General Information of the Compound
Compound ID
CP0571545
Compound Name
2-amino-8-[2-[4-(2-fluoro-4-methoxyphenyl)piperazin-1-yl]ethyl]-4-(5-methylfuran-2-yl)pteridin-7-one
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Structure
Formula
C24H26FN7O3
Molecular Weight
479.516
Canonical SMILES
COc1ccc(N2CCN(CCn3c4nc(N)nc(-c5ccc(C)o5)c4ncc3=O)CC2)c(F)c1
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InChI
InChI=1S/C24H26FN7O3/c1-15-3-6-19(35-15)21-22-23(29-24(26)28-21)32(20(33)14-27-22)12-9-30-7-10-31(11-8-30)18-5-4-16(34-2)13-17(18)25/h3-6,13-14H,7-12H2,1-2H3,(H2,26,28,29)
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InChIKey
ZXXGDJMDSIMSTR-UHFFFAOYSA-N
Physicochemical Property
logP
2.30702
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
115.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166630804
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4.9 nM
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