pyrimidin-4-ylamine
Show/Hide
|
C15H22N6O
|
1
|
| 1 |
Ki = 261 nM
|
|
|
|
CP0407847
|
8-(1-benzylpyrazol-4-yl)-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 261 nM
|
|
|
|
CP0529815
|
7-(2,6-difluorobenzyl)-2-(2-(dimethylamino)ethylamino)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H24F2N6O2
|
1
|
| 1 |
Ki = 261 nM
|
|
|
|
CP0515102
|
US9029393, 23
Show/Hide
|
C22H24N4O2
|
1
|
| 1 |
Ki = 264 nM
|
|
|
|
CP0398836
|
(2S,3S,4R,5R)-5-[6-amino-2-[2-[4-[3-(4-hydroxy-3-nitroanilino)-3-oxopropyl]phenyl]ethylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C29H33N9O8
|
1
|
| 1 |
Ki = 267 nM
|
|
|
|
CP0856391
|
3-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)propan-1-aminium 2,2,2-trifluoroacetate
Show/Hide
|
C13H15F3N8O3
|
1
|
| 1 |
Ki = 270 nM
|
|
|
|
CP0404771
|
6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine
Show/Hide
|
C17H15N5O
|
1
|
| 1 |
Ki = 270.5 nM
|
|
|
|
CP0437175
|
1-(cyclopropylmethyl)-3-ethyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H21F3N6O2
|
1
|
| 1 |
Ki = 272 nM
|
|
|
|
CP0388777
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(2-methoxyethyl)piperidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C19H28N6O2
|
1
|
| 1 |
Ki = 275 nM
|
|
|
|
CP0453841
|
1'S, 2'R, 3'S, 4'S, 5'S)-4'-[6-(3-Chlorobenzylamino)-2-(6-(beta-aminoethylaminocarbonyl)-1-hexynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C29H35ClN8O4
|
1
|
| 1 |
Ki = 277 nM
|
|
|
|
CP0432045
|
N-(5-cyano-2,6-diphenylpyrimidin-4-yl)cyclopentanecarboxamide
Show/Hide
|
C23H20N4O
|
1
|
| 1 |
Ki = 280 nM
|
|
|
|
CP0456957
|
8-(1-(3,4-difluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1Hpurine-2,6(3H,7H)-dione
Show/Hide
|
C21H22F2N6O2
|
1
|
| 1 |
Ki = 280 nM
|
|
|
|
CP0495406
|
N-[2-[[5-benzoyl-4-(furan-2-yl)-1,3-thiazol-2-yl]amino]ethyl]acetamide
Show/Hide
|
C18H17N3O3S
|
1
|
| 1 |
Ki = 281 nM
|
|
|
|
CP0847039
|
4-[3-(2-furan-2-yl-8-methy-8H-pyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl)-ureido]-N-methylpyridinium iodide
Show/Hide
|
C18H16IN9O2
|
1
|
| 1 |
Ki = 282 nM
|
|
|
|
CP0395528
|
1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-dichloroethanone
Show/Hide
|
C14H14Cl2N8O2
|
1
|
| 1 |
Ki = 282 nM
|
|
|
|
CP0467287
|
2-tolyl-6-phenyl-9H-purine
Show/Hide
|
C18H14N4
|
1
|
| 1 |
Ki = 289 nM
|
|
|
|
CP0405104
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H24N6O2
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0436497
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H19FN6O2
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0541870
|
US9029393, 111
Show/Hide
|
C27H30FN7O2
|
1
|
| 1 |
Ki = 291 nM
|
|
|
|
CP0393331
|
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C19H20ClIN6O3S
|
1
|
| 1 |
Ki = 292 nM
|
|
|
|
CP0887567
|
triethylamine hemi(2-((1E,3E,5E)-5-(3-(6-(4-(2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetamido)butylamino)-6-oxohexyl)-3-methyl-5-sulfonato-1-(3-sulfonatopropyl)indolin-2-ylidene)penta-1,3-dienyl)-3,3-dimethyl-1-(3-sulfonatopropyl)-3H-indolium-5-sulfonate)
Show/Hide
|
C73H103N13O16S4
|
1
|
| 1 |
Ki = 295 nM
|
|
|
|
CP0054092
|
1-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-1H-pyrazole-4-carboxylic acid methylamide
Show/Hide
|
C15H18N8O5
|
2
|
| 1 |
Ki = 297 nM
|
|
|
| 2 |
Ki = 1269 nM
|
|
|
|
CP0464245
|
N-(5-cyano-4,6-diphenylpyrimidin-2-yl)-4-methoxybenzamide
Show/Hide
|
C25H18N4O2
|
1
|
| 1 |
Ki = 300 nM
|
|
|
|
CP0449474
|
4-methyl-N-(5-phenyl-1H-1,2,4-triazol-3-yl)benzamide
Show/Hide
|
C16H14N4O
|
1
|
| 1 |
Ki = 300 nM
|
|
|
|
CP0407882
|
8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-1-(2-methylpropyl)-7H-purine-2,6-dione
Show/Hide
|
C20H21FN6O2
|
1
|
| 1 |
Ki = 301 nM
|
|
|
|
CP0382067
|
4-(3-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C20H18N8O5S
|
1
|
| 1 |
Ki = 305 nM
|
|
|
|
CP0053426
|
N-[4-(furan-2-yl)-11-propyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C21H19N7O2
|
1
|
| 1 |
Ki = 306 nM
|
|
|
|
CP0248024
|
1,3,5-trimethyl-6-[(E)-2-(4-propoxyphenyl)ethenyl]pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C20H23N3O3
|
1
|
| 1 |
Ki = 306.9 nM
|
|
|
|
CP0410095
|
(E)-7-(3-(4-(cinnamyloxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C27H23N7O2
|
1
|
| 1 |
Ki = 308 nM
|
|
|
|
CP0373146
|
1-(cyclopropylmethyl)-3-methyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C21H19F3N6O2
|
1
|
| 1 |
Ki = 312 nM
|
|
|
|
CP0407840
|
3-ethyl-1-propyl-8-(1-((pyridin-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C18H19N7O2
|
1
|
| 1 |
Ki = 312 nM
|
|
|
|
CP0419617
|
8-(4-hydroxymethyl-cyclohexyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C18H28N4O3
|
1
|
| 1 |
Ki = 313 nM
|
|
|
|
CP0494655
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-morpholin-4-ylpyrimidin-4-yl]acetamide
Show/Hide
|
C15H20N6O2
|
1
|
| 1 |
Ki = 313 nM
|
|
|
|
CP0483334
|
2-(4-chlorophenyl)-6-phenyl-9H-purine
Show/Hide
|
C17H11ClN4
|
1
|
| 1 |
Ki = 315 nM
|
|
|
|
CP0522423
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-m-tolyl-7H-purin-8(9H)-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
Ki = 316 nM
|
|
|
|
CP0918296
|
5-methyl-3-(4-methylthiazol-2-yl)-4H-chromen-4-one
Show/Hide
|
C14H11NO2S
|
1
|
| 1 |
Ki = 316.23 nM
|
|
|
|
CP0376044
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(5-phenylpent-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C25H30N6O4
|
1
|
| 1 |
Ki = 321 nM
|
|
|
|
CP0445405
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C17H24N6O2
|
1
|
| 1 |
Ki = 324 nM
|
|
|
|
CP0441869
|
(2S,3S,4R,5R)-5-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)-N-cyclopropyl-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C16H19ClN6O3S
|
1
|
| 1 |
Ki = 325 nM
|
|
|
|
CP0502279
|
3-cyano-N-(3-(3-methoxyphenyl)-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C27H24N6O3
|
1
|
| 1 |
Ki = 325 nM
|
|
|
|
CP0455650
|
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-N-cyclopropyl-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C20H20ClIN6O3S
|
1
|
| 1 |
Ki = 326 nM
|
|
|
|
CP0422859
|
5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[9-[4-[5-[2-[[2-[4-[3-[7-amino-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-10-yl]propyl]phenoxy]acetyl]amino]ethylamino]-5-oxopentyl]triazol-1-yl]-3-oxononoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
Show/Hide
|
C57H81N15O11S
|
1
|
| 1 |
Ki = 330 nM
|
|
|
|
CP0887566
|
triethylamine hemi(2-((1E,3E,5E)-5-(3-(6-(2-(2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetamido)ethylamino)-6-oxohexyl)-3-methyl-5-sulfonato-1-(3-sulfonatopropyl)indolin-2-ylidene)penta-1,3-dienyl)-3,3-dimethyl-1-(3-sulfonatopropyl)-3H-indolium-5-sulfonate)
Show/Hide
|
C71H99N13O16S4
|
1
|
| 1 |
Ki = 332 nM
|
|
|
|
CP0432044
|
N-[6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-yl]cyclopentanecarboxamide
Show/Hide
|
C23H21N3O3
|
1
|
| 1 |
Ki = 339 nM
|
|
|
|
CP0081307
|
(2R,3R,4S)-2-(2-chloro-6-(3-iodobenzylamino)-9H-purin-9-yl)tetrahydrothiophene3,4-diol
Show/Hide
|
C16H15ClIN5O2S
|
1
|
| 1 |
Ki = 341 nM
|
|
|
|
CP0503048
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(1-hydroxycyclohexyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H30N6O5
|
1
|
| 1 |
Ki = 344 nM
|
|
|
|
CP0427801
|
[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-phenylmethanone
Show/Hide
|
C19H18N8O2
|
1
|
| 1 |
Ki = 348 nM
|
|
|
|
CP0553389
|
US9029393, 134
Show/Hide
|
C22H21FN4O
|
1
|
| 1 |
Ki = 348 nM
|
|
|
|
CP0883774
|
3-[5-Imidazol-1-yl-2-(pyrazin-2-ylamino)-thiazol-4-yl]-benzonitrile
Show/Hide
|
C17H11N7S
|
1
|
| 1 |
Ki = 349 nM
|
|
|
|
CP0390572
|
5-[[(2-furyl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H12N8O3
|
1
|
| 1 |
Ki = 350 nM
|
|
|
|
CP0079482
|
1-(3,4-Dichloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H14Cl2N8O2
|
1
|
| 1 |
Ki = 352 nM
|
|
|
|
CP0398582
|
4-(3-(8-butyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C21H20N8O5S
|
1
|
| 1 |
Ki = 352 nM
|
|
|
|
CP0435642
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(quinazolin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C22H21N9O5
|
1
|
| 1 |
Ki = 357 nM
|
|
|
|
CP0513251
|
5-((2-(2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetamido)ethyl)carbamoyl)-2-(6-(dimethylamino)-3-(dimethylimino)-3Hxanthen-9-yl)benzoate
Show/Hide
|
C48H45N11O7
|
1
|
| 1 |
Ki = 357 nM
|
|
|
|
CP0474808
|
2-(cyclopropylamino)-9-(3-methoxyphenyl)-7-(1-phenylethyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
Ki = 359 nM
|
|
|
|
CP0270772
|
(2R,3R,4S,5R)-2-(6-amino-2-(phenylethynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Show/Hide
|
C18H17N5O4
|
1
|
| 1 |
Ki = 363 nM
|
|
|
|
CP0420992
|
6-[(3-bromophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H16BrN5O2
|
1
|
| 1 |
Ki = 369 nM
|
|
|
|
CP0723618
|
SID56462968
Show/Hide
|
C28H32N8O6
|
1
|
| 1 |
Ki = 370 nM
|
|
|
|
CP0424936
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(2-nitrophenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H25N7O7
|
1
|
| 1 |
Ki = 371 nM
|
|
|
|
CP0277666
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(8-butyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C22H20N8O4
|
1
|
| 1 |
Ki = 376 nM
|
|
|
|
CP0432961
|
N-(2,6-diphenylpyrimidin-4-yl)-2-methylpropanamide
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
Ki = 376 nM
|
|
|
|
CP0273529
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenylurea
Show/Hide
|
C18H14N8O2
|
1
|
| 1 |
Ki = 381 nM
|
|
|
|
CP0430642
|
6-Furan-2-yl-9-(1-phenyl-ethyl)-9H-purin-2-ylamine
Show/Hide
|
C17H15N5O
|
1
|
| 1 |
Ki = 381 nM
|
|
|
|
CP0412863
|
4-(1,3-benzodioxol-5-yl)-6-phenylpyrimidin-2-amine
Show/Hide
|
C17H13N3O2
|
1
|
| 1 |
Ki = 381 nM
|
|
|
|
CP0386013
|
N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutanamide
Show/Hide
|
C22H23N3O
|
1
|
| 1 |
Ki = 381 nM
|
|
|
|
CP0248054
|
6-[(E)-2-(3-methoxyphenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H19N3O3
|
1
|
| 1 |
Ki = 390.5 nM
|
|
|
|
CP0079509
|
N-[11-butyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C22H21N7O2
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0500973
|
1,3-Dimethyl-8-[3-(2-pyrrolidin-1-ylethoxy)-phenyl]xanthine
Show/Hide
|
C19H23N5O3
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0508092
|
8-[3-(2-Dimethylaminoethoxy)phenyl]-1,3-dimethylxanthine
Show/Hide
|
C17H21N5O3
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0515731
|
8-[3-(2-Dimethylaminoethoxy)-4-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C18H23N5O4
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0386629
|
5-[[(3-furyl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H12N8O3
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0372912
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H23F3N6O2
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0383384
|
1-(4,6-dimethyl-2-pyrimidinyl)-2-[2-(1H-indol-3-yl)ethyl]guanidine
Show/Hide
|
C17H20N6
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0482978
|
(4,6-dimethylpyrimidin-2-ylamino)(2-(thiophen-3-yl)ethylamino)methaniminium
Show/Hide
|
C13H17N5S
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0275745
|
N-(5-phenyl-1H-1,2,4-triazol-3-yl)benzamide
Show/Hide
|
C15H12N4O
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0079484
|
1-(3,4-Dichloro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H16Cl2N8O2
|
1
|
| 1 |
Ki = 401 nM
|
|
|
|
CP0376069
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(3-nitrophenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H25N7O7
|
1
|
| 1 |
Ki = 401 nM
|
|
|
|
CP0409505
|
4,6-diphenylpyrimidin-2-amine
Show/Hide
|
C16H13N3
|
1
|
| 1 |
Ki = 405 nM
|
|
|
|
CP0373147
|
8-(1-benzylpyrazol-4-yl)-3-methyl-1-(2-methylpropyl)-7H-purine-2,6-dione
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 408 nM
|
|
|
|
CP0440678
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-phenyl-7H-purin-8(9H)-one
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
Ki = 409 nM
|
|
|
|
CP0382460
|
5-[[(2-methyl-thiophen-3-yl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H14N8O2S
|
1
|
| 1 |
Ki = 410 nM
|
|
|
|
CP0529313
|
3-ethyl-1-propyl-8-(1-pyridin-2-ylpyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C18H19N7O2
|
1
|
| 1 |
Ki = 411 nM
|
|
|
|
CP0518089
|
8-(4-hydroxymethyl-bicyclo[2.2.2]oct-1-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C20H30N4O3
|
1
|
| 1 |
Ki = 414 nM
|
|
|
|
CP0389915
|
6-(furan-2-yl)-2-phenylimidazo[1,2-a]pyridin-8-amine
Show/Hide
|
C17H13N3O
|
1
|
| 1 |
Ki = 418 nM
|
|
|
|
CP0514766
|
(2R,3R,4S)-2-(6-(3-Bromobenzylamino)-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol
Show/Hide
|
C16H16BrN5O2S
|
1
|
| 1 |
Ki = 420 nM
|
|
|
|
CP0405106
|
8-(1-((5-phenylisoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H25N7O3
|
1
|
| 1 |
Ki = 420 nM
|
|
|
|
CP0258311
|
N-[4-(furan-2-yl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C19H15N7O2
|
1
|
| 1 |
Ki = 423 nM
|
|
|
|
CP0144418
|
6-[(E)-2-(4-fluorophenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H16FN3O2
|
1
|
| 1 |
Ki = 423.4 nM
|
|
|
|
CP0391612
|
(2S,3S,4R,5R)-5-[2-chloro-6-(2-methyl-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-thiophene-2-carboxylic acid ethylamide
Show/Hide
|
C20H23ClN6O3S
|
1
|
| 1 |
Ki = 429 nM
|
|
|
|
CP0132440
|
6-[(E)-2-(3-chlorophenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H16ClN3O2
|
1
|
| 1 |
Ki = 430 nM
|
|
|
|
CP0397463
|
N-(2-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 431 nM
|
|
|
|
CP0374550
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(pyridin-2-yloxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
Ki = 439 nM
|
|
|
|
CP0526299
|
2-(3-chlorobenzamido)-N-(3-methoxybenzyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxamide
Show/Hide
|
C27H27ClN4O4
|
1
|
| 1 |
Ki = 439 nM
|
|
|
|
CP0459671
|
(2R,3R,4S)-2-(6-(3-Chlorobenzylamino)-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol
Show/Hide
|
C16H16ClN5O2S
|
1
|
| 1 |
Ki = 440 nM
|
|
|
|
CP0436473
|
3-methyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki = 450 nM
|
|
|
|
CP0471401
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki = 450 nM
|
|
|
|
CP0494654
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[2-(ethoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C18H26N6O2
|
1
|
| 1 |
Ki = 455 nM
|
|
|
|
CP0481702
|
1-(4-(5-benzoyl-4-(furan-2-yl)thiazol-2-ylamino)piperidin-1-yl)ethanone
Show/Hide
|
C21H21N3O3S
|
1
|
| 1 |
Ki = 455 nM
|
|
|
|
CP0553377
|
US9029393, 139
Show/Hide
|
C22H23ClN4O2
|
1
|
| 1 |
Ki = 459 nM
|
|
|
|
CP0378787
|
8-(1-(2-fluoro-3-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H25FN6O2
|
1
|
| 1 |
Ki = 460 nM
|
|
|
|
CP0432813
|
3-ethyl-8-[1-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C25H26F3N7O3
|
1
|
| 1 |
Ki = 460 nM
|
|
|
|
CP0683797
|
US9227979, 2
Show/Hide
|
C35H27N9O6S
|
1
|
| 1 |
Ki = 460 nM
|
|
|
|
CP0217091
|
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Show/Hide
|
C11H14N6O4
|
1
|
| 1 |
Ki = 466 nM
|
|
|
|
CP0381502
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((S)-3-hydroxyoct-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H32N6O5
|
1
|
| 1 |
Ki = 467 nM
|
|
|
|
CP0066695
|
6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H17N3O4
|
1
|
| 1 |
Ki = 467.3 nM
|
|
|
|
CP0118648
|
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyl-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C18H19IN6O3S
|
1
|
| 1 |
Ki = 475 nM
|
|
|
|
CP0505198
|
1-butyl-3-methyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C21H21F3N6O2
|
1
|
| 1 |
Ki = 481 nM
|
|
|
|
CP0435384
|
2-Isopropyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C11H14N8
|
1
|
| 1 |
Ki = 481.3 nM
|
|
|
|
CP0378475
|
3-ethyl-8-[1-[[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C25H29N7O4
|
1
|
| 1 |
Ki = 486 nM
|
|
|
|
CP0386106
|
N-(2,6-diphenylpyrimidin-4-yl)acetamide
Show/Hide
|
C18H15N3O
|
1
|
| 1 |
Ki = 489 nM
|
|
|
|
CP0079505
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3,4-dichloro-phenyl)-urea
Show/Hide
|
C21H18Cl2N8O2
|
1
|
| 1 |
Ki = 495 nM
|
|
|
|
CP0421960
|
3-ethyl-1-propyl-8-(1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C13H16N6O2
|
1
|
| 1 |
Ki = 496 nM
|
|
|
|
CP0436562
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(2-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 497 nM
|
|
|
|
CP0514722
|
2-(cyclopropylmethylamino)-7-(2,6-difluorobenzyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
Ki = 499 nM
|
|
|
|
CP0451694
|
2-(4-tert-butylphenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C26H33N3O4S
|
1
|
| 1 |
Ki = 500 nM
|
|
|
|
CP0067050
|
Adenosine analog, 11
Show/Hide
|
C12H16N6O5
|
1
|
| 1 |
Ki = 505 nM
|
|
|
|
CP0169089
|
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-N-cyclopropyl-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C22H27ClN6O3
|
1
|
| 1 |
Ki = 520 nM
|
|
|
|
CP0085564
|
1,3,5-trimethyl-6-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H16F3N3O2
|
1
|
| 1 |
Ki = 530.6 nM
|
|
|
|
CP0432709
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(hex-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C20H28N6O4
|
1
|
| 1 |
Ki = 543 nM
|
|
|
|
CP0455651
|
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-N-cyclobutyl-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C21H22ClIN6O3S
|
1
|
| 1 |
Ki = 549 nM
|
|
|
|
CP0472058
|
(1'S,2'R,3'S,4'S,5'S)-4'-[6-(3-Chlorobenzylamino)-2-(4-(beta-aminoethylaminocarbonyl)-1-butynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic AcidN-Methylamide
Show/Hide
|
C27H31ClN8O4
|
1
|
| 1 |
Ki = 550 nM
|
|
|
|
CP0386867
|
(2S,3S,4R,5R)-5-[6-[(3-chlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H19ClN6O3Se
|
1
|
| 1 |
Ki = 555 nM
|
|
|
|
CP0412865
|
6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-amine
Show/Hide
|
C17H13N3O2
|
1
|
| 1 |
Ki = 557 nM
|
|
|
|
CP0451869
|
8-(1-phenyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 560 nM
|
|
|
|
CP0115515
|
(2S,3S,4R,5R)-5-[6-[(3-bromophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H19BrN6O3Se
|
1
|
| 1 |
Ki = 560 nM
|
|
|
|
CP0856390
|
2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethanaminium 2,2,2-trifluoroacetate
Show/Hide
|
C12H13F3N8O3
|
1
|
| 1 |
Ki = 567 nM
|
|
|
|
CP0525914
|
8-(1-phenethyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 570 nM
|
|
|
|
CP0408091
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(oct-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H32N6O4
|
1
|
| 1 |
Ki = 571 nM
|
|
|
|
CP0433704
|
N-[6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-yl]-2-ethylbutanamide
Show/Hide
|
C23H23N3O3
|
1
|
| 1 |
Ki = 574 nM
|
|
|
|
CP0079483
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(8-ethyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C20H16N8O4
|
1
|
| 1 |
Ki = 576 nM
|
|
|
|
CP0401492
|
4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C18H14N8O5S
|
1
|
| 1 |
Ki = 594 nM
|
|
|
|
CP0057629
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetic acid
Show/Hide
|
C19H22N4O5
|
1
|
| 1 |
Ki = 595 nM
|
|
|
|
CP0501820
|
8-[4-(2-Dimethylaminoethoxy)-3-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C18H23N5O4
|
1
|
| 1 |
Ki = 600 nM
|
|
|
|
CP0522546
|
8-[3-(2-Diethylaminoethoxy)-4-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C20H27N5O4
|
1
|
| 1 |
Ki = 600 nM
|
|
|
|
CP0383385
|
(4,6-dimethylpyrimidin-2-ylamino)(2-(6-methoxy-1H-indol-3-yl)ethylamino)methaniminium
Show/Hide
|
C18H22N6O
|
1
|
| 1 |
Ki = 600 nM
|
|
|
|
CP0378004
|
(2S,3S,4R,5R)-5-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C15H19ClN6O3S
|
1
|
| 1 |
Ki = 604 nM
|
|
|
|
CP0482902
|
9-[(6-chloro-2-fluoro-3-methoxyphenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H19ClFN5O3
|
1
|
| 1 |
Ki = 627 nM
|
|
|
|
CP0436468
|
3-methyl-1-(2-methylpropyl)-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C21H21F3N6O2
|
1
|
| 1 |
Ki = 633 nM
|
|
|
|
CP0381658
|
2-Amino-4-phenyl-6-(1-H-pyrrol-2-yl)-nicotinonitrile
Show/Hide
|
C16H12N4
|
1
|
| 1 |
Ki = 640 nM
|
|
|
|
CP0403028
|
N,N-dibenzyl-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C33H35N5O4
|
1
|
| 1 |
Ki = 642 nM
|
|
|
|
CP0408090
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(4-hydroxybut-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C18H24N6O5
|
1
|
| 1 |
Ki = 642 nM
|
|
|
|
CP0381503
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(3-phenylprop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H26N6O4
|
1
|
| 1 |
Ki = 645 nM
|
|
|
|
CP0379088
|
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopentyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C15H20N6O4
|
1
|
| 1 |
Ki = 650 nM
|
|
|
|
CP0250680
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C21H18N8O4
|
1
|
| 1 |
Ki = 667 nM
|
|
|
|
CP0373080
|
3-ethyl-8-[1-(6-methylpyridin-3-yl)pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C19H21N7O2
|
1
|
| 1 |
Ki = 670 nM
|
|
|
|
CP0386543
|
3-noradamantyl-1,3-dipropylxanthine
Show/Hide
|
C20H28N4O2
|
1
|
| 1 |
Ki = 673 nM
|
|
|
|
CP0189851
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(2-phenylethylamino)purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C18H21N5O4
|
1
|
| 1 |
Ki = 676 nM
|
|
|
|
CP0348518
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C19H14N8O4
|
1
|
| 1 |
Ki = 680 nM
|
|
|
|
CP0453295
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R)-3-hydroxyoct-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H32N6O5
|
1
|
| 1 |
Ki = 680 nM
|
|
|
|
CP0423646
|
(1R,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C26H22ClN5O2
|
1
|
| 1 |
Ki = 680 nM
|
|
|
|
CP0441857
|
CHEMBL424908
Show/Hide
|
C23H33N5O5
|
1
|
| 1 |
Ki = 681 nM
|
|
|
|
CP0853682
|
(2R,3R,4S,5R)-2-(6-Amino-2-((E)-2-(4-methoxybenzylidene)hydrazinyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Show/Hide
|
C18H21N7O5
|
1
|
| 1 |
Ki = 687 nM
|
|
|
|
CP0394216
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C18H15F3N6O2
|
1
|
| 1 |
Ki = 690 nM
|
|
|
|
CP0515729
|
1,3-Dimethyl-8-[3-methoxy-4-(2-piperidin-1-ylethoxy)-phenyl]xanthine
Show/Hide
|
C21H27N5O4
|
1
|
| 1 |
Ki = 700 nM
|
|
|
|
CP0953877
|
SID846109
Show/Hide
|
C16H17N5OS
|
1
|
| 1 |
Ki = 707.95 nM
|
|
|
|
CP0451808
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(4-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 711 nM
|
|
|
|
CP0433746
|
1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C19H24N8O6
|
1
|
| 1 |
Ki = 726 nM
|
|
|
|
CP0401241
|
(1'S, 2'R, 3'S, 4'S, 5'S)-4'-[6-(3-Chlorobenzylamino)-2-(4-(delta-aminobutylaminocarbonyl)-1-butynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C29H35ClN8O4
|
1
|
| 1 |
Ki = 766 nM
|
|
|
|
CP0410873
|
10-[(2-bromophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20BrN5O2
|
1
|
| 1 |
Ki = 767 nM
|
|
|
|
CP0407888
|
8-[1-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl]pyrazol-4-yl]-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C23H22ClN7O3
|
1
|
| 1 |
Ki = 781 nM
|
|
|
|
CP0315311
|
(1S,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H20ClIN6O3
|
1
|
| 1 |
Ki = 784 nM
|
|
|
|
CP0460951
|
6-[(2-methoxyphenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C17H19N5O3
|
1
|
| 1 |
Ki = 784 nM
|
|
|
|
CP0376072
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((S)-3-hydroxybut-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C18H24N6O5
|
1
|
| 1 |
Ki = 785 nM
|
|
|
|
CP0049200
|
(2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C15H21N5O4
|
3
|
| 1 |
Ki = 794 nM
|
|
|
| 2 |
Ki = 1652 nM
|
|
|
| 3 |
Ki = 1700 nM
|
|
|
|
CP0408621
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carbaldehyde
Show/Hide
|
C20H28N4O3
|
1
|
| 1 |
Ki = 799 nM
|
|
|
|
CP0474766
|
1,3-Dimethyl-8-[3-(2-piperidin-4-ylethoxy)phenyl]xanthine
Show/Hide
|
C20H25N5O3
|
1
|
| 1 |
Ki = 800 nM
|
|
|
|
CP0069170
|
N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
Show/Hide
|
C31H25N7O2
|
1
|
| 1 |
Ki = 800 nM
|
|
|
|
CP0475464
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-morpholin-4-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H26N8O5
|
1
|
| 1 |
Ki = 800 nM
|
|
|
|
CP0477486
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[4-chloro-3-(trifluoromethyl)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C18H17ClF3N7O4
|
1
|
| 1 |
Ki = 801 nM
|
|
|
|
CP0376622
|
5-[[(quinolin-2-yl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C21H15N9O2
|
1
|
| 1 |
Ki = 810 nM
|
|
|
|
CP0392534
|
2-amino-N-(quinolin-8-ylmethyl)quinoline-4-carboxamide
Show/Hide
|
C20H16N4O
|
1
|
| 1 |
Ki = 836 nM
|
|
|
|
CP0532745
|
(1S,2R,3S,4R,5S)-4-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C22H23FN6O3S
|
1
|
| 1 |
Ki = 838 nM
|
|
|
|
CP0464322
|
8-(1-(3-chloro-2-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H22ClFN6O2
|
1
|
| 1 |
Ki = 870 nM
|
|
|
|
CP0380533
|
2-(2-oxo-3-(thiazol-2-yl)-4-(3,3,3-trifluoropropyl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C26H24F3N3O3S
|
1
|
| 1 |
Ki = 878 nM
|
|
|
|
CP0446833
|
10-[(2-chlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20ClN5O2
|
1
|
| 1 |
Ki = 881 nM
|
|
|
|
CP0146931
|
6-[(E)-2-(6-aminopyridin-2-yl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C16H17N5O2
|
1
|
| 1 |
Ki = 886.8 nM
|
|
|
|
CP0446837
|
6-[(2-bromophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H16BrN5O2
|
1
|
| 1 |
Ki = 887 nM
|
|
|
|
CP0378801
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-dibutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 890 nM
|
|
|
|
CP0461220
|
(1'S, 2'R, 3'S, 4'S, 5'S)-4'-[6-(3-Chlorobenzylamino)-2-(4-(beta-aminoethyl-Naminoethylaminocarbonyl)-1-butanyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C29H36ClN9O4
|
1
|
| 1 |
Ki = 890 nM
|
|
|
|
CP0395863
|
N-(4,6-diphenylpyrimidin-2-yl)propanamide
Show/Hide
|
C19H17N3O
|
1
|
| 1 |
Ki = 893 nM
|
|
|
|
CP0385993
|
N-(2,6-diphenylpyrimidin-4-yl)-2-methylbutanamide
Show/Hide
|
C21H21N3O
|
1
|
| 1 |
Ki = 899 nM
|
|
|
|
CP0393768
|
(2S,3S,4R,5R)-5-[2-chloro-6-(cyclobutylamino)purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C15H19ClN6O3Se
|
1
|
| 1 |
Ki = 899 nM
|
|
|
|
CP0383387
|
(4,6-dimethylpyrimidin-2-ylamino)(4-methoxyphenethylamino)methaniminium
Show/Hide
|
C16H21N5O
|
1
|
| 1 |
Ki = 900 nM
|
|
|
|
CP0529719
|
3-cyano-N-(3-pentyl-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C25H28N6O2
|
1
|
| 1 |
Ki = 904 nM
|
|
|
|
CP0408622
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester
Show/Hide
|
C21H30N4O4
|
1
|
| 1 |
Ki = 912 nM
|
|
|
|
CP0382461
|
5-[[(5-methyl-thiophen-2-yl)amino]carbonyl]amino-8-methyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H14N8O2S
|
1
|
| 1 |
Ki = 920 nM
|
|
|
|
CP0683798
|
US9227979, 4
Show/Hide
|
C37H31N9O6S
|
1
|
| 1 |
Ki = 920 nM
|
|
|
|
CP0455649
|
(2S,3S,4R,5R)-5-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyl-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C16H21ClN6O3S
|
1
|
| 1 |
Ki = 921 nM
|
|
|
|
CP0392537
|
2-amino-8-fluoro-N-(quinolin-4-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
Ki = 927 nM
|
|
|
|
CP0008892
|
Alloxazine
Show/Hide
|
C10H6N4O2
|
1
|
| 1 |
Ki = 935 nM
|
|
|
|
CP0453292
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(1-hydroxycyclopentyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C21H28N6O5
|
1
|
| 1 |
Ki = 935 nM
|
|
|
|
CP0410876
|
10-[(2-methoxyphenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C19H23N5O3
|
1
|
| 1 |
Ki = 959 nM
|
|
|
|
CP0461221
|
(1'S, 2'R, 3'S, 4'S, 5'S)-4'-[6-(3-Chlorobenzylamino)-2-(4-(gamma-aminopropylaminocarbonyl)-1-butynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C28H33ClN8O4
|
1
|
| 1 |
Ki = 979 nM
|
|
|
|
CP0439522
|
(2R,3R,4R)-2-(6-(3-Iodobenzylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C16H16IN5O3
|
1
|
| 1 |
Ki = 997 nM
|
|
|
|
CP0474768
|
1,3-Dimethyl-8-[3-methoxy-4-(2-pyrrolidin-4-ylethoxy)-phenyl]xanthine
Show/Hide
|
C20H25N5O4
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0433197
|
N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(1,3-oxazol-5-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C19H24N8O2
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0456799
|
N-[2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]benzamide
Show/Hide
|
C21H14N6O3
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0413677
|
(2R)-2-phenoxy-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0413680
|
2-(4-methoxyphenyl)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0435550
|
(2R)-2-(2-fluorophenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C17H15FN4O2
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0449536
|
(2R)-2-(3-chlorophenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C17H15ClN4O2
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0494052
|
N-[2-(furan-2-yl)-1,3-benzoxazol-5-yl]-2-piperidin-1-ylacetamide
Show/Hide
|
C18H19N3O3
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0250678
|
1-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea
Show/Hide
|
C27H24N8O3
|
1
|
| 1 |
Ki = 1015 nM
|
|
|
|
CP0446832
|
1,3-dimethyl-9-[(2-methylphenyl)methyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H21N5O2
|
1
|
| 1 |
Ki = 1020 nM
|
|
|
|
CP0198680
|
2-amino-8-(2-methylpyrazol-3-yl)-N-(quinolin-8-ylmethyl)quinazoline-4-carboxamide
Show/Hide
|
C23H19N7O
|
1
|
| 1 |
Ki = 1035 nM
|
|
|
|
CP0308558
|
1-(8-ethyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea
Show/Hide
|
C20H18N8O3
|
2
|
| 1 |
Ki = 1040 nM
|
|
|
| 2 |
Ki = 1045 nM
|
|
|
|
CP0495994
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carboxylic acid
Show/Hide
|
C20H28N4O4
|
1
|
| 1 |
Ki = 1070 nM
|
|
|
|
CP0401240
|
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(3-iodobenzylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
Show/Hide
|
C18H17ClIN5O2
|
1
|
| 1 |
Ki = 1080 nM
|
|
|
|
CP0386034
|
2-(4-isopentyl-2-oxo-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C28H31N3O3S
|
1
|
| 1 |
Ki = 1080 nM
|
|
|
|
CP0258611
|
(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H19IN6O3Se
|
1
|
| 1 |
Ki = 1080 nM
|
|
|
|
CP0393758
|
(2S,3S,4R,5R)-5-[6-(cyclobutylamino)purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C15H20N6O3Se
|
1
|
| 1 |
Ki = 1080 nM
|
|
|
|
CP0407841
|
3-ethyl-1-(2-methylpropyl)-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C22H23F3N6O2
|
1
|
| 1 |
Ki = 1090 nM
|
|
|
|
CP0258612
|
(2S,3S,4R,5R)-5-[6-(cyclopentylamino)purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C16H22N6O3Se
|
1
|
| 1 |
Ki = 1090 nM
|
|
|
|
CP0435443
|
8-[4-(2-Diethylaminoethoxy)-3-methoxyphenyl]-1,3-dimethylxanthine
Show/Hide
|
C20H27N5O4
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0382449
|
8-(1-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H24N8O3
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0378793
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-diisobutyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0528033
|
3-cyano-N-(3-(3-ethoxypropyl)-6-(morpholine-4-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C24H26N6O4
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0445406
|
N-(5-phenyl-1H-1,2,4-triazol-3-yl)butanamide
Show/Hide
|
C12H14N4O
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0441884
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(6-hydroxyhex-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C20H28N6O5
|
1
|
| 1 |
Ki = 1107 nM
|
|
|
|
CP0448162
|
(1S,2R,3S,4R,5S)-4-[2-azido-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C21H23N9O3
|
1
|
| 1 |
Ki = 1110 nM
|
|
|
|
CP0543075
|
(2S,3S,4R,5R)-5-[2-chloro-6-(cyclopentylamino)purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C16H21ClN6O3Se
|
1
|
| 1 |
Ki = 1120 nM
|
|
|
|
CP0248021
|
6-[(E)-2-(2-hydroxyphenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H17N3O3
|
1
|
| 1 |
Ki = 1144 nM
|
|
|
|
CP0547977
|
(2S,3S,4R,5R)-5-[6-[(2-chlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H19ClN6O3Se
|
1
|
| 1 |
Ki = 1160 nM
|
|
|
|
CP0427011
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(pyrazin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C18H19N9O5
|
1
|
| 1 |
Ki = 1170 nM
|
|
|
|
CP0465225
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(pyridin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C19H20N8O5
|
1
|
| 1 |
Ki = 1180 nM
|
|
|
|
CP0264646
|
1-(3-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13ClN8O2
|
1
|
| 1 |
Ki = 1195 nM
|
|
|
|
CP0372967
|
(1S,2R,3S,4R,5S)-4-(6-(5-chloro-2-methoxybenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C21H22Cl2N6O4
|
1
|
| 1 |
Ki = 1200 nM
|
|
|
|
CP0376121
|
8-(1-((5-(4-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H24ClN7O3
|
1
|
| 1 |
Ki = 1200 nM
|
|
|
|
CP0406723
|
1,3-dimethyl-8-(m-tolylamino)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C14H15N5O2
|
1
|
| 1 |
Ki = 1200 nM
|
|
|
|
CP0475949
|
(1S,2R,3S,4R,5S)-4-[6-amino-2-(2-phenylethynyl)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C21H20N6O3
|
1
|
| 1 |
Ki = 1200 nM
|
|
|
|
CP0258613
|
(2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H18ClIN6O3Se
|
1
|
| 1 |
Ki = 1200 nM
|
|
|
|
CP0468836
|
9-[(2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H18FN5O2
|
1
|
| 1 |
Ki = 1210 nM
|
|
|
|
CP0248931
|
1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]urea
Show/Hide
|
C20H17ClN8O2
|
2
|
| 1 |
Ki = 1220 nM
|
|
|
| 2 |
Ki = 1221 nM
|
|
|
|
CP0407843
|
3-ethyl-1-(2-methylpropyl)-8-(1H-pyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C14H18N6O2
|
1
|
| 1 |
Ki = 1220 nM
|
|
|
|
CP0533396
|
3-cyano-N-(3-(4-methoxybenzyl)-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C28H26N6O3
|
1
|
| 1 |
Ki = 1220 nM
|
|
|
|
CP0125603
|
(2S,3S,4R,5R)-5-[6-[(3-bromophenyl)methylamino]-2-chloropurin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H18BrClN6O3Se
|
1
|
| 1 |
Ki = 1230 nM
|
|
|
|
CP0527054
|
4-(4-fluorophenyl)-3-(2-hydroxyphenyl)-5-(2-methoxyethyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
Show/Hide
|
C20H18FN3O3
|
1
|
| 1 |
Ki = 1230.27 nM
|
|
|
|
CP0384628
|
4-[3-(8-methoxy-2,4-dioxo-3-propylpurino[7,8-a]pyridin-1-yl)propylcarbamoyl]benzenesulfonyl fluoride
Show/Hide
|
C23H24FN5O6S
|
1
|
| 1 |
Ki = 1258.93 nM
|
|
|
|
CP0484752
|
(2R,3R,4S)-2-(6-(3-Fluorobenzylamino)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol
Show/Hide
|
C16H16FN5O2S
|
1
|
| 1 |
Ki = 1260 nM
|
|
|
|
CP0456465
|
(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(2-methoxyphenyl)methylamino]purin-9-yl]-N-methylselenolane-2-carboxamide
Show/Hide
|
C19H22N6O4Se
|
1
|
| 1 |
Ki = 1260 nM
|
|
|
|
CP0425917
|
(1S,2R,3S,4R,5S)-4-[2-[2-(3-chlorophenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C22H21ClN6O3
|
1
|
| 1 |
Ki = 1270 nM
|
|
|
|
CP0168163
|
(E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-propenone
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0310622
|
(1S,2R,3S,4R,5S)-4-(6-(3-bromobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H20BrClN6O3
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0503948
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-diisobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H27FN6O2
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0301621
|
N-(4,6-dimethylpyrimidin-2-yl)-6-methyl-1H-benzimidazol-2-amine
Show/Hide
|
C14H15N5
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0477485
|
2-[(E)-[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]hydrazinylidene]methyl]benzonitrile
Show/Hide
|
C18H18N8O4
|
1
|
| 1 |
Ki = 1306 nM
|
|
|
|
CP0391611
|
(2S,3S,4R,5R)-5-[2-chloro-6-(2-methyl-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-thiophene-2-carboxylic acid methylamide
Show/Hide
|
C19H21ClN6O3S
|
1
|
| 1 |
Ki = 1320 nM
|
|
|
|
CP0444810
|
N-[4-[(E)-[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]hydrazinylidene]methyl]phenyl]acetamide
Show/Hide
|
C19H22N8O5
|
1
|
| 1 |
Ki = 1329 nM
|
|
|
|
CP0362925
|
(2R,3R,4S,5R)-2-[6-[[(1S,2S)-2-hydroxycyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C15H21N5O5
|
1
|
| 1 |
Ki = 1330 nM
|
|
|
|
CP0875487
|
2-((5-Chlorothiophen-2-yl)ethynyl)-N-methyl-9H-purin-6-amine
Show/Hide
|
C12H8ClN5S
|
1
|
| 1 |
Ki = 1330 nM
|
|
|
|
CP0921018
|
2-((5-Chlorothiophen-2-yl)ethynyl)-N-cyclopentyl-9H-purin-6-amine
Show/Hide
|
C16H14ClN5S
|
1
|
| 1 |
Ki = 1340 nM
|
|
|
|
CP0534305
|
(2R,3R,4S,5S)-2-[6-[[(1R,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol
Show/Hide
|
C17H22ClN5O3
|
1
|
| 1 |
Ki = 1340 nM
|
|
|
|
CP0383312
|
(1R,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-[2-(3,4-difluorophenyl)ethynyl]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C26H20ClF2N5O2
|
1
|
| 1 |
Ki = 1350 nM
|
|
|
|
CP0337685
|
(2S,3S,4R,5R)-5-[6-[(3-fluorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methylselenolane-2-carboxamide
Show/Hide
|
C18H19FN6O3Se
|
1
|
| 1 |
Ki = 1350 nM
|
|
|
|
CP0507803
|
4-[(5-naphthalen-2-yl-4-phenylpyrimidin-2-yl)amino]cyclohexan-1-ol
Show/Hide
|
C26H25N3O
|
1
|
| 1 |
Ki = 1389 nM
|
|
|
|
CP0282756
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea
Show/Hide
|
C19H16N8O3
|
1
|
| 1 |
Ki = 1390 nM
|
|
|
|
CP0407889
|
3-methyl-1-(2-methylpropyl)-8-(1H-pyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C13H16N6O2
|
1
|
| 1 |
Ki = 1390 nM
|
|
|
|
CP0428185
|
3-{[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carbonyl]-amino}-propionic acid methy lester
Show/Hide
|
C24H35N5O5
|
1
|
| 1 |
Ki = 1400 nM
|
|
|
|
CP0440683
|
1,3-Dimethyl-8-[3-(2-morpholin-4-ylethoxy)-phenyl]xanthine
Show/Hide
|
C19H23N5O4
|
1
|
| 1 |
Ki = 1400 nM
|
|
|
|
CP0378798
|
8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H22ClF3N6O2
|
1
|
| 1 |
Ki = 1400 nM
|
|
|
|
CP0456060
|
(2R,3R,4R)-2-(6-(3-Bromobenzylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C16H16BrN5O3
|
1
|
| 1 |
Ki = 1400 nM
|
|
|
|
CP0435553
|
(2R)-2-phenoxy-N-(5-phenyl-1H-1,2,4-triazol-3-yl)butanamide
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 1400 nM
|
|
|
|
CP0435274
|
1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C20H26N8O6
|
1
|
| 1 |
Ki = 1410 nM
|
|
|
|
CP0562184
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(6-methoxypyridin-3-yl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C17H20N8O5
|
1
|
| 1 |
Ki = 1449 nM
|
|
|
|
CP0386036
|
(S)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylpropyl)acetamide
Show/Hide
|
C31H29N3O3S
|
1
|
| 1 |
Ki = 1460 nM
|
|
|
|
CP0428515
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(pyridin-4-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C19H20N8O5
|
1
|
| 1 |
Ki = 1480 nM
|
|
|
|
CP0485837
|
N-(2-chlorophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]acetamide
Show/Hide
|
C22H24ClN7O3
|
1
|
| 1 |
Ki = 1500 nM
|
|
|
|
CP0894597
|
3-[4-(1,3-Bis-cyclohexylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylic acid
Show/Hide
|
C28H34N4O4
|
1
|
| 1 |
Ki = 1518 nM
|
|
|
|
CP0385206
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1S)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H26ClN5O3
|
1
|
| 1 |
Ki = 1520 nM
|
|
|
|
CP0401357
|
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(1-naphthylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
Show/Hide
|
C22H20ClN5O2
|
1
|
| 1 |
Ki = 1530 nM
|
|
|
|
CP0174710
|
2-amino-8-fluoro-N-[[4-(4-phenylpiperazine-1-carbonyl)quinolin-8-yl]methyl]quinazoline-4-carboxamide
Show/Hide
|
C30H26FN7O2
|
1
|
| 1 |
Ki = 1536 nM
|
|
|
|
CP0374399
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-(2-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
Ki = 1561 nM
|
|
|
|
CP0392277
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1R)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H24ClN5O2
|
1
|
| 1 |
Ki = 1570 nM
|
|
|
|
CP0139865
|
ethyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
Show/Hide
|
C21H26ClN5O4
|
1
|
| 1 |
Ki = 1570 nM
|
|
|
|
CP0446836
|
10-[(2,4-dichlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H19Cl2N5O2
|
1
|
| 1 |
Ki = 1580 nM
|
|
|
|
CP0851092
|
SID856593
Show/Hide
|
C14H11NO3S
|
1
|
| 1 |
Ki = 1584.89 nM
|
|
|
|
CP0880306
|
7-(2-(dimethylamino)ethoxy)-5-methyl-3-(4-methylthiazol-2-yl)-4H-chromen-4-one
Show/Hide
|
C18H20N2O3S
|
1
|
| 1 |
Ki = 1584.89 nM
|
|
|
|
CP0376939
|
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(3-Bromobenzylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
Show/Hide
|
C18H17BrClN5O2
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0447235
|
(2R,3R,4S)-2-(2-chloro-6-(2-chlorobenzylamino)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol
Show/Hide
|
C16H15Cl2N5O2S
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0169051
|
(1S,2R,3S,4R,5S)-4-(2-chloro-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C27H27ClN6O3
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0382446
|
8-(1-((3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0436221
|
6-[3-amino-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-2-yl]-2-N,2-N-dimethyl-1,3,5-triazine-2,4-diamine
Show/Hide
|
C15H19N7OS
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0081313
|
9-(5'-Cyclopropylmethylaminocarbonyl-4'-thio-beta-D-ribofuranosyl)-N6-(3-iodobenzyl)adenine
Show/Hide
|
C21H23IN6O3S
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0464128
|
N-[10-(2,2-difluoro-4,6,10,12-tetramethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)decyl]-2-[4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)phenoxy]acetamide
Show/Hide
|
C39H50BF2N7O4
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0420994
|
9-[(2-bromophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H18BrN5O2
|
1
|
| 1 |
Ki = 1610 nM
|
|
|
|
CP0493532
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3-ethoxy-4-hydroxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H23N7O6
|
1
|
| 1 |
Ki = 1622 nM
|
|
|
|
CP0371803
|
(1S,2R,3S,4R,5S)-6-(3-Chlorobenzylamino)-(2-(6-(1-(4-aminobutyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C32H39ClN10O3
|
1
|
| 1 |
Ki = 1630 nM
|
|
|
|
CP0390403
|
2,6-bis(furan-2-yl)imidazo[1,2-a]pyridine
Show/Hide
|
C15H10N2O2
|
1
|
| 1 |
Ki = 1630 nM
|
|
|
|
CP0161793
|
N-(4-bromophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C25H26BrN5O4
|
1
|
| 1 |
Ki = 1640 nM
|
|
|
|
CP0461202
|
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C16H20ClN5O2
|
1
|
| 1 |
Ki = 1640 nM
|
|
|
|
CP0428069
|
1,3-dipropyl-8-[2-(5,6-exo-epoxy-(1S,2S)-norborn-2-yl)]-xanthine
Show/Hide
|
C18H24N4O3
|
1
|
| 1 |
Ki = 1660 nM
|
|
|
|
CP0859355
|
3-[5-(2-methylimidazol-1-yl)-2-(pyrazin-2-ylamino)-1,3-thiazol-4-yl]benzonitrile
Show/Hide
|
C18H13N7S
|
1
|
| 1 |
Ki = 1670 nM
|
|
|
|
CP0475061
|
5-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid methoxy-amide
Show/Hide
|
C18H18ClIN6O5
|
1
|
| 1 |
Ki = 1670 nM
|
|
|
|
CP0497764
|
2-(4-cyanobenzamido)-N-(3-methoxybenzyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxamide
Show/Hide
|
C28H27N5O4
|
1
|
| 1 |
Ki = 1670 nM
|
|
|
|
CP0376108
|
1,3-dipropyl-8-(1-((5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H24F3N7O3
|
1
|
| 1 |
Ki = 1700 nM
|
|
|
|
CP0393290
|
2-(2-methylphenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
Ki = 1700 nM
|
|
|
|
CP0393291
|
2-(2,6-dimethylphenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 1700 nM
|
|
|
|
CP0460950
|
9-[(3-bromophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H18BrN5O2
|
1
|
| 1 |
Ki = 1700 nM
|
|
|
|
CP0457866
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C18H17FN6O2
|
1
|
| 1 |
Ki = 1730 nM
|
|
|
|
CP0432442
|
(1S,2R,3S,4R,5S)-4-[2-[2-(3-chlorophenyl)ethynyl]-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C28H24Cl2N6O3
|
1
|
| 1 |
Ki = 1740 nM
|
|
|
|
CP0423939
|
N-[2-(furan-2-yl)-5-oxo-4H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]benzamide
Show/Hide
|
C15H10N6O3
|
1
|
| 1 |
Ki = 1750 nM
|
|
|
|
CP0385204
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(pentan-3-ylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C17H24ClN5O3
|
1
|
| 1 |
Ki = 1750 nM
|
|
|
|
CP0204630
|
(1S,2R,3S,4R,5S)-4-(6-amino-2-chloropurin-9-yl)-1-(chloromethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C12H13Cl2N5O2
|
1
|
| 1 |
Ki = 1750 nM
|
|
|
|
CP0795220
|
US9227979, 3
Show/Hide
|
C36H29N9O6S
|
1
|
| 1 |
Ki = 1750 nM
|
|
|
|
CP0421548
|
(1R,2R,3S,4R,5S)-4-[6-(cyclopentylamino)-2-hex-1-ynylpurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C22H29N5O2
|
1
|
| 1 |
Ki = 1760 nM
|
|
|
|
CP0721793
|
SID857722
Show/Hide
|
C13H16N2O2S
|
1
|
| 1 |
Ki = 1778.28 nM
|
|
|
|
CP0435634
|
(2R,3R,4S,5R)-2-(6-(ethylamino)-2-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C20H22N8O4
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0376124
|
8-(1-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H24N8O3
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0392197
|
8-(1-((3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0416220
|
(1R,2R,3S,4R,5S)-4-[2-[2-(3-chlorophenyl)ethynyl]-6-[(3-chlorophenyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C26H21Cl2N5O2
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0435554
|
2-phenoxy-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C16H14N4O2
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0435557
|
(2R)-N-[5-(3-methylphenyl)-1H-1,2,4-triazol-3-yl]-2-phenoxypropanamide
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0498521
|
N-[2-(3,5-dimethylpyrazol-1-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C16H23N7O
|
1
|
| 1 |
Ki = 1867 nM
|
|
|
|
CP0155247
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1R)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H24ClN5O3
|
1
|
| 1 |
Ki = 1880 nM
|
|
|
|
CP0398047
|
(R)-N-(2-hydroxy-1-phenylethyl)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)acetamide
Show/Hide
|
C30H27N3O4S
|
1
|
| 1 |
Ki = 1925 nM
|
|
|
|
CP0421972
|
3-ethyl-8-[1-(1-oxidopyridin-1-ium-3-yl)pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C18H19N7O3
|
1
|
| 1 |
Ki = 1950 nM
|
|
|
|
CP0376073
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-iodo-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C14H19IN6O4
|
1
|
| 1 |
Ki = 1955 nM
|
|
|
|
CP0377525
|
N-(3,4-dimethyl-2,5-dioxopyrrol-1-yl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C25H28N6O6
|
1
|
| 1 |
Ki = 1970 nM
|
|
|
|
CP0953878
|
2-(5-methyl-7-phenyl-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
Show/Hide
|
C20H21N5O2
|
1
|
| 1 |
Ki = 1995.26 nM
|
|
|
|
CP0521867
|
2-[5-methyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxochromen-7-yl]oxyacetic acid
Show/Hide
|
C16H13NO5S
|
2
|
| 1 |
Ki = 1995.26 nM
|
|
|
| 2 |
Ki = 2238.72 nM
|
|
|
|
CP0908430
|
7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one
Show/Hide
|
C13H9NO3S
|
1
|
| 1 |
Ki = 1995.26 nM
|
|
|
|
CP0413676
|
N-[5-(3-methylphenyl)-1H-1,2,4-triazol-3-yl]-2-phenoxypropanamide
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 2000 nM
|
|
|
|
CP0497462
|
2-(3-methylphenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
Ki = 2000 nM
|
|
|
|
CP0114093
|
8-cyclopentyl-2-(2-methylpyridin-3-yl)oxy-1-propyl-7H-purin-6-one
Show/Hide
|
C19H23N5O2
|
1
|
| 1 |
Ki = 2000 nM
|
|
|
|
CP0401358
|
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(trans-2-phenylcyclopropylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
Show/Hide
|
C20H20ClN5O2
|
1
|
| 1 |
Ki = 2010 nM
|
|
|
|
CP0436205
|
3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thiazol-4-yl]-benzonitrile
Show/Hide
|
C17H11N7S
|
1
|
| 1 |
Ki = 2020 nM
|
|
|
|
CP0460955
|
1,3-dimethyl-9-(thiophen-2-ylmethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C15H17N5O2S
|
1
|
| 1 |
Ki = 2020 nM
|
|
|
|
CP0134329
|
9-(3-chlorobenzyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione
Show/Hide
|
C17H18ClN5O2
|
1
|
| 1 |
Ki = 2030 nM
|
|
|
|
CP0139866
|
(2R,3R,4S,5S)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol
Show/Hide
|
C17H22ClN5O3
|
1
|
| 1 |
Ki = 2050 nM
|
|
|
|
CP0432711
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R)-3-hydroxybut-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C18H24N6O5
|
1
|
| 1 |
Ki = 2130 nM
|
|
|
|
CP0392829
|
(2R,3R,4R)-2-(6-amino-2-hexylpurin-9-yl)oxolane-3,4-diol
Show/Hide
|
C15H23N5O3
|
1
|
| 1 |
Ki = 2160 nM
|
|
|
|
CP0392905
|
(2R)-2-phenylsulfanyl-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C17H16N4OS
|
1
|
| 1 |
Ki = 2200 nM
|
|
|
|
CP0388086
|
(1R,2R,3S,4R,5S)-4-[6-(cyclopropylamino)-2-hex-1-ynylpurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C20H25N5O2
|
1
|
| 1 |
Ki = 2200 nM
|
|
|
|
CP0067796
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H24ClN5O3
|
1
|
| 1 |
Ki = 2200 nM
|
|
|
|
CP0215226
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1R)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H26ClN5O3
|
1
|
| 1 |
Ki = 2200 nM
|
|
|
|
CP0445789
|
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-N-(cyclopropylmethyl)-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C21H22ClIN6O3S
|
1
|
| 1 |
Ki = 2220 nM
|
|
|
|
CP0476905
|
(1R,2R,3S,4R,5S)-4-[6-(dicyclopropylmethylamino)-2-iodopurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H22IN5O2
|
1
|
| 1 |
Ki = 2230 nM
|
|
|
|
CP0394495
|
3-ethyl-1-propyl-8-[1-[6-(trifluoromethyl)pyridin-3-yl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C19H18F3N7O2
|
1
|
| 1 |
Ki = 2250 nM
|
|
|
|
CP0467673
|
4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclohexanecarboxylic acid butylamide
Show/Hide
|
C22H35N5O3
|
1
|
| 1 |
Ki = 2260 nM
|
|
|
|
CP0077413
|
(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C15H20ClN5O4
|
1
|
| 1 |
Ki = 2270 nM
|
|
|
|
CP0436501
|
1-(cyclopropylmethyl)-3-ethyl-8-[1-[6-(trifluoromethyl)pyridin-3-yl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C20H18F3N7O2
|
1
|
| 1 |
Ki = 2280 nM
|
|
|
|
CP0169052
|
(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H20Cl2N6O3
|
1
|
| 1 |
Ki = 2300 nM
|
|
|
|
CP0397366
|
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-chlorobenzylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H20Cl2N6O3
|
1
|
| 1 |
Ki = 2300 nM
|
|
|
|
CP0708191
|
TECADENOSON
Show/Hide
|
C14H19N5O5
|
1
|
| 1 |
Ki = 2315 nM
|
|
|
|
CP0428481
|
(2R,3R,4S,5R)-2-(6-(p-toluidino)-2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C21H23N7O5
|
1
|
| 1 |
Ki = 2320 nM
|
|
|
|
CP0448382
|
2-[4-[2,6-dioxo-1,3-bis(prop-2-enyl)-7H-purin-8-yl]phenoxy]acetic acid
Show/Hide
|
C19H18N4O5
|
1
|
| 1 |
Ki = 2370 nM
|
|
|
|
CP0373150
|
3-ethyl-1-propyl-8-[1-[[5-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-yl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C24H22F3N7O3
|
1
|
| 1 |
Ki = 2370 nM
|
|
|
|
CP0883987
|
(R)-2-((5-Chlorothiophen-2-yl)ethynyl)-N-(tetrahydrofuran-3-yl)-9H-purin-6-amine
Show/Hide
|
C15H12ClN5OS
|
1
|
| 1 |
Ki = 2370 nM
|
|
|
|
CP0526300
|
2-(3-methoxybenzamido)-N-(3-methoxybenzyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxamide
Show/Hide
|
C28H30N4O5
|
1
|
| 1 |
Ki = 2380 nM
|
|
|
|
CP0487243
|
4-[amino-(2-chlorophenyl)methyl]-N-phthalazin-1-yl-1,3-thiazol-2-amine
Show/Hide
|
C18H14ClN5S
|
1
|
| 1 |
Ki = 2398.83 nM
|
|
|
|
CP0449467
|
ethyl 1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
|
C20H25N7O7
|
1
|
| 1 |
Ki = 2410 nM
|
|
|
|
CP0497768
|
2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-imidazo[4,5-b]pyridine-6-carboxamide
Show/Hide
|
C19H18N6O3
|
1
|
| 1 |
Ki = 2430 nM
|
|
|
|
CP0442091
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-4-hydroxypent-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C19H26N6O5
|
1
|
| 1 |
Ki = 2433 nM
|
|
|
|
CP0398046
|
(S)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylethyl)acetamide
Show/Hide
|
C30H27N3O3S
|
1
|
| 1 |
Ki = 2439 nM
|
|
|
|
CP0421792
|
(1S,2R,3S,4R,5S)-6-(3-Chlorobenzylamino)-(2-(6-(1-(4-acetamidoethyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C32H37ClN10O4
|
1
|
| 1 |
Ki = 2440 nM
|
|
|
|
CP0482877
|
(1R,2R,3S,4R,5S)-4-[6-[[(1S,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H22ClN5O2
|
1
|
| 1 |
Ki = 2450 nM
|
|
|
|
CP0551693
|
(2S,3S,4R,5R)-5-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Show/Hide
|
C20H21FN6O4S
|
1
|
| 1 |
Ki = 2460 nM
|
|
|
|
CP0386868
|
(2S,3S,4R,5R)-3,4-dihydroxy-N-methyl-5-[6-[[(1R,2S)-2-phenylcyclopropyl]amino]purin-9-yl]selenolane-2-carboxamide
Show/Hide
|
C20H22N6O3Se
|
1
|
| 1 |
Ki = 2480 nM
|
|
|
|
CP0806596
|
US9227979, 1
Show/Hide
|
C32H21N9O6S
|
1
|
| 1 |
Ki = 2480 nM
|
|
|
|
CP0435426
|
2-[2-(4-Benzooxazol-2-yl-pyrazol-1-yl)-6-methylamino-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C21H20N8O5
|
1
|
| 1 |
Ki = 2500 nM
|
|
|
|
CP0373145
|
3-ethyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C20H21FN6O2
|
1
|
| 1 |
Ki = 2500 nM
|
|
|
|
CP0422176
|
8-(1-((3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 2500 nM
|
|
|
|
CP0436646
|
8-(1-((5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 2500 nM
|
|
|
|
CP0392903
|
N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C11H12N4O
|
1
|
| 1 |
Ki = 2500 nM
|
|
|
|
CP0395292
|
(1R,2R,3S,4R,5S)-4-[2-hex-1-ynyl-6-[(3-iodophenyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C24H26IN5O2
|
1
|
| 1 |
Ki = 2530 nM
|
|
|
|
CP0488385
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[(2-phenylcyclopropyl)amino]-2-(2-phenylethynyl)purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C27H25N5O4
|
1
|
| 1 |
Ki = 2530 nM
|
|
|
|
CP0397632
|
2-[4-(1,3-dibutyl-2,6-dioxo-7H-purin-8-yl)phenoxy]acetic acid
Show/Hide
|
C21H26N4O5
|
1
|
| 1 |
Ki = 2540 nM
|
|
|
|
CP0413882
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1S)-1,2-dicyclopropylethyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H24ClN5O2
|
1
|
| 1 |
Ki = 2550 nM
|
|
|
|
CP0139864
|
(2R,3R,4S,5R)-2-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H26ClN5O4
|
1
|
| 1 |
Ki = 2550 nM
|
|
|
|
CP0446413
|
3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thiazol-4-yl]-benzonitrile
Show/Hide
|
C17H11N7S
|
1
|
| 1 |
Ki = 2570 nM
|
|
|
|
CP0511562
|
3-(2-(cyclopropylamino)-7-(2-methoxybenzyl)-8-oxo-7H-purin-9(8H)-yl)benzonitrile
Show/Hide
|
C23H20N6O2
|
1
|
| 1 |
Ki = 2587 nM
|
|
|
|
CP0524113
|
3-cyano-N-(3-(4-fluorobenzyl)-6-(piperidine-1-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C27H23FN6O2
|
1
|
| 1 |
Ki = 2590 nM
|
|
|
|
CP0372810
|
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(2,5-dimethoxybenzylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
Show/Hide
|
C20H22ClN5O4
|
1
|
| 1 |
Ki = 2620 nM
|
|
|
|
CP0474809
|
2-(cyclopropylamino)-9-(3-methoxyphenyl)-7-methyl-7H-purin-8(9H)-one
Show/Hide
|
C16H17N5O2
|
1
|
| 1 |
Ki = 2641 nM
|
|
|
|
CP0067797
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(S)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C20H26ClN5O3
|
1
|
| 1 |
Ki = 2690 nM
|
|
|
|
CP0435442
|
1,3-Dimethyl-8-[4-methoxy-3-(2-piperidin-1-ylethoxy)-phenyl]xanthine
Show/Hide
|
C21H27N5O4
|
1
|
| 1 |
Ki = 2700 nM
|
|
|
|
CP0401283
|
3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4-yl]-benzonitrile
Show/Hide
|
C18H12N6S
|
1
|
| 1 |
Ki = 2700 nM
|
|
|
|
CP0915991
|
3-[5-Imidazol-1-yl-2-(3-methyl-pyridin-2-ylamino)-thiazol-4-yl]-benzonitrile
Show/Hide
|
C19H14N6S
|
1
|
| 1 |
Ki = 2700 nM
|
|
|
|
CP0376110
|
8-(1-((5-(2-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H24ClN7O3
|
1
|
| 1 |
Ki = 2700 nM
|
|
|
|
CP0332246
|
2-amino-7-methoxy-4-(pyridin-4-yl)dibenzo[b,d]furan-1,3-dicarbonitrile
Show/Hide
|
C20H12N4O2
|
1
|
| 1 |
Ki = 2700 nM
|
|
|
|
CP0408805
|
8-(4-benzyloxymethyl-cyclohexyl)-1,3-dipropyl-3,7-dihydropurine-2,6-dione
Show/Hide
|
C25H34N4O3
|
1
|
| 1 |
Ki = 2720 nM
|
|
|
|
CP0441349
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(cyclohexylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C17H22ClN5O2
|
1
|
| 1 |
Ki = 2720 nM
|
|
|
|
CP0457597
|
8-(1-benzyl-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H18N6O2
|
1
|
| 1 |
Ki = 2760 nM
|
|
|
|
CP0455646
|
(2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin-9-yl)-N-cyclopropyl-3,4-dihydroxy-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C14H17ClN6O3S
|
1
|
| 1 |
Ki = 2770 nM
|
|
|
|
CP0429757
|
(1S,2R,3S,4R,5S)-4-[2-azido-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H20ClN9O3
|
1
|
| 1 |
Ki = 2770 nM
|
|
|
|
CP0495407
|
(2-(benzyl(methyl)amino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C22H18N2O2S
|
1
|
| 1 |
Ki = 2798 nM
|
|
|
|
CP0435555
|
4-chloro-N-(5-phenyl-1H-1,2,4-triazol-3-yl)benzamide
Show/Hide
|
C15H11ClN4O
|
1
|
| 1 |
Ki = 2800 nM
|
|
|
|
CP0386041
|
2-(3-(3-methylisoxazol-5-yl)-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C32H31N3O4
|
1
|
| 1 |
Ki = 2832 nM
|
|
|
|
CP0433444
|
(1R,2R,3S,4R,5S)-4-[6-(ethylamino)-2-hex-1-ynylpurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H25N5O2
|
1
|
| 1 |
Ki = 2860 nM
|
|
|
|
CP0432814
|
8-[3-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H27F3N6O5
|
1
|
| 1 |
Ki = 2900 nM
|
|
|
|
CP0385205
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1S)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H24ClN5O3
|
1
|
| 1 |
Ki = 2950 nM
|
|
|
|
CP0439094
|
2-[[1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carbonyl]amino]-3-phenylpropanoic acid
Show/Hide
|
C21H22N2O5
|
1
|
| 1 |
Ki = 2951.21 nM
|
|
|
|
CP0441852
|
benzyl N-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)cyclohexyl]carbamate
Show/Hide
|
C25H33N5O4
|
1
|
| 1 |
Ki = 2960 nM
|
|
|
|
CP0422193
|
1,3-dipropyl-8-(1-((3-p-tolyl-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O3
|
1
|
| 1 |
Ki = 3000 nM
|
|
|
|
CP0441351
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(cyclobutylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C15H18ClN5O2
|
1
|
| 1 |
Ki = 3020 nM
|
|
|
|
CP0460957
|
1,3-dimethyl-9-(2-pyridin-3-ylethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H20N6O2
|
1
|
| 1 |
Ki = 3040 nM
|
|
|
|
CP0443759
|
4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzoic acid methyl ester
Show/Hide
|
C27H29N5O6
|
1
|
| 1 |
Ki = 3100 nM
|
|
|
|
CP0423201
|
(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-(2-pyren-1-ylethynyl)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C38H29ClN6O3
|
1
|
| 1 |
Ki = 3110 nM
|
|
|
|
CP0183628
|
(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (2-amino-ethyl)-amide
Show/Hide
|
C12H17N7O4
|
1
|
| 1 |
Ki = 3120 nM
|
|
|
|
CP0392280
|
(1R,2R,3S,4R,5S)-4-(6-amino-2-chloropurin-9-yl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C11H12ClN5O2
|
1
|
| 1 |
Ki = 3140 nM
|
|
|
|
CP0911227
|
(2-Cyclopentyl-1H-imidazo[4,5-c]quinolin-4-yl)-phenyl-amine
Show/Hide
|
C21H20N4
|
1
|
| 1 |
Ki = 3150 nM
|
|
|
|
CP0388087
|
(1R,2R,3S,4R,5S)-4-[6-[(3-bromophenyl)methylamino]-2-hex-1-ynylpurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C24H26BrN5O2
|
1
|
| 1 |
Ki = 3150 nM
|
|
|
|
CP0453336
|
2-(3,5-dimethylphenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 3200 nM
|
|
|
|
CP0921017
|
N-(Dicyclopropylmethyl)-2-(prop-1-yn-1-yl)-9H-purin-6-amine
Show/Hide
|
C15H17N5
|
1
|
| 1 |
Ki = 3240 nM
|
|
|
|
CP0378926
|
(1S,2R,3S,4R,5S)-4-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C18H23ClN6O3
|
1
|
| 1 |
Ki = 3250 nM
|
|
|
|
CP0174939
|
3-ethyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H21F3N6O2
|
1
|
| 1 |
Ki = 3280 nM
|
|
|
|
CP0418028
|
(1S,2R,3S,4R,5S)-6-(3-Chlorobenzylamino)-(2-(6-(1-(adamantyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C38H44ClN9O3
|
1
|
| 1 |
Ki = 3280 nM
|
|
|
|
CP0483399
|
[4-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-2-nitrophenyl] 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
Show/Hide
|
C39H47N11O10S
|
1
|
| 1 |
Ki = 3280 nM
|
|
|
|
CP0372682
|
2-Hydroxymethyl-5-{2-[4-(4-methoxy-phenyl)-pyrazol-1-yl]-6-propylamino-purin-9-yl}-tetrahydro-furan-3,4-diol
Show/Hide
|
C23H27N7O5
|
1
|
| 1 |
Ki = 3300 nM
|
|
|
|
CP0497773
|
3-cyano-N-(3-(2-ethoxyethyl)-6-(morpholine-4-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C23H24N6O4
|
1
|
| 1 |
Ki = 3300 nM
|
|
|
|
CP0388085
|
(1R,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-hex-1-ynylpurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C24H26ClN5O2
|
1
|
| 1 |
Ki = 3310 nM
|
|
|
|
CP0386541
|
(E)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-acrylic acid
Show/Hide
|
C22H30N4O4
|
1
|
| 1 |
Ki = 3330 nM
|
|
|
|
CP0471144
|
8-(1-benzyl-1H-pyrazol-4-yl)-1-butyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki = 3400 nM
|
|
|
|
CP0436674
|
8-(1-((5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 3400 nM
|
|
|
|
CP0413678
|
3-phenyl-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C17H16N4O
|
1
|
| 1 |
Ki = 3400 nM
|
|
|
|
CP0439521
|
(2R,3R,4R)-2-(6-(3-Chlorobenzylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C16H16ClN5O3
|
1
|
| 1 |
Ki = 3410 nM
|
|
|
|
CP0378795
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-dimethyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C17H16N6O2
|
1
|
| 1 |
Ki = 3500 nM
|
|
|
|
CP0435551
|
N-[5-(4-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenoxyacetamide
Show/Hide
|
C16H13FN4O2
|
1
|
| 1 |
Ki = 3500 nM
|
|
|
|
CP0380534
|
N-benzyl-2-[[2-oxo-4-(2-phenylethyl)-3-(1,3-thiazol-2-yl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C29H25N3O3S
|
1
|
| 1 |
Ki = 3509 nM
|
|
|
|
CP0461222
|
(1'S, 2'R, 3'S, 4'S, 5'S)-4'-[6-(3-Chlorobenzylamino)-2-(6-methoxycarbonyl)-1-hexynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C28H31ClN6O5
|
1
|
| 1 |
Ki = 3540 nM
|
|
|
|
CP0204638
|
(2R,3R,4S,5R)-2-[6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H27N5O4
|
1
|
| 1 |
Ki = 3550 nM
|
|
|
|
CP0549783
|
N-[4-(3-fluoro-5-methylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
|
C21H15FN4OS
|
1
|
| 1 |
Ki = 3550 nM
|
|
|
|
CP0877796
|
3-[2-(Pyrazin-2-ylamino)-5-[1,2,4]triazol-1-yl-thiazol-4-yl]-benzonitrile
Show/Hide
|
C16H10N8S
|
1
|
| 1 |
Ki = 3580 nM
|
|
|
|
CP0406724
|
6-(3,4-dimethoxyphenyl)-2-(phenylamino)pyrimidin-4(3H)-one
Show/Hide
|
C18H17N3O3
|
1
|
| 1 |
Ki = 3600 nM
|
|
|
|
CP0488506
|
N-[5-(4-methylphenyl)-1H-1,2,4-triazol-3-yl]-2-phenoxyacetamide
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
Ki = 3600 nM
|
|
|
|
CP0486922
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1R)-1-cyclopropylpropyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C17H22ClN5O2
|
1
|
| 1 |
Ki = 3610 nM
|
|
|
|
CP0456061
|
(2R,3R,4R)-2-(2-Chloro-6-(3-chlorobenzylamino)-9Hpurin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C16H15Cl2N5O3
|
1
|
| 1 |
Ki = 3630 nM
|
|
|
|
CP0392279
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1S)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H24ClN5O2
|
1
|
| 1 |
Ki = 3650 nM
|
|
|
|
CP0433494
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(pentan-3-ylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C16H22ClN5O2
|
1
|
| 1 |
Ki = 3700 nM
|
|
|
|
CP0436253
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(cyclopropylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C14H16ClN5O2
|
1
|
| 1 |
Ki = 3700 nM
|
|
|
|
CP0495462
|
(2R,3R,4S)-2-[6-[(3-chlorophenyl)methylamino]-2-hex-1-ynylpurin-9-yl]thiolane-3,4-diol
Show/Hide
|
C22H24ClN5O2S
|
1
|
| 1 |
Ki = 3730 nM
|
|
|
|
CP0373151
|
8-[1-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]pyrazol-4-yl]-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C22H21ClN8O3
|
1
|
| 1 |
Ki = 3780 nM
|
|
|
|
CP0381593
|
(R,S)-3-(3-(6-(ethylamino)-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1-hydroxyprop-2-ynyl)benzoic acid
Show/Hide
|
C24H26N6O7
|
1
|
| 1 |
Ki = 3783 nM
|
|
|
|
CP0372916
|
8-(1-benzyl-1H-pyrazol-4-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C17H16N6O2
|
1
|
| 1 |
Ki = 3800 nM
|
|
|
|
CP0507906
|
3-ethyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-1-(2-methylpropyl)-7H-purine-2,6-dione
Show/Hide
|
C21H23FN6O2
|
1
|
| 1 |
Ki = 3850 nM
|
|
|
|
CP0445790
|
(2S,3S,4R,5R)-5-[2-chloro-6-(2-methyl-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-thiophene-2-carboxylic acid cyclopropylmethyl-amide
Show/Hide
|
C22H25ClN6O3S
|
1
|
| 1 |
Ki = 3890 nM
|
|
|
|
CP0435556
|
2-(2,3-dihydro-1H-inden-5-yloxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C19H18N4O2
|
1
|
| 1 |
Ki = 3900 nM
|
|
|
|
CP0441238
|
(2R,3R,4S)-2-[6-[(3-bromophenyl)methylamino]-2-hex-1-ynylpurin-9-yl]thiolane-3,4-diol
Show/Hide
|
C22H24BrN5O2S
|
1
|
| 1 |
Ki = 3910 nM
|
|
|
|
CP0460419
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(cycloheptylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H24ClN5O2
|
1
|
| 1 |
Ki = 3930 nM
|
|
|
|
CP0307298
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(R)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C20H26ClN5O3
|
1
|
| 1 |
Ki = 3940 nM
|
|
|
|
CP0169100
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H22ClN5O2
|
1
|
| 1 |
Ki = 3950 nM
|
|
|
|
CP0372680
|
(2R,3R,4S,5R)-2-(6-(ethylamino)-2-(4-(4-methoxyphenyl)-1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C22H25N7O5
|
1
|
| 1 |
Ki = 4000 nM
|
|
|
|
CP0372683
|
2-Hydroxymethyl-5-{6-(3-iodo-benzylamino)-2-[4-(4-methoxy-phenyl)-pyrazol-1-yl]-purin-9-yl}-tetrahydro-furan-3,4-diol
Show/Hide
|
C27H26IN7O5
|
1
|
| 1 |
Ki = 4000 nM
|
|
|
|
CP0430087
|
1-[9-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-methylamino-9H-purin-2-yl]-1H-pyrazole-4-carboxylic acid 4-chloro-benzylamide
Show/Hide
|
C22H23ClN8O5
|
1
|
| 1 |
Ki = 4000 nM
|
|
|
|
CP0461219
|
(1R,2R,3S,4R,5S)-4-(2-fluoro-6-(3-iodobenzylamino)-9H-purin-9-yl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H17FIN5O2
|
1
|
| 1 |
Ki = 4000 nM
|
|
|
|
CP0435549
|
(2R)-2-(4-chlorophenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C17H15ClN4O2
|
1
|
| 1 |
Ki = 4000 nM
|
|
|
|
CP0440389
|
(2R,3R,4S)-2-(2-chloro-6-(5-chloro-2-methoxybenzylamino)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol
Show/Hide
|
C17H17Cl2N5O3S
|
1
|
| 1 |
Ki = 4020 nM
|
|
|
|
CP0460422
|
(1R,2R,3S,4R,5S)-4-[6-[[(1S,2R,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H22ClN5O2
|
1
|
| 1 |
Ki = 4080 nM
|
|
|
|
CP0485139
|
2-Hydroxymethyl-5-[6-methylamino-2-(4-pyridin-3-yl-pyrazol-1-yl)-purin-9-yl]-tetrahydro-furan-3,4-diol
Show/Hide
|
C19H20N8O4
|
1
|
| 1 |
Ki = 4100 nM
|
|
|
|
CP0395703
|
methyl 1-[6-(dicyclopropylmethylamino)-9-[(1S,2R,3S,4R,5R)-3,4-dihydroxy-2-bicyclo[3.1.0]hexanyl]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
|
C23H27N7O4
|
1
|
| 1 |
Ki = 4110 nM
|
|
|
|
CP0436021
|
3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thiazol-4-yl]-benzonitrile
Show/Hide
|
C17H11N7S
|
1
|
| 1 |
Ki = 4160 nM
|
|
|
|
CP0169097
|
(1R,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H24ClN5O3
|
1
|
| 1 |
Ki = 4260 nM
|
|
|
|
CP0378792
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-diisobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H27F3N6O2
|
1
|
| 1 |
Ki = 4300 nM
|
|
|
|
CP0155461
|
(1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H25ClN6O3
|
1
|
| 1 |
Ki = 4320 nM
|
|
|
|
CP0371799
|
(1'S,2'R,3'S,4'R,5'S)-4'-[6-(3-Chlorobenzylamino)-2-(1,6-heptadiynyl)-9H-purin-9-yl]-2',3'-dihydroxybicyclo[3.1.0]-hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C27H27ClN6O3
|
1
|
| 1 |
Ki = 4330 nM
|
|
|
|
CP0385405
|
tert-butyl N-[2-[[2-(furan-2-yl)-5-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino]ethyl]carbamate
Show/Hide
|
C22H33N9O5
|
1
|
| 1 |
Ki = 4360 nM
|
|
|
|
CP0482878
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(cyclopropylmethylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C15H18ClN5O2
|
1
|
| 1 |
Ki = 4410 nM
|
|
|
|
CP0372968
|
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(3-chlorobenzylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
Show/Hide
|
C18H17Cl2N5O2
|
2
|
| 1 |
Ki = 4510 nM
|
|
|
| 2 |
Ki = 4520 nM
|
|
|
|
CP0376938
|
(1R,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-9H-purin-9-yl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H18ClN5O2
|
1
|
| 1 |
Ki = 4520 nM
|
|
|
|
CP0401247
|
(1R,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-9H-purin-9-yl)bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H18IN5O2
|
1
|
| 1 |
Ki = 4520 nM
|
|
|
|
CP0551692
|
(1S,2R,3S,4R,5S)-4-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H19FN6O3S
|
1
|
| 1 |
Ki = 4620 nM
|
|
|
|
CP0542394
|
4-(4-fluorobenzoyl)-N-(3-imidazol-1-ylpropyl)-1H-pyrrole-2-carboxamide
Show/Hide
|
C18H17FN4O2
|
1
|
| 1 |
Ki = 4677.35 nM
|
|
|
|
CP0526301
|
2-(2-chlorobenzamido)-N-(3-methoxybenzyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxamide
Show/Hide
|
C27H27ClN4O4
|
1
|
| 1 |
Ki = 4710 nM
|
|
|
|
CP0397193
|
(1'S,2'R,3'S,4'S,5'S)-4'-[6-(3-Chlorobenzylamino)-2-(N-cyanine(beta-aminoethylaminocarbonyl)-1-butynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic Acid N-Methylamide
Show/Hide
|
C60H69ClN10O8S
|
1
|
| 1 |
Ki = 4730 nM
|
|
|
|
CP0371797
|
1-(6-(2-(5-(6-(3-chlorobenzylamino)-9-((1S,2R,3S,4R,5S)-3,4-dihydroxy-5-(methylcarbamoyl)bicyclo[3.1.0]hexan-2-yl)-9H-purin-2-yl)pent-4-ynamido)ethylamino)-6-oxohexyl)-2-(5-(1-ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dienyl)-3,3-dimethyl-3H-indolium-5-sulfonate
Show/Hide
|
C60H69ClN10O11S2
|
1
|
| 1 |
Ki = 4730 nM
|
|
|
|
CP0475075
|
5-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid methyl ester
Show/Hide
|
C18H17ClIN5O5
|
1
|
| 1 |
Ki = 4770 nM
|
|
|
|
CP0161397
|
(1S,2R,3S,4R,5S)-4-(2-chloro-6-(2-phenylcyclopropylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C22H23ClN6O3
|
1
|
| 1 |
Ki = 4800 nM
|
|
|
|
CP0453459
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1R)-1,2-dicyclopropylethyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H24ClN5O2
|
1
|
| 1 |
Ki = 4840 nM
|
|
|
|
CP0490799
|
(2S,3S,4R,5R)-5-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyl-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C14H17ClN6O3S
|
1
|
| 1 |
Ki = 4890 nM
|
|
|
|
CP0396067
|
(2R,3R,4S)-2-[2-hex-1-ynyl-6-[(3-iodophenyl)methylamino]purin-9-yl]thiolane-3,4-diol
Show/Hide
|
C22H24IN5O2S
|
1
|
| 1 |
Ki = 4890 nM
|
|
|
|
CP0445291
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1S)-1-cyclopropylpropyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C17H22ClN5O2
|
1
|
| 1 |
Ki = 4910 nM
|
|
|
|
CP0408095
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(4-methoxyphenyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H26N6O5
|
1
|
| 1 |
Ki = 4963 nM
|
|
|
|
CP0482066
|
2-phenylmethoxy-N-(5-phenyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
Ki = 5000 nM
|
|
|
|
CP0453614
|
N-[3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-2-phenylacetamide
Show/Hide
|
C15H11N5O2S
|
1
|
| 1 |
Ki = 5100 nM
|
|
|
|
CP0374400
|
2-(cyclopropylamino)-7-(2-methoxyphenyl)-9-(3-methoxyphenyl)-7H-purin-8(9H)-one
Show/Hide
|
C22H21N5O3
|
1
|
| 1 |
Ki = 5122 nM
|
|
|
|
CP0057624
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)-N-(4-iodophenyl)acetamide
Show/Hide
|
C25H26IN5O4
|
1
|
| 1 |
Ki = 5140 nM
|
|
|
|
CP0169090
|
(2S,3S,4R,5R)-2-(chloromethyl)-5-[6-[di(cyclobutyl)methylamino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C19H26ClN5O3
|
1
|
| 1 |
Ki = 5200 nM
|
|
|
|
CP0854852
|
N-(4-methyl-phenyl)-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C22H22N4
|
1
|
| 1 |
Ki = 5220 nM
|
|
|
|
CP0425916
|
(1S,2R,3S,4R,5S)-4-[2-[2-(4-acetylphenyl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C24H24N6O4
|
1
|
| 1 |
Ki = 5300 nM
|
|
|
|
CP0017043
|
(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Show/Hide
|
C18H18ClIN6O4
|
3
|
| 1 |
Ki = 5360 nM
|
|
|
| 2 |
Ki = 5370 nM
|
|
|
| 3 |
Ki = 5400 nM
|
|
|
|
CP0440591
|
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-(2-hydroxyethyl)bicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C21H27ClN6O4
|
1
|
| 1 |
Ki = 5400 nM
|
|
|
|
CP0407893
|
3-ethyl-1-(2-methylpropyl)-8-[1-[6-(trifluoromethyl)pyridin-3-yl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C20H20F3N7O2
|
1
|
| 1 |
Ki = 5410 nM
|
|
|
|
CP0392276
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(R)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H24ClN5O2
|
1
|
| 1 |
Ki = 5470 nM
|
|
|
|
CP0371792
|
(1S,2R,3S,4R,5S)-4'-(6-(3-Chlorobenzylamino)-2-(6-(1-(4-amino-phenyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C34H35ClN10O3
|
1
|
| 1 |
Ki = 5490 nM
|
|
|
|
CP0518342
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(3,4,5-trimethoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C20H25N7O7
|
1
|
| 1 |
Ki = 5495 nM
|
|
|
|
CP0914847
|
4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-ylcarbamate
Show/Hide
|
C13H8N6O2S
|
1
|
| 1 |
Ki = 5610 nM
|
|
|
|
CP0371802
|
(1S,2R,3S,4R,5S)-6-(3-Chlorobenzylamino)-4-(2-(6-(4-(2-bromoacetyl)phenyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C36H35BrClN9O4
|
1
|
| 1 |
Ki = 5740 nM
|
|
|
|
CP0418019
|
(1R,2R,3S,4R,5S)-4-[2-[2-(2-fluorophenyl)ethynyl]-6-[2-(4-hydroxy-3-methoxyphenyl)ethylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C28H26FN5O4
|
1
|
| 1 |
Ki = 5850 nM
|
|
|
|
CP0510317
|
(2-(1H-indol-3-yl)ethylamino)(pyrimidin-2-ylamino)methaniminium
Show/Hide
|
C15H16N6
|
1
|
| 1 |
Ki = 5900 nM
|
|
|
|
CP0413679
|
N-(5-phenyl-1H-1,2,4-triazol-3-yl)oxolane-2-carboxamide
Show/Hide
|
C13H14N4O2
|
1
|
| 1 |
Ki = 5900 nM
|
|
|
|
CP0902331
|
5-(3-(3-(2-(2-(3-((2-(Furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e]-[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)amino)propoxy)ethoxy)-ethoxy)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid
Show/Hide
|
C42H41N9O9S
|
1
|
| 1 |
Ki = 6010 nM
|
|
|
|
CP0458904
|
(1R,2R,3S,4R,5S)-2,3-dihydroxy-4-(6-(3-iodobenzylamino)-9H-purin-9-yl)-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H21IN6O3
|
1
|
| 1 |
Ki = 6200 nM
|
|
|
|
CP0382247
|
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[6-(3-iodo-benzylamino)-purin-9-yl]-bicyclo[3.1.0]hexane-1-carboxylic acid methylamide
Show/Hide
|
C20H21IN6O3
|
1
|
| 1 |
Ki = 6200 nM
|
|
|
|
CP0455810
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[2,4-bis(trifluoromethyl)phenyl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C19H17F6N7O4
|
1
|
| 1 |
Ki = 6276 nM
|
|
|
|
CP0384355
|
N-[3-(8-methoxy-2,4-dioxo-3-propylpurino[7,8-a]pyridin-1-yl)propyl]-4-methylsulfonylbenzamide
Show/Hide
|
C24H27N5O6S
|
1
|
| 1 |
Ki = 6309.57 nM
|
|
|
|
CP0392899
|
(2R)-2-(4-methylphenoxy)-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 6400 nM
|
|
|
|
CP0499917
|
3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-propionic acid
Show/Hide
|
C22H32N4O4
|
1
|
| 1 |
Ki = 6410 nM
|
|
|
|
CP0449679
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(S)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H24ClN5O2
|
1
|
| 1 |
Ki = 6450 nM
|
|
|
|
CP0427461
|
(2R,3R,4R)-2-(6-(3-Fluorobenzylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
Show/Hide
|
C16H16FN5O3
|
1
|
| 1 |
Ki = 6560 nM
|
|
|
|
CP0538071
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-pyrrolidin-1-ylphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H26N8O4
|
1
|
| 1 |
Ki = 6625 nM
|
|
|
|
CP0459773
|
(2S,3S,4R,5R)-5-(2-(2-cyclohexenylethynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H28N6O4
|
1
|
| 1 |
Ki = 6707 nM
|
|
|
|
CP0371804
|
(1S,2R,3S,4R,5S)-4'-(6-(3-Chlorobenzylamino)-2-(6-(1-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C34H33ClN10O5
|
1
|
| 1 |
Ki = 6730 nM
|
|
|
|
CP0521991
|
2-amino-N-(3-methoxybenzyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxamide
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
Ki = 6770 nM
|
|
|
|
CP0462676
|
(2-(dimethylamino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C16H14N2O2S
|
1
|
| 1 |
Ki = 6818 nM
|
|
|
|
CP0476396
|
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(2-hydroxy-5-methoxybenzylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
Show/Hide
|
C19H20ClN5O4
|
1
|
| 1 |
Ki = 6870 nM
|
|
|
|
CP0501472
|
(1'S,2'R,3'S,4'R,5'S)-4'-[6-(3-Chlorobenzylamino)-2-(1,7-octadiynyl)-9H-purin-9-yl]-2',3'-dihydroxybicyclo[3.1.0]-hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C28H29ClN6O3
|
1
|
| 1 |
Ki = 7040 nM
|
|
|
|
CP0946355
|
(1S,2S)-2-((2-((5-Chlorothiophen-2-yl)ethynyl)-9H-purin-6-yl)amino)cyclopentan-1-ol
Show/Hide
|
C16H14ClN5OS
|
1
|
| 1 |
Ki = 7070 nM
|
|
|
|
CP0931911
|
5-(3-aminobenzyl)thiazolidine-2,4-dione
Show/Hide
|
C10H10N2O2S
|
1
|
| 1 |
Ki = 7079.46 nM
|
|
|
|
CP0462677
|
(2-(benzyl(2-(thiophen-2-yl)ethyl)amino)-4-(furan-2-yl)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C27H22N2O2S2
|
1
|
| 1 |
Ki = 7140 nM
|
|
|
|
CP0371801
|
(1S,2R,3S,4R,5S)-6-(3-Chlorobenzylamino)-(2-(6-(1-(4-acetamidobutyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
Show/Hide
|
C34H41ClN10O4
|
1
|
| 1 |
Ki = 7240 nM
|
|
|
|
CP0381591
|
(2S,3S,4R,5R)-5-(2-(2-(1-aminocyclohexyl)ethynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H31N7O4
|
1
|
| 1 |
Ki = 7350 nM
|
|
|
|
CP0395291
|
(1R,2R,3S,4R,5S)-4-[2-hex-1-ynyl-6-(methylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C18H23N5O2
|
1
|
| 1 |
Ki = 7490 nM
|
|
|
|
CP0424126
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[(4,5-difluoro-2-methoxyphenyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H18ClF2N5O3
|
1
|
| 1 |
Ki = 7510 nM
|
|
|
|
CP0463076
|
[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-naphthalen-1-ylmethanone
Show/Hide
|
C23H20N8O2
|
1
|
| 1 |
Ki = 7680 nM
|
|
|
|
CP0386542
|
1-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carbonyl]-piperidine-4-carboxylic acid
Show/Hide
|
C26H37N5O5
|
1
|
| 1 |
Ki = 7820 nM
|
|
|
|
CP0408623
|
2-[[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)bicyclo[2.2.2]octane-1-carbonyl]amino]acetic acid
Show/Hide
|
C22H31N5O5
|
1
|
| 1 |
Ki = 7880 nM
|
|
|
|
CP0968314
|
7-hydroxy-2-methyl-3-(4-methylthiazol-2-yl)-4H-chromen-4-one
Show/Hide
|
C14H11NO3S
|
1
|
| 1 |
Ki = 7943.28 nM
|
|
|
|
CP0460953
|
9-[(3-chloro-4-methoxyphenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H20ClN5O3
|
1
|
| 1 |
Ki = 8000 nM
|
|
|
|
CP0377678
|
(4-(furan-2-yl)-2-(methyl(2-(thiophen-2-yl)ethyl)amino)thiazol-5-yl)(phenyl)methanone
Show/Hide
|
C21H18N2O2S2
|
1
|
| 1 |
Ki = 8170 nM
|
|
|
|
CP0446838
|
9-[(3-bromo-4-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17BrFN5O2
|
1
|
| 1 |
Ki = 8270 nM
|
|
|
|
CP0270742
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(methylamino)-2-(phenylethynyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
Show/Hide
|
C19H19N5O4
|
1
|
| 1 |
Ki = 8530 nM
|
|
|
|
CP0401683
|
(E)-N-(amino(4-methylquinazolin-2-ylamino)methylene)-2-(methylamino)benzamide
Show/Hide
|
C18H18N6O
|
1
|
| 1 |
Ki = 8800 nM
|
|
|
|
CP0393289
|
2-(4-chlorophenoxy)-2-methyl-N-(5-phenyl-1H-1,2,4-triazol-3-yl)propanamide
Show/Hide
|
C18H17ClN4O2
|
1
|
| 1 |
Ki = 8800 nM
|
|
|
|
CP0460949
|
9-[(4-chloro-2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17ClFN5O2
|
1
|
| 1 |
Ki = 8910 nM
|
|
|
|
CP0511563
|
2-(cyclopropylamino)-7-(2-methoxybenzyl)-9-(3-methoxybenzyl)-7H-purin-8(9H)-one
Show/Hide
|
C24H25N5O3
|
1
|
| 1 |
Ki = 9213 nM
|
|
|
|
CP0258379
|
9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]triazolo[5,1-a][2,7]naphthyridine-6-carboxylic acid methyl ester
Show/Hide
|
C18H16N4O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0356282
|
5-Amino-3-(4-methoxy-phenyl)-thiazolo[3,2-a]pyrimidin-7-one
Show/Hide
|
C13H11N3O2S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0495993
|
2-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl)(methyl)amino)acetic acid
Show/Hide
|
C24H35N5O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0399843
|
3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thiazol-4-yl]-benzonitrile
Show/Hide
|
C18H13N7S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0064086
|
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-N,N-dimethyl-tetrahydrothiophene-2-carboxamide
Show/Hide
|
C19H20ClIN6O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0471995
|
2-(4-fluorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C20H15FN4O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0516509
|
2-(3-cyanophenoxy)-N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
|
C23H20N6O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0498520
|
(S)-1-[6-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]pyrrolidine-2-carboxylic Acid Methyl Ester
Show/Hide
|
C17H22N6O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0170985
|
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-N,N-dimethyl-tetrahydrofuran-2-carboxamide
Show/Hide
|
C19H20ClIN6O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0156790
|
(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-iodo-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C20H20ClIN6O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0161398
|
(1S,2R,3S,4R,5S)-4-(6-(2,5-dimethoxybenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C22H25ClN6O5
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0408228
|
(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-(methylthio)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C21H23ClN6O3S
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0852032
|
N-(3,4-dichloro-phenyl)-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C21H18Cl2N4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0881120
|
N-(4-chloro-phenyl)-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C21H19ClN4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0899579
|
N-(4-methoxy-phenyl)-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C22H22N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0497763
|
N-[(3-methoxyphenyl)methyl]-1-(3-methoxypropyl)-2-[[3-(trifluoromethyl)benzoyl]amino]benzimidazole-5-carboxamide
Show/Hide
|
C28H27F3N4O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0531866
|
3-cyano-N-(3-(3-isopropoxypropyl)-6-(morpholine-4-carbonyl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
Show/Hide
|
C25H28N6O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0374987
|
2-(3-(methylsulfonyl)-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-phenylacetamide
Show/Hide
|
C26H24N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0374988
|
N-[(3,4-dichlorophenyl)methyl]-N-methyl-2-[[3-methylsulfonyl-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C28H26Cl2N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0374989
|
2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(3,4-dichlorobenzyl)acetamide
Show/Hide
|
C27H21Cl2N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0374990
|
2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylcyclopropyl)acetamide
Show/Hide
|
C31H27N3O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0374991
|
2-(2-oxo-4-(phenoxymethyl)-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C30H27N3O4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0380531
|
N-[[2-oxo-4-(2-phenylethyl)-3-(1,3-thiazol-2-yl)-1H-quinolin-6-yl]methyl]-3-phenylpropanamide
Show/Hide
|
C30H27N3O2S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0380532
|
2-(2-oxo-4-phenethyl-3-(pyridin-4-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C33H31N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0380536
|
N-[(3,4-dichlorophenyl)methyl]-2-[[3-methylsulfonyl-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C27H24Cl2N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386032
|
N-benzyl-2-[[3-(furan-2-yl)-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C30H26N2O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386033
|
1-benzyl-3-((2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yl)methyl)urea
Show/Hide
|
C29H26N4O2S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386035
|
N-(3-methoxypropyl)-2-[[3-methylsulfonyl-2-oxo-4-(2-phenylethyl)-1H-quinolin-6-yl]oxy]acetamide
Show/Hide
|
C24H28N2O6S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386037
|
N-[(3,4-dichlorophenyl)methyl]-2-[(4-methyl-3-methylsulfonyl-2-oxo-1H-quinolin-6-yl)oxy]acetamide
Show/Hide
|
C20H18Cl2N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386038
|
N-[(3,4-dichlorophenyl)methyl]-2-[(3-methylsulfonyl-2-oxo-4-phenyl-1H-quinolin-6-yl)oxy]acetamide
Show/Hide
|
C25H20Cl2N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386039
|
(R)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(1-phenylethyl)acetamide
Show/Hide
|
C30H27N3O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0386040
|
2-(2-oxo-4-phenethyl-3-(pyridin-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C33H31N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0398044
|
2-(3-(2,4-difluorophenyl)-1-methyl-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(3-methoxypropyl)acetamide
Show/Hide
|
C30H30F2N2O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0447642
|
2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C31H29N3O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0496617
|
2-(2-oxo-4-phenethyl-3-(pyridin-3-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C33H31N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0501647
|
6-methoxy-3-(methylsulfonyl)-4-phenethylquinolin-2(1H)-one
Show/Hide
|
C19H19NO4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0501666
|
1-((2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yl)methyl)-3-(2-phenylpropan-2-yl)urea
Show/Hide
|
C31H30N4O2S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0501667
|
N-benzyl-2-[3-(2,4-difluorophenyl)-1-methyl-2-oxo-4-(2-phenylethyl)quinolin-6-yl]oxyacetamide
Show/Hide
|
C33H28F2N2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0501818
|
2-(3-(2,4-difluorophenyl)-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(3-methoxypropyl)acetamide
Show/Hide
|
C29H28F2N2O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0503027
|
2-(4-(4-fluorophenethyl)-2-oxo-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yloxy)-N-(2-phenylpropan-2-yl)acetamide
Show/Hide
|
C31H28FN3O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0506091
|
N-benzyl-2-[1-methyl-3-methylsulfonyl-2-oxo-4-(2-phenylethyl)quinolin-6-yl]oxyacetamide
Show/Hide
|
C28H28N2O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0383612
|
Adenosine analog, 8
Show/Hide
|
C13H19N7O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0066689
|
6-[2-(4-chlorophenyl)ethynyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H14ClN3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0066694
|
6-[(E)-2-(4-chlorophenyl)ethenyl]-5-ethyl-1,3-dimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H18ClN3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0067388
|
6-[(4-chlorophenyl)methoxy]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C16H16ClN3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0067389
|
4-chloro-N-(1,3,5-trimethyl-2,4-dioxopyrrolo[3,2-d]pyrimidin-6-yl)benzamide
Show/Hide
|
C16H15ClN4O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0085565
|
1,3,5-trimethyl-6-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H16F3N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0121160
|
1,3,5-trimethyl-6-(naphthalen-2-ylmethoxy)pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C20H19N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0121161
|
1,3,5-trimethyl-6-[(E)-2-pyridin-4-ylethenyl]pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C16H16N4O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0121164
|
3-[(E)-2-(1,3,5-trimethyl-2,4-dioxopyrrolo[3,2-d]pyrimidin-6-yl)ethenyl]benzonitrile
Show/Hide
|
C18H16N4O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0132439
|
6-[(E)-2-(3-acetylphenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C19H19N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0132441
|
1,3,5-trimethyl-7-phenylpyrimido[5,4-b]indole-2,4-dione
Show/Hide
|
C19H17N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0142273
|
6-[(E)-2-(4-hydroxyphenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H17N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0146927
|
6-[2-(3-chlorophenyl)ethynyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H14ClN3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0156106
|
1,3,5-trimethyl-6-(3-phenylprop-1-ynyl)pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H17N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0193334
|
6-(3-chlorophenoxy)-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C15H14ClN3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0220103
|
6-[4-(4-chlorophenyl)triazol-1-yl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H15ClN6O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0239575
|
6-[(4-chlorophenyl)methoxy]-1,3-diethyl-5-methylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H20ClN3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0248027
|
1,4-dimethyl-2-[(E)-2-phenylethenyl]imidazo[4,5-b]pyridin-5-one
Show/Hide
|
C16H15N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0248569
|
6-[(E)-2-(4-chlorophenyl)ethenyl]-1,3-diethyl-5-methylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C19H20ClN3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0248570
|
3,5-dimethyl-2-[(E)-2-phenylethenyl]imidazo[4,5-c]pyridin-4-one
Show/Hide
|
C16H15N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0262813
|
6-[[4-chloro-3-(trifluoromethyl)phenyl]methoxy]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H15ClF3N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0282253
|
6-[(E)-2-(4-bromophenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H16BrN3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0301726
|
1,3,5-trimethyl-6-(3-phenylphenoxy)pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C21H19N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0334038
|
6-[(E)-2-(3,4-dichlorophenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H15Cl2N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0499260
|
6-[2-(4-chlorophenyl)ethynyl]-1,3-diethyl-5-methylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C19H18ClN3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0406164
|
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C23H24ClN9O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0448164
|
(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C26H23Cl2N9O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0461967
|
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C27H26ClN9O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0467515
|
(1S,2R,3S,4R,5S)-4-[6-(cyclobutylamino)-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
|
C17H21IN6O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0201120
|
8-cyclopentyl-2-(3,4-difluorophenoxy)-1-propyl-7H-purin-6-one
Show/Hide
|
C19H20F2N4O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0246514
|
8-cyclopentyl-2-(3-methoxyphenyl)-1-propyl-7H-purin-6-one
Show/Hide
|
C20H24N4O2
|
1
|
| 1 |
Ki >= 10000 nM
|
|
|
|
CP0389914
|
2-(furan-2-yl)-6-phenylimidazo[1,2-a]pyridin-8-amine
Show/Hide
|
C17H13N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0475876
|
2-(3,4-dimethoxyphenyl)-6-(2-phenylethyl)imidazo[1,2-a]pyridin-8-amine
Show/Hide
|
C23H23N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0475877
|
2-(furan-2-yl)imidazo[1,2-a]pyridine
Show/Hide
|
C11H8N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0475878
|
2-(furan-2-yl)imidazo[1,2-a]pyridin-8-amine
Show/Hide
|
C11H9N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0475879
|
2,6-bis(furan-2-yl)imidazo[1,2-a]pyridin-8-amine
Show/Hide
|
C15H11N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0485523
|
2-(3,4-dimethoxyphenyl)-6-(2-phenylethynyl)imidazo[1,2-a]pyridin-8-amine
Show/Hide
|
C23H19N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0519995
|
2-(furan-2-yl)-6-phenylimidazo[1,2-a]pyridine
Show/Hide
|
C17H12N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0572525
|
6-(furan-2-yl)-2-phenylimidazo[1,2-a]pyridine
Show/Hide
|
C17H12N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0852928
|
8-amino-2-(3,4-dimethoxyphenyl)-N-(3-morpholinopropyl)imidazo[1,2-a]pyridine-6-carboxamide dihydrochloride
Show/Hide
|
C23H31Cl2N5O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0853135
|
8-amino-2-(3,4-dimethoxyphenyl)-N-(3-(4-methylpiperazin-1-yl)propyl)imidazo[1,2-a]pyridine-6-carboxamide trihydrochloride
Show/Hide
|
C24H35Cl3N6O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0930509
|
8-amino-2-(3,4-dimethoxyphenyl)-N-(3-(piperidin-1-yl)propyl)imidazo[1,2-a]pyridine-6-carboxamide dihydrochloride
Show/Hide
|
C24H33Cl2N5O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0930525
|
8-amino-2-(3,4-dimethoxyphenyl)-N-(3-(piperazin-1-yl)propyl)imidazo[1,2-a]pyridine-6-carboxamide trihydrochloride
Show/Hide
|
C23H33Cl3N6O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0930533
|
8-amino-2-(3,4-dimethoxyphenyl)-N-(4-hydroxyphenethyl)imidazo[1,2-a]pyridine-6-carboxamide hydrochloride
Show/Hide
|
C24H25ClN4O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0961354
|
8-amino-2-(3,4-dimethoxyphenyl)-N-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)imidazo [1,2-a]pyridine-6-carboxamide dihydrochloride
Show/Hide
|
C31H40Cl2N6O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0961355
|
(8-amino-2-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-6-yl)(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)methanone hydrochloride
Show/Hide
|
C29H34ClN5O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0391881
|
N-[2-(2,2-difluoro-4,6,10,12-tetramethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)ethyl]-2-[4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)phenoxy]acetamide
Show/Hide
|
C31H34BF2N7O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0457568
|
2-(furan-2-yl)-1,3-benzoxazol-5-amine
Show/Hide
|
C11H8N2O2
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0444811
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-[[5-(4-bromophenyl)furan-2-yl]methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H20BrN7O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0455811
|
(2R,3R,4S,5R)-2-[6-amino-2-[(2E)-2-(3-methylsulfanylpropylidene)hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C14H21N7O4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0362924
|
(2R,3R,4S,5R)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C17H23N5O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0381928
|
CVT-3619
Show/Hide
|
C21H24FN5O4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0383270
|
(1R,2R,3S,4R,5S)-4-(6-Amino-purin-9-yl)-1-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C12H15N5O3
|
1
|
| 1 |
Ki = 22500 nM
|
|
|
|
CP0265869
|
(2R,3R,4S,5S)-3,4-dihydroxy-2-[6-(3-iodo-benzylamino)-purin-9-yl]-1-oxa-7-aza-spiro[4.4]nonan-6-one
Show/Hide
|
C19H19IN6O4
|
1
|
| 1 |
Ki = 29800 nM
|
|
|
|
CP0486927
|
2-amino-4-(2H-1,3-benzodioxol-5-yl)-6-methoxypyridine-3,5-dicarbonitrile
Show/Hide
|
C15H10N4O3
|
1
|
| 1 |
Ki = 31000 nM
|
|
|
|
CP0856389
|
2,2'-(2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diyl)bis(azanediyl)diethanaminium 2,2,2-trifluoroacetate
Show/Hide
|
C16H19F6N9O5
|
1
|
| 1 |
Ki = 38200 nM
|
|
|
|
CP0247766
|
3-Propyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C8H10N4O2
|
1
|
| 1 |
Ki = 81300 nM
|
|
|
|
CP0845658
|
1-(6-Amino-purin-9-yl)-4-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C12H15N5O3
|
1
|
| 1 |
Ki = 100000 nM
|
|
|
|
CP0474765
|
1,3-Dimethyl-8-[3-methoxy-4-(2-morpholin-4-ylethoxy)-phenylxanthine
Show/Hide
|
C20H25N5O5
|
1
|
| 1 |
Ki = 100000 nM
|
|
|
|
CP0373438
|
2-(3,4-Dimethoxy-phenyl)-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-acetamide
Show/Hide
|
C25H31N7O5
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0085633
|
1,3,5-trimethyl-8-phenylmethoxypyrimido[5,4-b]indole-2,4-dione
Show/Hide
|
C20H19N3O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0115073
|
4-[(E)-2-(1,3,5-trimethyl-2,4-dioxopyrrolo[3,2-d]pyrimidin-6-yl)ethenyl]benzonitrile
Show/Hide
|
C18H16N4O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0132438
|
1,3,5-trimethyl-6-[(E)-2-(4-methylsulfonylphenyl)ethenyl]pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C18H19N3O4S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0146929
|
7-(3-chlorophenyl)-1,3,5-trimethylpyrimido[5,4-b]indole-2,4-dione
Show/Hide
|
C19H16ClN3O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0248023
|
6-[(E)-2-(3-hydroxyphenyl)ethenyl]-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C17H17N3O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0248055
|
6-(6-chloro-1,3-benzoxazol-2-yl)-1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C16H13ClN4O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0485398
|
(E)-N-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)-N-methyl-3-phenylprop-2-enamide
Show/Hide
|
C16H17N3O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0415983
|
3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C18H22F3N3O4S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0360696
|
10-[(3-bromophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20BrN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0360697
|
10-[(4-chlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20ClN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0410874
|
10-[(3-bromo-4-fluorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H19BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0420993
|
1,3-dimethyl-9-[(3,4,5-trifluorophenyl)methyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H16F3N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0420996
|
6-[(3,4-dichlorophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H15Cl2N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446834
|
6-[(4-chlorophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H16ClN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446835
|
1,3-dimethyl-9-[(3-methylphenyl)methyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H21N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446970
|
9-[(5-bromo-2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446972
|
9-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H17ClF3N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446973
|
9-[(2-chloro-4-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17ClFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446988
|
6-[(3-bromo-4-fluorophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H15BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446989
|
9-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H17ClF3N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0460952
|
1,3-dimethyl-9-(2-pyridin-4-ylethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H20N6O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0463490
|
9-[(4-bromo-2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0468800
|
10-[(3,4-dichlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H19Cl2N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0477295
|
9-[(2,5-dichlorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17Cl2N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0482946
|
9-[(4-chloro-3-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17ClFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0490278
|
9-[(4-tert-butylphenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C21H27N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0570386
|
5-bromo-N-[4-(3,5-dimethylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
|
C22H17BrN4OS
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0442192
|
2-Hydroxymethyl-5-[6-(3-iodo-benzylamino)-2-(4-pyridin-2-yl-pyrazol-1-yl)-purin-9-yl]-tetrahydro-furan-3,4-diol
Show/Hide
|
C25H23IN8O4
|
1
|
| 1 |
Ki > 3900 nM
|
|
|
|
CP0485548
|
1-[9-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-methylamino-9H-purin-2-yl]-1H-pyrazole-4-carboxylic acid propylamide
Show/Hide
|
C18H24N8O5
|
1
|
| 1 |
Ki > 4000 nM
|
|
|
|
CP0435271
|
1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid
Show/Hide
|
C18H21N7O7
|
1
|
| 1 |
Ki > 4000 nM
|
|
|
|
CP0435425
|
2-Hydroxymethyl-5-[6-methylamino-2-(4-pyridin-4-yl-pyrazol-1-yl)-purin-9-yl]-tetrahydro-furan-3,4-diol
Show/Hide
|
C19H20N8O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0440382
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(methylamino)-2-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C19H20N8O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0442189
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(4-methoxyphenyl)-1H-pyrazol-1-yl)-6-(methylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C21H23N7O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0442194
|
2-Hydroxymethyl-5-[6-methylamino-2-(4-quinolin-2-yl-pyrazol-1-yl)-purin-9-yl]-tetrahydro-furan-3,4-diol
Show/Hide
|
C23H22N8O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0469564
|
2-[2-(1-Benzyl-1H-pyrazol-4-yl)-6-methylamino-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C21H23N7O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0485968
|
2-{2-[4-(4-Chloro-phenyl)-pyrazol-1-yl]-6-methylamino-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C20H20ClN7O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0311323
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H17F3N6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0372911
|
8-(1-benzyl-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C18H18N6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0372913
|
1-butyl-8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H19ClN8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0372914
|
1-propyl-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H17F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0372915
|
1-ethyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C18H15F3N6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0372917
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C17H15FN6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0405103
|
8-(1-benzyl-1H-pyrazol-4-yl)-1-isobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0405149
|
1-(cyclopropylmethyl)-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H17F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0405151
|
1-isobutyl-8-(1-((5-phenylisoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H21N7O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0405152
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H17F3N6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0405154
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-butyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H19FN6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0444318
|
8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H17ClN8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0444319
|
1-isobutyl-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H19F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457683
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-butyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457685
|
1-(cyclopropylmethyl)-8-(1-((5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H18F3N7O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457867
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-isobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457869
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-isobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H19FN6O2
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457871
|
8-(1-((5-(4-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H18ClN7O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457872
|
8-(1-((5-phenylisoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H19N7O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457873
|
8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H17ClN8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0457889
|
8-(1-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H18N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0373144
|
8-[1-[[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]methyl]pyrazol-4-yl]-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C22H21ClN8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0422081
|
3-ethyl-1-propyl-8-[1-[[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C23H21F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0374794
|
ethyl 1-[6-(cyclopentylamino)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
|
C21H27N7O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0374795
|
1-(6-(p-toluidino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H26N8O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0374796
|
2-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-9H-purin-6-ylamino)isonicotinic acid
Show/Hide
|
C20H20N8O7
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0374797
|
1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C19H24N8O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0426958
|
N-[(4-chlorophenyl)methyl]-1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carboxamide
Show/Hide
|
C25H27ClN8O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0426959
|
N-benzyl-1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carboxamide
Show/Hide
|
C25H28N8O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0427018
|
(2R,3R,4S,5R)-2-(6-(cyclopentylamino)-2-(1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C18H23N7O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0427023
|
1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(quinolin-2-ylamino)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C25H25N9O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0427026
|
1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid
Show/Hide
|
C19H23N7O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0430041
|
1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]-N-[(4-fluorophenyl)methyl]pyrazole-4-carboxamide
Show/Hide
|
C25H27FN8O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0435267
|
ethyl 1-[6-(cyclohexylamino)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
|
C22H29N7O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0435268
|
(2R,3R,4S,5R)-2-(6-(bicyclo[2.2.1]heptan-1-ylamino)-2-(1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C20H25N7O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0435272
|
1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C21H28N8O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0435273
|
1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-N-propyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C21H28N8O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0435639
|
ethyl 1-[6-(1-bicyclo[2.2.1]heptanylamino)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
|
C23H29N7O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0435640
|
1-(6-(cyclohexylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C21H28N8O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0440380
|
1-(6-(bicyclo[2.2.1]heptan-1-ylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid
Show/Hide
|
C21H25N7O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0445456
|
4-((1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-1H-pyrazole-4-carboxamido)methyl)benzoic acid
Show/Hide
|
C26H28N8O8
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0449772
|
1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C20H26N8O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0449773
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(4-(trifluoromethyl)phenylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C21H20F3N7O5
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0461923
|
ethyl 4-[[[1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carbonyl]amino]methyl]benzoate
Show/Hide
|
C28H32N8O8
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0372447
|
1,3-dipropyl-8-(1-((3-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0372450
|
1,3-dipropyl-8-(1-((3-m-tolyl-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0376115
|
1,3-dipropyl-8-(1-((3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0376621
|
8-(1-((5-(2-methoxyphenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0382443
|
8-(1-((5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0382444
|
1,3-dipropyl-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0382445
|
8-(1-((3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0382447
|
4-(5-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1H-pyrazol-1-yl)methyl)-1,2,4-oxadiazol-3-yl)benzonitrile
Show/Hide
|
C24H23N9O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0392196
|
4-(3-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1H-pyrazol-1-yl)methyl)-1,2,4-oxadiazol-5-yl)benzonitrile
Show/Hide
|
C24H23N9O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0394605
|
8-(1-((5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0422167
|
1,3-dipropyl-8-(1-((5-(2-(trifluoromethyl)phenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H24F3N7O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0422188
|
8-(1-((5-(3-methoxyphenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0428285
|
8-(1-((3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0428286
|
8-(1-((5-(3-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H24ClN7O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0436633
|
8-(1-((3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0436635
|
1,3-dipropyl-8-(1-((5-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0436645
|
8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0446658
|
1,3-dipropyl-8-(1-((3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0467758
|
8-(1-((5-(4-methoxyphenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0494603
|
8-(1-((5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0505667
|
1,3-dipropyl-8-(1-((5-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0441716
|
1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(methylamino)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C16H20N8O5
|
1
|
| 1 |
Ki > 6000 nM
|
|
|
