General Information of the Compound
Compound ID
CP0396606
Compound Name
7-N-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-7-N-methyl-2-(1,3-oxazol-5-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
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Structure
Formula
C21H23F2N9O
Molecular Weight
455.473
Canonical SMILES
CN(CCN1CCN(CC1)c1ccc(F)cc1F)c1cc2nc(nn2c(N)n1)-c1cnco1
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InChI
InChI=1S/C21H23F2N9O/c1-29(4-5-30-6-8-31(9-7-30)16-3-2-14(22)10-15(16)23)18-11-19-26-20(17-12-25-13-33-17)28-32(19)21(24)27-18/h2-3,10-13H,4-9H2,1H3,(H2,24,27)
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InChIKey
IOXYCIDLLJVUPF-UHFFFAOYSA-N
Physicochemical Property
logP
1.8981
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
104.85
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44571767
ChEMBL ID
CHEMBL480542
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 0.3 nM
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   LI
   LO
   TS