General Information of the Compound
Compound ID
CP0519763
Compound Name
2-amino-N-[[6-[(2-fluorophenoxy)methyl]pyridin-2-yl]methyl]-8-methoxyquinazoline-4-carboxamide
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Structure
Formula
C23H20FN5O3
Molecular Weight
433.443
Canonical SMILES
COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(COc2ccccc2F)n1
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InChI
InChI=1S/C23H20FN5O3/c1-31-19-11-5-8-16-20(19)28-23(25)29-21(16)22(30)26-12-14-6-4-7-15(27-14)13-32-18-10-3-2-9-17(18)24/h2-11H,12-13H2,1H3,(H,26,30)(H2,25,28,29)
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InChIKey
UJNRKSMTNRVTLT-UHFFFAOYSA-N
Physicochemical Property
logP
3.2637
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
112.25
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122444984
ChEMBL ID
CHEMBL3973920
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 0.2 nM
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