General Information of the Compound
Compound ID
CP0538799
Compound Name
2-amino-4-(5-methylfuran-2-yl)-8-[2-[4-[4-(trifluoromethoxy)phenyl]piperazin-1-yl]ethyl]pteridin-7-one
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Structure
Formula
C24H24F3N7O3
Molecular Weight
515.496
Canonical SMILES
Cc1ccc(o1)-c1nc(N)nc2n(CCN3CCN(CC3)c3ccc(OC(F)(F)F)cc3)c(=O)cnc12
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InChI
InChI=1S/C24H24F3N7O3/c1-15-2-7-18(36-15)20-21-22(31-23(28)30-20)34(19(35)14-29-21)13-10-32-8-11-33(12-9-32)16-3-5-17(6-4-16)37-24(25,26)27/h2-7,14H,8-13H2,1H3,(H2,28,30,31)
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InChIKey
QQPOSZVIQBIWSZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.05792
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
115.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163215496
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 120.2 nM
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