General Information of the Compound
Compound ID
CP0501802
Compound Name
(R)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-((1-methylpyrrolidin-3-yloxy)methyl)phenyl)pyrimidin-4-yl)acetamide
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Structure
Formula
C23H28N6O2
Molecular Weight
420.517
Canonical SMILES
CN1CC[C@H](C1)OCc1cccc(c1)-c1cc(NC(C)=O)nc(n1)-n1nc(C)cc1C
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InChI
InChI=1S/C23H28N6O2/c1-15-10-16(2)29(27-15)23-25-21(12-22(26-23)24-17(3)30)19-7-5-6-18(11-19)14-31-20-8-9-28(4)13-20/h5-7,10-12,20H,8-9,13-14H2,1-4H3,(H,24,25,26,30)/t20-/m1/s1
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InChIKey
HQGPRKKHKJMXJP-HXUWFJFHSA-N
Physicochemical Property
logP
3.12524
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
85.17
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44589996
ChEMBL ID
CHEMBL511118
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 67 nM
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