General Information of the Compound
Compound ID
CP0575044
Compound Name
2-amino-8-[2-[4-[4-(difluoromethoxy)-2-fluorophenyl]piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C24H24F3N7O3
Molecular Weight
515.496
Canonical SMILES
Cc1ccc(o1)-c1nc(N)nc2n(CCN3CCN(CC3)c3ccc(OC(F)F)cc3F)c(=O)cnc12
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InChI
InChI=1S/C24H24F3N7O3/c1-14-2-5-18(36-14)20-21-22(31-24(28)30-20)34(19(35)13-29-21)11-8-32-6-9-33(10-7-32)17-4-3-15(12-16(17)25)37-23(26)27/h2-5,12-13,23H,6-11H2,1H3,(H2,28,30,31)
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InChIKey
QGECMPYZQFGGQK-UHFFFAOYSA-N
Physicochemical Property
logP
2.89982
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
115.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166633292
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 21 nM
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