General Information of the Compound
Compound ID
CP0853135
Compound Name
8-amino-2-(3,4-dimethoxyphenyl)-N-(3-(4-methylpiperazin-1-yl)propyl)imidazo[1,2-a]pyridine-6-carboxamide trihydrochloride
    Show/Hide
Structure
Formula
C24H35Cl3N6O3
Molecular Weight
561.942
Canonical SMILES
COc1ccc(-c2cn3cc(C(=O)NCCCN4CCN(C)CC4)cc(N)c3n2)cc1OC.Cl.Cl.Cl
    Show/Hide
InChI
InChI=1S/C24H32N6O3.3ClH/c1-28-9-11-29(12-10-28)8-4-7-26-24(31)18-13-19(25)23-27-20(16-30(23)15-18)17-5-6-21(32-2)22(14-17)33-3;;;/h5-6,13-16H,4,7-12,25H2,1-3H3,(H,26,31);3*1H
    Show/Hide
InChIKey
PDCVAHADFVYUPQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.2334
Rotatable Bonds
8
Heavy Atom Count
36
Polar Areas
97.36
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 145954236
ChEMBL ID
CHEMBL4127251
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000004 SH-SY5Y Homo sapiens (Human)  1
1
CC50 > 100000 nM
   TI
   LI
   LO
   TS