General Information of the Compound
Compound ID
CP0513474
Compound Name
(2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]butanedioic acid
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Structure
Formula
C27H34N8O9
Molecular Weight
614.616
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NCCc3ccc(CCC(=O)N[C@H](CC(O)=O)C(O)=O)cc3)nc12
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InChI
InChI=1S/C27H34N8O9/c1-2-29-24(41)21-19(39)20(40)25(44-21)35-12-31-18-22(28)33-27(34-23(18)35)30-10-9-14-5-3-13(4-6-14)7-8-16(36)32-15(26(42)43)11-17(37)38/h3-6,12,15,19-21,25,39-40H,2,7-11H2,1H3,(H,29,41)(H,32,36)(H,37,38)(H,42,43)(H3,28,30,33,34)/t15-,19+,20-,21+,25-/m1/s1
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InChIKey
NVFHZJAWBNENJM-QNLLXNTNSA-N
Physicochemical Property
logP
-1.2049
Rotatable Bonds
14
Heavy Atom Count
44
Polar Areas
264.14
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
13
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56945770
SID: 135648135
ChEMBL ID
CHEMBL1950658
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1180 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 110 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 790 nM
   TI
   LI
   LO
   TS