General Information of the Compound
Compound ID
CP0573888
Compound Name
2-amino-8-[2-[(1S,4S)-5-(4-methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C25H27N7O3
Molecular Weight
473.537
Canonical SMILES
COc1ccc(cc1)N1C[C@@H]2C[C@H]1CN2CCn1c2nc(N)nc(-c3ccc(C)o3)c2ncc1=O
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InChI
InChI=1S/C25H27N7O3/c1-15-3-8-20(35-15)22-23-24(29-25(26)28-22)31(21(33)12-27-23)10-9-30-13-18-11-17(30)14-32(18)16-4-6-19(34-2)7-5-16/h3-8,12,17-18H,9-11,13-14H2,1-2H3,(H2,26,28,29)/t17-,18-/m0/s1
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InChIKey
CUZJYJCDTLGEOB-ROUUACIJSA-N
Physicochemical Property
logP
2.30882
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
115.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215439
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS