General Information of the Compound
Compound ID
CP0493379
Compound Name
3-cyano-N-(6-(piperidine-1-carbonyl)-3-(tetrahydro-2H-pyran-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzamide
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Structure
Formula
C25H26N6O3
Molecular Weight
458.522
Canonical SMILES
O=C(Nc1nc2cc(cnc2n1C1CCOCC1)C(=O)N1CCCCC1)c1cccc(c1)C#N
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InChI
InChI=1S/C25H26N6O3/c26-15-17-5-4-6-18(13-17)23(32)29-25-28-21-14-19(24(33)30-9-2-1-3-10-30)16-27-22(21)31(25)20-7-11-34-12-8-20/h4-6,13-14,16,20H,1-3,7-12H2,(H,28,29,32)
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InChIKey
ZWVWCKOJGDHDIG-UHFFFAOYSA-N
Physicochemical Property
logP
3.53288
Rotatable Bonds
4
Heavy Atom Count
34
Polar Areas
113.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52945246
ChEMBL ID
CHEMBL1271016
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 179 nM
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   LI
   LO
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