General Information of the Compound
Compound ID
CP0571547
Compound Name
2-amino-8-[2-[3-(4-methoxyphenyl)-3,8-diazabicyclo[3.2.1]octan-8-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C26H29N7O3
Molecular Weight
487.564
Canonical SMILES
COc1ccc(cc1)N1CC2CCC(C1)N2CCn1c2nc(N)nc(-c3ccc(C)o3)c2ncc1=O
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InChI
InChI=1S/C26H29N7O3/c1-16-3-10-21(36-16)23-24-25(30-26(27)29-23)33(22(34)13-28-24)12-11-32-18-4-5-19(32)15-31(14-18)17-6-8-20(35-2)9-7-17/h3,6-10,13,18-19H,4-5,11-12,14-15H2,1-2H3,(H2,27,29,30)
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InChIKey
GMFOJJKMBOYICL-UHFFFAOYSA-N
Physicochemical Property
logP
2.69892
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
115.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215461
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 554.7 nM
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