General Information of the Compound
Compound ID
CP0244328
Compound Name
2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-N-pyrazin-2-ylpyrimidin-4-amine
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Structure
Formula
C19H24N8O
Molecular Weight
380.456
Canonical SMILES
COC[C@H]1CCCN1c1cc(Nc2cnccn2)nc(n1)-n1nc(C)cc1C
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InChI
InChI=1S/C19H24N8O/c1-13-9-14(2)27(25-13)19-23-16(22-17-11-20-6-7-21-17)10-18(24-19)26-8-4-5-15(26)12-28-3/h6-7,9-11,15H,4-5,8,12H2,1-3H3,(H,21,22,23,24)/t15-/m1/s1
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InChIKey
SWYQWMVVQGHPSG-OAHLLOKOSA-N
Physicochemical Property
logP
2.42794
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
93.88
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24989640
SID: 56331638
ChEMBL ID
CHEMBL3098227
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 69 nM
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