General Information of the Compound
Compound ID
CP0408007
Compound Name
5-amino-8-(furan-2-yl)-3-[2-[4-[4-(1-methoxypropan-2-yloxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
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Structure
Formula
C27H33N9O4
Molecular Weight
547.62
Canonical SMILES
COCC(C)Oc1ccc(cc1)N1CCN(CCn2c3nc(N)n4nc(nc4c3n(C)c2=O)-c2ccco2)CC1
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InChI
InChI=1S/C27H33N9O4/c1-18(17-38-3)40-20-8-6-19(7-9-20)34-13-10-33(11-14-34)12-15-35-24-22(32(2)27(35)37)25-29-23(21-5-4-16-39-21)31-36(25)26(28)30-24/h4-9,16,18H,10-15,17H2,1-3H3,(H2,28,30)
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InChIKey
HURASBAMXINLCB-UHFFFAOYSA-N
Physicochemical Property
logP
1.8558
Rotatable Bonds
9
Heavy Atom Count
40
Polar Areas
134.11
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
13
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145964038
ChEMBL ID
CHEMBL4209408
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 0.4 nM
   TI
   LI
   LO
   TS
2
Ki = 1.5 nM
   TI
   LI
   LO
   TS