General Information of the Compound
Compound ID
CP0371804
Compound Name
(1S,2R,3S,4R,5S)-4'-(6-(3-Chlorobenzylamino)-2-(6-(1-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)hex-1-ynyl)-9H-purin-9-yl)-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide
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Structure
Formula
C34H33ClN10O5
Molecular Weight
697.156
Canonical SMILES
CNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n1cnc2c(NCc3cccc(Cl)c3)nc(nc12)C#CCCCCc1cn(nn1)-c1cccc(c1)[N+]([O-])=O
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InChI
InChI=1S/C34H33ClN10O5/c1-36-33(48)34-16-25(34)28(29(46)30(34)47)43-19-38-27-31(37-17-20-8-6-9-21(35)14-20)39-26(40-32(27)43)13-5-3-2-4-10-22-18-44(42-41-22)23-11-7-12-24(15-23)45(49)50/h6-9,11-12,14-15,18-19,25,28-30,46-47H,2-4,10,16-17H2,1H3,(H,36,48)(H,37,39,40)/t25-,28-,29+,30+,34+/m1/s1
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InChIKey
VUMUJRMOLVNSCZ-HDFRBTCWSA-N
Physicochemical Property
logP
3.374
Rotatable Bonds
11
Heavy Atom Count
50
Polar Areas
199.04
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
13
Complexity
50

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46230548
ChEMBL ID
CHEMBL589262
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 6730 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10.6 nM
   TI
   LI
   LO
   TS