General Information of the Compound
Compound ID
CP0431163
Compound Name
(2R)-2-[3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoylamino]-3-(1H-indol-3-yl)propanoic acid
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Structure
Formula
C34H39N9O7
Molecular Weight
685.742
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NCCc3ccc(CCC(=O)N[C@H](Cc4c[nH]c5ccccc45)C(O)=O)cc3)nc12
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InChI
InChI=1S/C34H39N9O7/c1-2-36-31(47)28-26(45)27(46)32(50-28)43-17-39-25-29(35)41-34(42-30(25)43)37-14-13-19-9-7-18(8-10-19)11-12-24(44)40-23(33(48)49)15-20-16-38-22-6-4-3-5-21(20)22/h3-10,16-17,23,26-28,32,38,45-46H,2,11-15H2,1H3,(H,36,47)(H,40,44)(H,48,49)(H3,35,37,41,42)/t23-,26+,27-,28+,32-/m1/s1
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InChIKey
SLFPVNKYLXEKBK-OVSGKPRASA-N
Physicochemical Property
logP
1.0444
Rotatable Bonds
14
Heavy Atom Count
50
Polar Areas
242.63
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
12
Complexity
50

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56945994
SID: 135648374
ChEMBL ID
CHEMBL1950664
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2160 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 130 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 520 nM
   TI
   LI
   LO
   TS