General Information of the Compound
Compound ID
CP0385405
Compound Name
tert-butyl N-[2-[[2-(furan-2-yl)-5-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino]ethyl]carbamate
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Structure
Formula
C22H33N9O5
Molecular Weight
503.564
Canonical SMILES
CC(C)(C)OC(=O)NCCNc1nc(NCCNC(=O)OC(C)(C)C)n2nc(nc2n1)-c1ccco1
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InChI
InChI=1S/C22H33N9O5/c1-21(2,3)35-19(32)25-11-9-23-16-28-17(24-10-12-26-20(33)36-22(4,5)6)31-18(29-16)27-15(30-31)14-8-7-13-34-14/h7-8,13H,9-12H2,1-6H3,(H,25,32)(H,26,33)(H2,23,24,27,28,29,30)
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InChIKey
WBPQESSCKHAZEZ-UHFFFAOYSA-N
Physicochemical Property
logP
2.6525
Rotatable Bonds
9
Heavy Atom Count
36
Polar Areas
169.83
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
12
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 51051245
SID: 118045621
ChEMBL ID
CHEMBL1927425
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 4360 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8490 nM
   TI
   LI
   LO
   TS