General Information of the Compound
Compound ID
CP0577558
Compound Name
2-amino-8-[2-[4-(3-fluoro-5-methoxypyridin-2-yl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C23H25FN8O3
Molecular Weight
480.504
Canonical SMILES
COc1cnc(N2CCN(CCn3c4nc(N)nc(-c5ccc(C)o5)c4ncc3=O)CC2)c(F)c1
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InChI
InChI=1S/C23H25FN8O3/c1-14-3-4-17(35-14)19-20-22(29-23(25)28-19)32(18(33)13-26-20)10-7-30-5-8-31(9-6-30)21-16(24)11-15(34-2)12-27-21/h3-4,11-13H,5-10H2,1-2H3,(H2,25,28,29)
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InChIKey
VWRASBCGIZFJEJ-UHFFFAOYSA-N
Physicochemical Property
logP
1.70202
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
128.43
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215498
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 5.5 nM
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