General Information of the Compound
Compound ID
CP0386013
Compound Name
N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutanamide
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Synonyms
820961-46-4
AKOS030569389
BDBM50157671
Butanamide, N-(2,6-diphenyl-4-pyrimidinyl)-2-ethyl-
CHEMBL390535
CTK3E2657
DTXSID00463914
N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide
SCHEMBL4827158
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Structure
Formula
C22H23N3O
Molecular Weight
345.446
Canonical SMILES
CCC(CC)C(=O)Nc1cc(nc(n1)-c1ccccc1)-c1ccccc1
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InChI
InChI=1S/C22H23N3O/c1-3-16(4-2)22(26)25-20-15-19(17-11-7-5-8-12-17)23-21(24-20)18-13-9-6-10-14-18/h5-16H,3-4H2,1-2H3,(H,23,24,25,26)
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InChIKey
ZMYSFVQFZFGCMP-UHFFFAOYSA-N
Physicochemical Property
logP
5.1853
Rotatable Bonds
6
Heavy Atom Count
26
Polar Areas
54.88
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11371386
SID: 16464557
ChEMBL ID
CHEMBL390535
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6.35 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 381 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide )
Drug Name N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide
Target(s)
Adenosine A2a receptor (ADORA2A)
Inhibitor
Adenosine A1 receptor (ADORA1)
Inhibitor