General Information of the Compound
Compound ID
CP0404771
Compound Name
6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine
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Synonyms
6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine
CHEMBL194383
SCHEMBL3272682
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Structure
Formula
C17H15N5O
Molecular Weight
305.341
Canonical SMILES
Nc1nc(-c2ccco2)c2ncn(CCc3ccccc3)c2n1
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InChI
InChI=1S/C17H15N5O/c18-17-20-14(13-7-4-10-23-13)15-16(21-17)22(11-19-15)9-8-12-5-2-1-3-6-12/h1-7,10-11H,8-9H2,(H2,18,20,21)
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InChIKey
LOCNLYLIABVQFH-UHFFFAOYSA-N
Physicochemical Property
logP
2.9112
Rotatable Bonds
4
Heavy Atom Count
23
Polar Areas
82.76
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44401799
ChEMBL ID
CHEMBL194383
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 270.5 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine )
Drug Name 6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine
Target(s)
Adenosine A2a receptor (ADORA2A)
Inhibitor