General Information of the Compound
Compound ID
CP0415261
Compound Name
2-amino-N-[(4-butoxyquinolin-8-yl)methyl]-8-fluoroquinazoline-4-carboxamide
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Structure
Formula
C23H22FN5O2
Molecular Weight
419.46
Canonical SMILES
CCCCOc1ccnc2c(CNC(=O)c3nc(N)nc4c(F)cccc34)cccc12
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InChI
InChI=1S/C23H22FN5O2/c1-2-3-12-31-18-10-11-26-19-14(6-4-7-15(18)19)13-27-22(30)21-16-8-5-9-17(24)20(16)28-23(25)29-21/h4-11H,2-3,12-13H2,1H3,(H,27,30)(H2,25,28,29)
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InChIKey
MLMXORBEZPDELJ-UHFFFAOYSA-N
Physicochemical Property
logP
4.0082
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
103.02
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127041637
ChEMBL ID
CHEMBL3763647
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 748 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 245 nM
   TI
   LI
   LO
   TS