General Information of the Compound
Compound ID
CP0532874
Compound Name
CPI-444
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Synonyms
V81444
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Structure
Formula
C20H21N7O3
Molecular Weight
407.434
Canonical SMILES
Cc1ccc(o1)-c1nc(N)nc2n(Cc3cccc(CO[C@H]4CCOC4)n3)nnc12
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InChI
InChI=1S/C20H21N7O3/c1-12-5-6-16(30-12)17-18-19(24-20(21)23-17)27(26-25-18)9-13-3-2-4-14(22-13)10-29-15-7-8-28-11-15/h2-6,15H,7-11H2,1H3,(H2,21,23,24)/t15-/m0/s1
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InChIKey
KURQKNMKCGYWRJ-HNNXBMFYSA-N
CAS
1202402-40-1
Physicochemical Property
logP
2.12072
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
127
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44537963
SID: 87219378
ChEMBL ID
CHEMBL4297184
DrugBank ID
DB16125
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 86.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 3353 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 > 10000 nM
Clinical Information about the Compound
Drug 1 ( V81444 )
Drug Name V81444
Company Vernalis
Indication
Parkinson disease
Phase 1/2
Advanced cancer
Phase 1
Target(s)
Adenosine A2a receptor (ADORA2A)
Antagonist