General Information of the Compound
Compound ID
CP0108313
Compound Name
N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]-1,3-thiazol-2-amine
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Structure
Formula
C18H23N7OS
Molecular Weight
385.497
Canonical SMILES
COC[C@H]1CCCN1c1cc(Nc2nccs2)nc(n1)-n1nc(C)cc1C
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InChI
InChI=1S/C18H23N7OS/c1-12-9-13(2)25(23-12)17-20-15(21-18-19-6-8-27-18)10-16(22-17)24-7-4-5-14(24)11-26-3/h6,8-10,14H,4-5,7,11H2,1-3H3,(H,19,20,21,22)/t14-/m1/s1
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InChIKey
XDYKDWJFSMJUFV-CQSZACIVSA-N
Physicochemical Property
logP
3.09444
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
80.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72945117
ChEMBL ID
CHEMBL3098228
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 9.5 nM
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