General Information of the Compound
Compound ID
CP0174914
Compound Name
3-[6-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-1-methylindazol-3-yl]imidazo[1,2-a]pyridine-6-carbonitrile
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Structure
Formula
C23H22N6O2
Molecular Weight
414.469
Canonical SMILES
COC[C@H]1CCCN1C(=O)c1ccc2c(nn(C)c2c1)-c1cnc2ccc(cn12)C#N
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InChI
InChI=1S/C23H22N6O2/c1-27-19-10-16(23(30)28-9-3-4-17(28)14-31-2)6-7-18(19)22(26-27)20-12-25-21-8-5-15(11-24)13-29(20)21/h5-8,10,12-13,17H,3-4,9,14H2,1-2H3/t17-/m1/s1
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InChIKey
DXNSJZNPTGVXTF-QGZVFWFLSA-N
Physicochemical Property
logP
3.01068
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
88.45
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46846866
ChEMBL ID
CHEMBL3260730
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 3 nM