General Information of the Compound
Compound ID
CP0564551
Compound Name
US10988455, Example 1(xcv)
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Synonyms
1321514-06-0
5-(4-fluorophenyl)-6-(2-chloro-6-methyl-pyridin-4-yl)-1,2,4-triazin-3-amine
6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
AC-30333
AZD-4635
AZD4635
CS-0022379
EX-A1681
HY-101980
NCWQLHHDGDXIJN-UHFFFAOYSA-N
SCHEMBL2320714
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Structure
Formula
C15H11ClFN5
Molecular Weight
315.739
Canonical SMILES
Cc1cc(cc(Cl)n1)-c1nnc(N)nc1-c1ccc(F)cc1
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InChI
InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
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InChIKey
NCWQLHHDGDXIJN-UHFFFAOYSA-N
CAS
1321514-06-0
Physicochemical Property
logP
3.28372
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
77.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 86676119
ChEMBL ID
CHEMBL4594442
DrugBank ID
DB16192
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 298.8 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( AZD4635 )
Drug Name AZD4635
Company AstraZeneca Wilmington, DE
Indication
Prostate cancer
Phase 2
Solid tumour/cancer
Phase 1
Target(s)
Adenosine A2a receptor (ADORA2A)
Antagonist