General Information of the Compound
Compound ID
CP0460419
Compound Name
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(cycloheptylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
    Show/Hide
Structure
Formula
C18H24ClN5O2
Molecular Weight
377.876
Canonical SMILES
O[C@@H]1[C@@H]2C[C@@H]2[C@H]([C@@H]1O)n1cnc2c(NC3CCCCCC3)nc(Cl)nc12
    Show/Hide
InChI
InChI=1S/C18H24ClN5O2/c19-18-22-16(21-9-5-3-1-2-4-6-9)12-17(23-18)24(8-20-12)13-10-7-11(10)14(25)15(13)26/h8-11,13-15,25-26H,1-7H2,(H,21,22,23)/t10-,11+,13+,14+,15-/m0/s1
    Show/Hide
InChIKey
KYVGFSDVXJJOGC-JHOKLZQASA-N
Physicochemical Property
logP
2.527
Rotatable Bonds
3
Heavy Atom Count
26
Polar Areas
96.09
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 70681087
ChEMBL ID
CHEMBL2012676
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 230 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3930 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 560 nM
   TI
   LI
   LO
   TS